Compositions and methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity.

A prosthesis has a tubular body having a proximal end, a distal end, and a lumen extending through the tubular body and open at each of the proximal end and the distal end. The tubular body defines a longitudinal axis and has a first width in a direction perpendicular to the longitudinal axis. The prosthesis also includes a first flange at one of the proximal end and the distal end with the lumen extending through the first flange. The first flange has a second width in the direction perpendicular to the longitudinal axis that is greater than the first width. The tubular body and the first flange form a structurally self-supporting, body compatible, and body absorbable device. The device is formed of a composite structure and is adapted for insertion into an opening through a tympanic membrane.

A middle ear prosthesis coupling member is described that includes a transducer coupling element adapted for coupling to a mechanical signal transducer, and an ossicle fastener coupled to the transducer coupling element and adapted for secure attachment to the short process of the incus ossicle of a patient middle ear. The ossicle fastener includes parallel separated first and second fastener clips. Each fastener clip has two opposing bendable legs adapted for forming an interior region for receiving the short process of the incus ossicle and a relieved opening between opposing leg ends displaceably providing access for the incus ossicle to the interior region. The fastener clips securely enclose the short process of the incus ossicle within the interior region. The first fastener clip is adapted for exerting a force to pull the ossicle fastener toward the short process of the incus ossicle. The second fastener clip is adapted for holding the ossicle fastener in place over lateral movement on the short process of the incus ossicle only and without substantially exerting a force to pull the ossicle fastener toward the short process of the incus ossicle.

A device for use in the repair of an ear drum in a subject in need of such treatment, said device: having a tensile strength Youngs Modulus between approximately 12.5 and 40 MPa; comprising one or more membrane layers, wherein at least one membrane layer comprises a plurality of pores; and wherein the device can support proliferation, migration and/or adhesion of cells selected from the group comprising at least any one or more of: keratinocytes, fibroblasts, vascular cells, mucosal epithelial cells, and stem cells.

A system includes an interface assembly and electronic circuitry. The interface assembly is configured to receive DC power and a self-clocking differential signal comprising a data signal encoded with a clock signal at a clock frequency. The electronic circuitry is configured to recover, from the self-clocking differential signal, the data signal and the clock signal at the clock frequency, and to generate, based on the recovered clock signal at the clock frequency, a synthesized clock signal at a carrier frequency. The electronic circuitry is also configured to use the synthesized clock signal to wirelessly transmit, to an implantable stimulator implanted within a recipient, AC power based on the DC power and forward telemetry data based on the recovered data signal. Corresponding systems, methods, and devices are also disclosed.

An apparatus is provided which includes a planar body including an osseointegrating material and at least one hole configured to receive at least one protrusion of a subcutaneous acoustic transducer device. The body is configured to be implanted in contact with a portion of a bone of a recipient.

Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a therapeutic agent, for example, to the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

A support can be configured for placement in the middle ear to couple a transducer to the round window, such that the transducer can be removed from the round window without damaging the round window. The support can be configured to couple the transducer to the sound window such that the support can be removed from the round window. The support may be configured to decouple the transducer from the round window such that the transducer can be removed from the middle ear of the user, for example when the support is affixed to the middle ear. Removal of the transducer from the middle ear without damaging the round window can allow safe removal of the transducer, for example when the patient wishes to receive MRI imaging.

Medical devices for repairing defects in tissue, such as perforations in the tympanic membrane of an animal, methods of manufacturing medical devices, methods of implanting a medical device in a defect in a tissue; and methods of repairing a defect in a tissue are described. In one form, a medical device includes an overlay member having multiple arms and defining an overlay member passageway, an underlay member having multiple flaps and defining an underlay member passageway, and a securement member extending through the overlay member passageway and the underlay member passageway. In methods, the multiple flaps of the underlay member can be sequentially advanced into a defect in a tissue, such as a perforation in a tympanic membrane of an animal.

A system includes electronic circuitry that receives a self-clocking differential signal comprising a data signal encoded with a clock signal at a dock frequency. The electronic circuitry is configured to recover, from the self-docking differential signal, the data signal and the dock signal. Then, based on the recovered dock signal, the electronic circuitry is configured to wirelessly transmit, to an implantable stimulator implanted within a recipient, a forward telemetry signal representing data recovered from the data signal. Corresponding systems, methods, devices, and application specific integrated circuits (ASICs) are also disclosed.