A modified, novel surgical technique of Boston Keratoprosthesis (B-KPro) Type II is provided to restore the visual acuity in patients with bilateral end-stage ocular surface disorders, comprising 1) Preparing auricular cartilage; 2) Exposing corneal stroma and sclera surface and removing the corneal epithelium; 3) Assembling the keratoprosthesis device; 4) Implanting the assembled device into recipient cornea; 5) Implanting the autologous cartilage; and 6) Suturing the Tenon's capsule and conjunctiva to the ocular surface layer by layer to cover and reinforce the KPro.

Delivery devices, carriers, and methods for endothelial keratoplasty surgical procedures are provided. The delivery devices include a flat chamber sized to accommodate thin ophthalmic tissue used in Descemet's Membrane Endothelial Keratoplasty (DMEK) procedures while the ophthalmic tissue is in a trifolded configuration with the endothelial cells facing inward. One end of the delivery devices is configured for insertion into a patient's eye to inject ophthalmic tissue. Carriers include a container and a cap configured to seal an opening of the container. The carrier is sized to accommodate a delivery device disposed within the container for storage and transport of ophthalmic tissue.

A dissection system for corneal transplants includes a housing including a contact side to be positioned against a cornea. The housing includes an interior passageway with an opening at the contact side. The dissection system includes a blade assembly disposed in the interior passageway. The blade assembly includes a first blade and a second blade. The first blade includes a first cutting edge and the second blade includes a second cutting edge. The first blade and the second blade are movable relative to the housing such that the first cutting edge and the second cutting edge extend through the opening of the housing and out of the interior passageway. The first cutting edge produces a first cut in the cornea. The second cutting edge produces a second cut in the cornea. The first cut and the second cut define a volume of tissue for removal from the cornea.

A system includes a scleral prosthesis and an insert. The scleral prosthesis includes a first end configured to be pulled through a scleral tunnel in an eye and a second end. Each end is wider than a middle portion of the scleral prosthesis. Two portions form the first end of the scleral prosthesis, and the portions are separated along at least half of a length of the scleral prosthesis. The scleral prosthesis is formed from a single integrated piece of material. The second end is undivided. The insert is configured to be placeable between the two portions. The two portions may be separated from one another without external interference, and the two portions may be configured to be pushed towards each other in order to reduce a width of the first end and then separate after release.

A method of corneal implantation with cross-linking is disclosed herein. In one or more embodiments, the method includes the steps of: (i) forming a flap in a cornea of an eye so as to expose a stromal tissue of the cornea underlying the flap; (ii) pivoting the flap so as to expose the stromal tissue of the cornea underlying the flap; (iii) inserting an implant under the flap so as to overlie the stromal tissue of the cornea; (iv) applying laser energy and/or microwaves to the implant in the eye so as to modify the refractive power of the implant; (v) applying a cross-linking solution that includes a photosensitizer to the implant; (vi) covering the implant with the flap; and (vii) irradiating the implant so as to activate cross-linkers in the implant, and thereby cross-link the implant and the stromal tissue of the cornea surrounding the implant.

A device for the transplantation of a Descemet's membrane includes a longitudinal tube having an inner cavity, an inlet opening through which it is possible to introduce the Descemet's membrane into the device, and an outlet opening through which it is possible to eject the Descemet's membrane from the device, especially into the anterior eye chamber of a patient, wherein the device also includes, at least in the region of the outlet opening, a separation element which protrudes from the inner wall region of the tube into the cavity, especially a first separation element, the separation element dividing the cavity at least regionally, in particular dividing it in a region close to the separation element.

Bioprosthetic retinal grafts (or devices) comprising stem cell derived tissues and/or cells may be used to slow the progression of retinal degenerative disease, slow the progression of retinal degenerative disease after traumatic injury, slow the progression of age related macular degeneration (AMD), prevent retinal degenerative disease, prevent retinal degenerative disease after traumatic injury, prevent AMD, restore retinal pigment epithelium (RPE), photoreceptor cells (PRCs) and retinal ganglion cells (RGCs) lost from disease, injury or genetic abnormalities, increasing RPE, PRCs and RCGs, treat RPE, PRCs and RCG defects in a subject, or for other purposes. Bioprosthetic retinal grafts may comprise a bioprosthetic carrier or scaffold suitable for implantation into the ocular space of a subject's eye, to form a bioprosthetic retinal patch. In certain embodiments, the bioprosthetic retinal patch may comprise multiple pieces of stem cell derived tissues or cells on a carrier or scaffold, which may be used to treat large areas of retinal degeneration or damage, or for other purposes.

An implantation device includes an elongated tube having a first end portion, an opposing second end portion, and a third tapered portion connecting the first and second end portions. The first end portion includes a first opening and an angled tip. The second end portion includes a second opening, and the second end portion is wider than the first end portion. The implantation device also includes a rod inserted through the first opening and extending out of and away from the first end portion. The rod includes a tapered and rounded end. The second end portion is configured to receive a scleral prosthesis into the second opening and to release the scleral prosthesis from the second opening.

Assemblies for storing, handling, transporting, viewing, evaluating, and/or shipping corneal tissue are provided. The assembly includes a corneal tissue carrier within a vial, the transport vial removably coupled to a stabilization base, wherein the ease of access to the graft carrier allows administering the corneal tissue sample to a patient in rapid succession so that more surgeries can be performed by a single surgeon in a single day.

A method of forming and implanting a synthetic corneal lenslet in an eye of a patient includes the steps of: forming a synthetic lenslet from a collagen solution using a mold or a 3-D printer that are configured to form the synthetic lenslet into a predetermined shape for correcting a particular refractive error of the patient; forming a cavity for receiving the synthetic lenslet in the cornea of the eye of the patient; inserting the synthetic lenslet into the cavity of the eye; applying a photosensitizer into the cavity of the eye so that the photosensitizer permeates at least a portion of the tissue surrounding the cavity and at least a portion of the synthetic lenslet; and irradiating the cornea so as to activate cross-linkers in the synthetic lenslet and cross-linkers in the portion of the tissue surrounding the cavity, and thereby prevent an immune response.