Method, executed by a computer, for identifying a coronary sinus of a patient, comprising: receiving a 3D image of a body region of the patient; extracting 2D axial images of the 3D image taken along respective axial planes, 2D sagittal images of the 3D image taken along respective sagittal planes, and 2D coronal images of the 3D image taken along respective coronal planes; applying an axial neural network to each 2D axial image to generate a respective 2D axial probability map, a sagittal neural network to each 2D sagittal image to generate a respective 2D sagittal probability map, and a coronal neural network to each 2D coronal image to generate a respective 2D coronal probability map; generating, based on the 2D probability maps, a 3D mask of the coronary sinus of the patient.

The present disclosure provides a system for predicting diabetic retinopathy progression. The system includes an image-capturing module and a processing unit. The image-capturing module is configured to capture a first fundus image of a user at a first time and a second fundus image of the user at a second time different from the first time. The processing unit is configured to receive the first fundus image and the second fundus image, compare the first fundus image and the second fundus image and indicate a difference between the first fundus image and the second fundus image. The processing unit is also configured to provide a prediction in a diabetic retinopathy progression of the user based on the difference. A method for predicting diabetic retinopathy progression is also provided in the present disclosure.

Provided herein are methods and systems for making patient-specific therapy recommendations of a combination of any two or more therapies selected from a lipid-lowering therapy, an anti-inflammatory therapy for patients with known or suspected cardiovascular disease, such as atherosclerosis.

Methods for automated segmentation system for retinal blood vessels from optical coherence tomography angiography images include a preprocessing stage, an initial segmentation stage, and a refining stage. Application of machine-learning techniques to segmented images allow for automated diagnosis of retinovascular diseases, such as diabetic retinopathy.

A method and device are for automatic determination of the change of a hollow organ. The method includes providing a first medical image of the organ recorded at a first time; computing a first representation of the organ in the first image; computing a first reference-line of the organ based on the first representation and providing a second medical image of the organ recorded at a second point. The method further includes computing a second representation of the organ in the second image; computing a second reference-line of the organ based on the second representation of the organ; registering of the first and second reference-line to obtain at least one of matched representations of the organ and features derived from the matched representations of the organs; and comparing at least one of the matched representations of the organs and the features derived from the matched representations of the organ.

Systems and methods for detecting aortic aneurysms using ensemble based deep learning techniques that utilize numerous computed tomography (CT) scans collected from numerous de-identified patients in a database. The system includes software that automates the analysis of a series of CT scans as input (in DICOM file format) and provides output in two dimensions: (1) ranking CT scans by risks of adverse events from aortic aneurysm, (2) providing aortic aneurysm size estimates. A repository of CT scans may be used for training of deep neural networks and additional data may be drawn from localized patient information from institutions and hospitals which grant permission.

A method for reproducing a lumen curve to a given tolerance in at least one image in optical coherence tomography (OCT). Examples of applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, cardio applications, and being obtained via one or more optical instruments, such as, but not limited to, catheters. The method may include obtaining a set of original points of the curve that correspond to measurements from an optical imaging device. Filtering the set of original points using at least one criteria to obtain a subset of original points. The method may also include determining if the subset of original points is less than a predetermined threshold and adjusting the at least one criteria to increase an amount of original points included in the subset of original points when it is determined that the subset of original points is less than the predetermined threshold.

There is provided a method of training a machine learning model, comprising: for each set of sample medical images depicting calcification within a target anatomical structure wherein each set includes non-contrast medical image(s) and contrast enhanced medical image(s), correlating between calcifications depicted in the target anatomical structure of the contrast enhanced image(s) with corresponding calcifications depicted in the target anatomical structure of the non-contrast medical image(s), computing calcification parameter(s) for calcification depicted in the respective target anatomical structure, labelling each contrast enhanced medical image with the calcification parameter(s), and training the machine learning model on a training dataset that includes the contrast enhanced medical images of the sets, each labelled with ground truth label of a respective calcification parameter(s), for generating an outcome indicative of a target calcification parameter(s) for calcification depicted in the target anatomical structure of a target contrast enhanced medical image provided as input.

Provided herein are methods and systems for making patient-specific therapy recommendations of a lipid-lowering therapy for a patient with known or suspected atherosclerotic cardiovascular disease, such as atherosclerosis.

The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.