An embolic protection device comprises a tubular filter body attached to a sheath. The tubular filter body has an open upstream end and a generally closed downstream end for capturing emboli. A self-opening passage through the emboli capture end of the tubular filter body allows multiple catheters to be advanced from the sheath or otherwise into the filter body simultaneously or sequentially. The sheath is attached to a peripheral support structure near the emboli capture end of the filter body to facilitate deployment and retrieval of the filter body through a restraining delivery catheter.

A treatment system includes a dual lumen catheter system. The first lumen is open to systemic circulation. The second lumen is open to a target delivery location. In an embodiment, a pressure-control element is provided that includes an expanded configuration adapted to constrain delivery through the second lumen to the target delivery location. Methods for treating tissues and organs via vascular pathways are provided.

An attachment configuration for a vascular filter assembly including a self-expanding filter member attached to a catheter body and constrained from expansion in a first configuration by a constraining sheath is presented. The attachment configuration includes an outer tube of material that is overlaid over an end of the filter member and bonded to the catheter body through cutouts disposed through the end of the filter member.

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

A catheter device for transvascular delivery of a medical device to a cardiac valve region of a patient comprises an elongate sheath with a first lumen, a distal end for positioning at a heart valve, a second lumen that extends parallel to or in the sheath, and an expandable embolic protection filter. The filter is arranged to extend from an orifice of the second lumen and, in the expanded, covers ostia of the side branch vessels in the aortic arch.

A method of inducing retrograde blood flow may include extending a sheath through opposite walls of one of an artery and a vein of a subject and through a wall of the other of the artery and the vein such that a distal end of the sheath may be positioned within one of the artery and the vein. The method may include inducing retrograde blood flow in the artery and delivering the induced retrograde blood flow into the vein of the subject via the sheath.

A medical device capable of treating a carotid blockage or narrowing with multiple therapeutic devices simultaneously, comprising an arch-fulcrum support catheter tube having at least one lumen from a proximal port to a distal end hole for delivering additional medical devices, a second lumen to inflate at least one distal, circumferential balloon or swellable, circumferential hydrogel, capable of temporary occlusion of native flow in a vessel near its distal end hole upon inflation, a wire for delivery of additional devices, a second balloon for angioplasty, at least one stent. Flow is allowed through said proximal port, flow across said vascular narrowing is reversed, thereby allowing debris released during angioplasty and stenting to flow out of said catheter, avoiding potential thromboembolic complications in the distal vasculature, and associated embodiments.

Systems and methods for treating thrombosis and or emboli in a peripheral vasculature of a patient are disclosed herein. The method can include providing a thrombus extraction device including a proximal self-expanding coring portion formed of a unitary fenestrated structure and a distal expandable tubular portion formed of a braided filament mesh structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus in a vessel; deploying the thrombus extraction device from the catheter from a constrained configuration to an expanded configuration; retracting the thrombus extraction device proximally so that the coring portion cores and separates a portion of the vascular thrombus from the venous vessel wall while the mesh structure captures the vascular thrombus portion; and withdrawing the thrombus extraction device from the patient to remove the vascular thrombus portion from the vessel.

An implantable prosthetic valve has an in situ formable support structure. The valve comprises a prosthetic valve, having a base and at least one flow occluder. A first flexible component is incapable of retaining the valve at a functional site in the arterial vasculature. The first component extends proximally of the base of the valve. A second flexible component is incapable of retaining the valve at a functional site in the arterial vasculature. The second component extends distally of the base of the valve. At least one rigidity component combines with at least one of the first and second flexible components to impart sufficient rigidity to the first or second components to retain the valve at the site.

A filter device is capable of reliably capturing emboli and air bubbles and reliably removing the captured emboli out of the body. The filter device includes: a first tube; a second tube protruding from the first tube; a filter arranged such that the distal end side of the filter in the longitudinal direction forms an opening; a ring fixed to the opening; first wires protruding from the distal end side of the first tube in the longitudinal direction thereof; and second wires protruding from holes in the first tube and fixed to the ring; wherein the opening can be opened and closed in the form of a bag when the proximal end side of the filter in the longitudinal direction is defined as the bottom, and the opening can be closed by pulling the second tube towards the proximal end side in the longitudinal direction.