Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.

A novel and improved elbow prosthesis and method of implanting same including a novel aggregate prosthesis having a retaining system in conjunction with a set plate.

Nanostructured surfaces on selected substrates are described which are highly resistant to cell adhesion. Such surfaces on medical implants inhibit fibroblast adhesion particularly on nanorough titanium deposited on smooth silicone surfaces. The nanostructured deposited metal coatings can also be engineered so that several cell types, including endothelial, osteoblast, and fibroblast cells, show little if any tendency to attach to the coated surface in vivo.

The present invention relates to a stabilized ankle prosthesis configured for use in patients with compromised soft tissue in the ankle. The prosthesis of the present invention is a two-component design comprising a stabilizing lip configured to constrain movement in the general direction of compromised soft tissue.

An alloprosthetic composite implant comprising includes a structural porous scaffold having a pore density profile corresponding to a density profile of bone to be replaced. A plurality of cells are seeded within pores of the porous scaffold and grown by incubation. The cells may include osteoblasts and/or stem cells to form the structure of the implant, and one or more cartilage layers may be grown on top of the scaffold. The pore density profile of the scaffold may be formed based on one or both of the bone density profile of the bone to be removed, and the bone density profile of the native bone that will be in contact with the alloprosthetic implant. A robot may be employed reo resect the native bone and also to shape the alloprosthetic implant to fit into place in the native bone.

A revision-implant receiver (18) is provided for supporting an implant (20) of a revision joint replacement (10). The revision-implant receiver (18) comprises a first receiver element (22) and a second receiver element (24). The first receiver element (22) and the second receiver element (24) are engaged with each other via a hinge element (26).

The present invention is directed to a hinge joint implant (40) configured to fit in a joint cavity and which can comprise, when in situ, an at least hemi-spherocylindrical configuration, and further a hinge joint implant configured to fit in a joint cavity wherein the implant can extend around the sides of a joint component which may be a bone and/or cartilage. The invention further provides the use of a hinge joint implant according for treating arthritis, and/or torn cartilage, and a method for manufacturing a hinge joint implant from one or more pieces.

A tibial implant includes one or more stiffness-modifying features to reduce the stiffness of one or more sections of the tibial implant. The stiffness-modifying features may include slots, recesses, or passageways defined in various locations of the tibial implant to selectively reduce the stiffness of a tibial insert and/or tibial base of the tibial implant.

An orthopaedic implant includes: a base including a molding material; a first porous ingrowth material region coupled to the base; a second porous ingrowth material region coupled to the base; and at least one barrier insert coupled to the base, the barrier insert including a barrier material that is configured to prevent introduction of the molding material of the base into some pores of the first porous ingrowth material region and some pores of the second porous ingrowth material region during molding of the base.

The present invention discloses a connected structure of a porous surface structure and a substrate, a method for preparing the same, and a prosthesis of the same. The connected structure consists of a pre-connected or integrally formed composite body of a porous surface structure and an intermediate; and a substrate, which is connected to said intermediate to achieve the connection of said composite body to the said substrate; the composite body comprising a first composite region corresponding to a first stiffness; a remaining composite region in the composite body other than the first composite region, which at least contains a second composite region corresponding to a second stiffness; and the first stiffness is less than the second stiffness. The present invention achieves a fastened connection between the composite and the substrate and largely maintains the mechanical properties of the substrate; and it provides a prosthesis with excellent bone ingrowth properties and that the strength of the substrate is not substantially affected.