A multi-function device useful in a surgical procedure for implanting a cartilage repairing implant in a bone is disclosed. The device includes a plurality of bone defect sizing rings or discs, where each bone defect sizing ring/disc includes a portion that is used to determine the size that correlates to the perimeter shape and size of the cartilage repairing implant. The inventive device also includes a feature that can be used to gauge the proudness of the cartilage repairing implant after the implant has been implanted into a bone.

Disclosed herein is a toe implant for replacing a portion of a human toe joint, as well as a related kit, surgical method, and method of manufacturing. Specifically, the toe implant may include a bearing member having a curved interface surface and a fixation member coupled to the bearing member. The fixation member may include a first portion having a non-porous barrier, and a tapered second portion.

An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone includes a first guide configured to be coupled generally to the first bone. The first guide includes a body portion defining a channel configured to receive a pin, wherein the pin is configured to penetrate and form a longitudinally disposed bore within the first bone. The implant resection system further includes a second guide configured to be coupled generally perpendicular to the first bone proximate to the defect by way of the bore. The second guide includes a drill bit configured to form an excision site through a portion of the articular surface in preparation of receipt of an implant.

Provided is a polymeric auricular scaffold for use in auricular implants and methods for making them. The disclosed polymeric auricular scaffold is formed using a biocompatible polymer sheet that is vacuumed formed into a shape representing auricular cartilage using a vacuum forming mold.

Methods and apparatus for delivering a sheet-like implant to a target site including a means of deploying and orienting the sheet-like implant within the body.

Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII). ##STR00001##

To replace costal cartilage that has been surgically removed, a surgeon can implant a flexible element to connect a rib to the sternum. In some examples, the flexible element can be formed from a material having a selected durometer (e.g., a measure of material stiffness or hardness), and can be shaped to have a selected geometry (e.g., cross-sectional size and shape), to match the flexibility (e.g. resistance to bending) of the natural costal cartilage. The flexible element can connect to the rib via a rib bracket, which can be rigid, and can attach to a sternal end of the rib via one or more fasteners. The flexible element can connect to the sternum via a sternum bracket, which can also be rigid, and can also attach to the sternum via one or more fasteners. The fasteners can be screws, nails, staples, or others.

A joint replacement system for repairing an articular surface of a first bone of a joint includes an anchor portion and an implant portion. The anchor portion includes an anchor to be secured to the bone, and an anchor fixation head including a bone-facing surface (BFS) extending radially outward from the anchor and an implant facing surface (IFS) extending from a periphery of the BFS. The implant portion is formed from a material (e.g., CoCr) more dense than the material of the anchor portion (e.g., Ti) and includes a fixation cavity to receive at least a portion of the anchor fixation head (AFH), the fixation cavity includes an anchor facing surface (AFS) configured to form a frictional connection with the IFS, and a load bearing surface having a contour for articulating against a cooperating articulating surface of a second bone of the joint.

A pre-sutured allograft construct and method of manufacture for repairing, replacing, reconstructing, or augmenting a hip or shoulder labrum may include a folded tissue portion extending from a first end to a second end and forming top, middle, and bottom folds. A stitched pattern secures the folded tissue portion into a graft roll having an overall length extending from a first adjustable region, through a central region, and through a second adjustable region. A continuous series of whip stitches extends from the first adjustable region, through the central region, and through the second adjustable region. A series of triple circumferential stitches overlays the whip stitches in the first and the second adjustable regions, while a series of circumferential stitches alternates with the whip stitches in the central region. The construct is pre-manufactured as an allograft product, but is adjustable during the surgical procedure within the body. Other embodiments are also disclosed.

In some embodiments, the present invention provides tissue grafts, such as vascularized bone grafts, and methods for preparing and using such tissue grafts. In some embodiments the tissue grafts are made using pluripotent stem cells, such as autologous pluripotent stem cells. In some embodiments, the tissue grafts are made by creating a digital model of a tissue portion to be replaced or repaired, such as a bone defect, partitioning the model into two or more model segments, and then producing tissue graft segments having a size and shape corresponding to that of the model segments. Such tissue graft segments may be assembled to form a tissue graft having a size and shape corresponding to that of the tissue portion to be replaced or repaired.