A sleep mask is created comprising a sleep mask cover that can accommodate a weighted mask component and a thermal mask component. The sleep mask cover may include a fastening mechanism at the opening which may be removably engaged or disengaged to disable or enable, respectively, access to the opening for insertion of the weighted mask component and the thermal mask component. The weighted mask component may include a set of eye panels that are devoid of weight material to prevent unwanted pressure on a human user's eyes when the sleep mask is worn around the head of a human user. Further, the weighted mask component may include a pocket for insertion of the thermal mask component.

A heating device is provided comprising: a wearable layer conformable to a part of a user's body; a heat source attached to the wearable layer for applying heat to a region of a user's body; a blood flow sensor attached to the wearable layer configured to detect a parameter indicative of blood flow in or adjacent to the region of the user's body and generate a signal indicative thereof; and one or both of: (i) a processor in electrical communication with the blood flow sensor for determining the blood flow in or adjacent to the region of the user's body based upon the signal; or (ii) a transmitter for transmitting the signal to a remote device.

A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.

Treatment systems, methods, and apparatuses for treating acne, hyperhidrosis, and other skin conditions are described. Aspects of the technology can include cooling a surface of a patient's skin and detecting changes in the tissue. The tissue can be cooled a sufficient length of time and to a temperature low enough to affect glands or other targeted structures in the skin.

A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.

Treatment systems, methods, and apparatuses for treating acne, hyperhidrosis, and other skin conditions are described. Aspects of the technology can include cooling a surface of a patient's skin and detecting changes in the tissue. The tissue can be cooled a sufficient length of time and to a temperature low enough to affect glands or other targeted structures in the skin.

A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.

A skin treatment mask including a length of material configured to approximate a body surface, the length of material including a first cloth layer configured to retain moisture, a second rubber-like layer secured atop the first cloth layer, and a third resilient layer secured atop the second rubber-like layer. A kit including the mask and a method of use are also disclosed.

The present invention relates to a system (1) for applying at least two kinds of liquid onto respective targeted areas of a substrate (S). The system (1) includes first and second storage unit (10a, 10b) that accommodate first and second liquids (F.sub.1, F.sub.2); a pressured gas supply unit (20) that is fluidly connected to the first and second storage unit (10a, 10b); first and second applicator (30a, 30b) that are fluidly connected to the first and second storage unit (10a, 10b); and a controller (40) that is operatively connected to the applicator (30a, 30b). The pressured gas supply unit (20) causes pressure of a pressured gas to act on the liquids (F.sub.1, F.sub.2) within the storage unit (10a, 10b). The first and second applicator (30a, 30b) each include at least one nozzle (300a, 300b) disposed so as to face the substrate (S). The first and second applicator (30a, 30b) spray the first and second liquids (F.sub.1, F.sub.2) within the first and second storage unit (10a, 10b) from the nozzles (300a, 300b) toward the substrate (S) by the action of the pressured gas from the pressured gas supply unit (20). The controller (40) individually controls the first and second applicator (30a, 30b) so that the first applicator (30a) sprays the first liquid (F.sub.1) toward a targeted area for the first liquid (F.sub.1) on the substrate (S) and the second applicator (30b) sprays the second liquid (F.sub.2) toward a targeted area for the second liquid (F.sub.2) on the substrate (S). The present invention also relates to a method for applying at least two kinds of liquid onto respective targeted areas of a substrate (S).

A heating device is provided comprising: a wearable layer conformable to a part of a user's body; a heat source attached to the wearable layer for applying heat to a region of a user's body; a blood flow sensor attached to the wearable layer configured to detect a parameter indicative of blood flow in or adjacent to the region of the user's body and generate a signal indicative thereof; and one or both of: (i) a processor in electrical communication with the blood flow sensor for determining the blood flow in or adjacent to the region of the user's body based upon the signal; or (ii) a transmitter for transmitting the signal to a remote device.