Corneal augmentations designed for the amelioration of an abnormality of a cornea and methods of using them are disclosed. The corneal augmentations are shaped from corneal templates. The required arcuate 3-D shapes of the corneal augmentations are determined based on elevation maps of the cornea as well as measurements of a severity of the abnormality such as the maximum keratoconus, K-max. Shaping of the corneal augmentation is done using computer-controlled femtosecond lasers and laser ablation.

The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cells and any combination thereof. The present invention further discloses compositions, methods for production, implementation and treatment of medical indications by aforesaid corneal graft.

An ophthalmological treatment apparatus for resecting a patient cornea element form a patient cornea in posterior lamellar keratoplasty, an ophthalmological manufacture apparatus for manufacturing from a donor cornea a cornea implant, as well as corresponding manufacture and implantation methods are disclosed. The patient cornea cut pattern that is implemented in the patient cornea defines a patient cornea interlocking structure, the patient cornea interlocking structure being configured to interlock the patient cornea with a cornea implant after replacing the patient cornea element by the cornea implant. The corneal implant may have a corresponding cornea implant interlocking structure. The patient cornea interlocking structure and the cornea implant interlocking structure may be arranged at the posterior side of the patient cornea element and the cornea implant, respectively. The ophthalmological treatment apparatus and the ophthalmological manufacture apparatus may include in each case an ophthalmological laser device, in particular with a femtosecond laser source.

Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

A training cornea adapted to train physicians how to position a corneal inlay within a cornea, and methods thereof. The training cornea having a pre-made flap therein and having a base curvature with a radius of curvature that is the same as the radius of curvature training ball. The training cornea comprising a hydrophilic material.

A method of packaging amniotic membrane that maintains its structure to be used as a graft includes attaching the amniotic membrane to a support, dimensioning the amniotic membrane together with the support through an inert cutting device or guillotine, gluing the amniotic membrane together with the support to the interior of a container, and sterilizing the amniotic membrane. A packaged amniotic membrane includes a dimensioned sterilized amniotic membrane attached to a support, wherein the amniotic membrane is glued together with the support to a rigid, sterilized container.

The present invention relates to a deformable object to be implanted into a surgical site (exemplified by but not limited to a cornea lenticule, e.g., that could be native corneal tissue or a synthetic or biosynthetic construct), surgical instrumentation for altering the curvature and arc length of the deformable object to be implanted (e.g. corneal lenticule), as well as methods for introduction of the deformable object into the specifically prepared wound bed and for introduction of the deformable object.

A keratoprosthesis includes an anterior collagen layer made of transparent synthetic collagen, and a hydrophobic posterior layer, an anterior surface of the posterior layer being posterior of an anterior surface of the collagen layer.

A system for forming corneal implants includes a first cutting apparatus configured to cut a donor cornea and form a portion of corneal tissue. The donor cornea includes an anterior surface and a posterior surface. The first cutting apparatus is configured to cut the donor cornea along an axis extending between the anterior surface and the posterior surface. The system also includes a second cutting apparatus configured to form a plurality of lenticules from the portion of corneal tissue by making, to the portion of corneal tissue, a series of cuts transverse to the axis. Corneal tissue between consecutive cuts by the second cutting apparatus provides a corresponding lenticule to be shaped for a corneal implant. A distance between the consecutive cuts defines a thickness for the corresponding lenticule.

A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in fluid flow limiting relation to the posterior cornea through an incision in the eye and securing it in place by a variety of steps such as corneal insertion or laser bonding, and preferably by inserting a removable corneal implant including a central region and a plurality of retention member(s) disposed on the periphery thereof into the eye so as to releaseably and removably engage a portion of the eye and thereby retain the corneal implant in abutting and engaging relation with the posterior cornea. The retention members of the corneal implant may also comprise haptic leg(s) extending from the central region.