Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

The present disclosure relates to a cold and hot thermal treatment device. Hot heat and cold heat are produced by a heat production unit and are periodically and repeatedly transferred to a heat transfer unit that is in contact with a human body such that a temperature is not suddenly changed but is gradually changed. Thus, the device may be used when diagnosing whether vascular reactivity is maintained in corresponding hands and feet, may generate a temperature stimulus, and may repeatedly perform the temperature stimulus, thereby improving the vascular reactivity.

An appendage cooling and heating system has a body with an outer layer, an inner layer, and an interstitial space for containing a thermo-regulator material. The inner layer and the outer layer are nested to form a joint. An appendage opening is formed in the appendage cooling and heating system to receive an appendage of the user. The joint forms an interlocking seal between the outer layer and the inner layer to contain the thermo-regulator material within the interstitial space.

Support device (1) for supporting at least one body part of a user at least in portions, optionally completely, comprising a support body (2), which comprises at least one support region (3) for supporting at least one body part of a user at least in portions, optionally completely, wherein at least the support region (3) has, at least in portions, optionally completely, a geometric-structural design that is individually configured on the basis of the data describing at least one body part of a user that is to be supported on the support region (3) at least in portions, optionally completely.

The present application relates to systems and methods for altering temperature in a mammalian body. Optionally, the systems and methods can be used to lower or raise core body temperature of a mammalian subject. Optionally, the systems and methods can be used to lower or raise the temperature of glabrous skin of a mammalian subject.

Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

Methods for transcutaneous heat transfer are provided. Aspects of the methods include stably associating a glabrous skin surface of a mammal with a thermoregulatory device configured to be associated with only a portion of a limb of the mammal and transferring heat through the glabrous skin surface without application of negative pressure. Also provided are devices, systems and kits that find use practicing the methods. The methods and compositions described herein find use in a variety of different applications, including maintaining normothermia, e.g., in thermoregulatory compromised individuals.

Systems and methods for improving or preventing a condition, such as the treatment of pain syndromes and migraine headaches are disclosed. A method for treating pain can include one or more of the steps including identifying a region of the patient comprising glabrous tissue; positioning the region of the patient comprising glabrous tissue into an enclosed chamber; adjusting the relative humidity of the enclosed chamber sufficient to create a physiologic effect. The method need not involve altering the temperature within the enclosed chamber.

Systems and methods for affecting metabolism, such as the treatment of metabolic syndrome are disclosed. A method for treating metabolic syndrome can include one or more of the steps including identifying a region of the patient comprising glabrous tissue; positioning the region of the patient comprising glabrous tissue into an enclosed chamber; adjusting the relative humidity of the enclosed chamber sufficient to create a physiologic metabolic effect; and activating a convection fan within the chamber to promote heat transfer from the glabrous tissue. The method need not involve altering the temperature within the enclosed chamber.

Embodiments disclosed include systems, methods, and apparatuses, directed to administering thermal neural modulation to mammalian tissue to control nerve conduction. Embodiments disclosed include an apparatus comprising a thermal energy source, a first heat exchanger coupled to the thermal energy source and configured to receive thermal energy therefrom, a thermal applicator configured to be disposed and secured to the anatomy of a subject having a nerve therein, in contact with the skin on the anatomy and overlying a treatment portion of the nerve, the thermal applicator configured to transfer thermal energy to the skin to raise the temperature of the treatment portion of the nerve above a physiologic temperature, a second heat exchanger is coupled to the thermal applicator and configured to transfer thermal energy thereto, and a fluid conduit having a first portion coupled to the first heat exchanger and a second portion coupled to the second heat exchanger. The fluid conduit is configured to have fluid circulated therethrough to convey thermal energy from the thermal energy source via the first heat exchanger and to the thermal applicator via the second energy at a temperature.