The present disclosure relates to a complex having a core-shell structure, a composition and a textile comprising the same, and a method for treating thrombosis, cancer, or wounds using the same. The complex having the core-shell structure comprises a core; and a shell layer covering a surface of the core; wherein the core is made of polypyrrole.

A cooling system (10) for cooling at least one extremity, such as a finger or toe, or body part of a human is provided. The cooling system (10) comprises at least one malleable thermal conductive viscoelastic material (11), adapted to be formed into a homogenous body around and fully covering the at least one extremity or body part, thereby providing for a complete and continuous direct contact between the malleable thermal conductive viscoelastic material and the at least one extremity or body part. Moreover, the cooling system (10) comprises a cooling circuit (12) for providing cooling at least partly around said homogenous body of malleable thermal conductive viscoelastic material (11).

A mouthpiece having particular suitability for cooling oral tissue of a patient undergoing chemotherapy or other medical treatments in which reducing oral cavity temperature is beneficial. The mouthpiece includes a cooling medium contained within the top element and the bottom element and able to retain a cooling environment within the mouth, preferably sufficient to reduce capillary blood flow to the patient's mouth. In one embodiment, an external chamber extends from the front of the mouthpiece to house a cooling medium. A bladder is positioned inside the external chamber for storing a solution having a freezing temperature above the freezing point temperature of the cooling medium to assist in cooling the cooling medium. At least one breathing tube extends through the external chamber to permit a patient to breathe through the mouth when the mouthpiece is emplaced within the mouth in the operative close-fitting relationship.

A system for cooling a head of a user to mitigate or prevent drug-induced hair-loss, including a hat, which includes an exterior layer, an interior layer, with an inflatable chamber therebetween, the inflatable chamber being functionally associated with an inflation pump. The hat includes a cooling assembly, reversibly attachable to the interior layer and including a housing defining pockets having cooling pads therein. Each cooling pad comprising a phase-changing-material adapted to obtain a temperature lower than 20 C. and to retain that temperature. A sensor is adapted to sense an environmental condition within the hat. A controller is adapted to receive input from the sensor, and to provide a notification when the sensed environmental condition is outside of a specific range. When the hat is donned by the user, the inflatable chamber is inflated sufficiently to ensure that the cooling assembly engages the scalp of the user.

A cold cap adapted for connecting to a chiller unit for circulating chilled fluid through the cap. The cap is formed from at least three layers of material which are sealingly attached around their periphery so as to form a cooling fluid chamber, wherein the cap is configured to apply compression and cooling to the scalp.

A blood flow restricting apparatus is provided. The blood flow restricting apparatus can include a frame element configured to be securable to a user's head. At least one cooling pad can be operatively arranged with the adjustable frame element and configured to be arranged over a defined anatomic location including at least one of a pair of supratrochlear arteries, a pair of supraorbital arteries, a pair of temporal arteries, and a pair of occipital arteries of the user's head when the frame element is secured to the user's head. A pressurizing mechanism can be operatively arranged with the at least one cooling pad and capable of pressing the at least one cooling pad against the defined anatomic location to restrict blood flow to each of the targeted arteries while simultaneously cooling the defined anatomic location to induce hypothermic induced vasoconstriction.

A blood flow restricting apparatus is provided. The blood flow restricting apparatus can include a frame element configured to be securable to a user's head. At least one cooling pad can be operatively arranged with the adjustable frame element and configured to be arranged over a defined anatomic location including at least one of a pair of supratrochlear arteries, a pair of supraorbital arteries, a pair of temporal arteries, and a pair of occipital arteries of the user's head when the frame element is secured to the user's head. A pressurizing mechanism can be operatively arranged with the at least one cooling pad and capable of pressing the at least one cooling pad against the defined anatomic location to restrict blood flow to each of the targeted arteries while simultaneously cooling the defined anatomic location to induce hypothermic induced vasoconstriction.

A system includes a treatment cap assembly and a cooling and compression unit coupled to the treatment cap assembly. The treatment cap assembly comprises a fluid circulating pad configured to circulate a cooling fluid; and a compression hood configured to administer compression to a scalp of an individual wearing the treatment cap assembly. The cooling and compression unit is configured to provide the cooling fluid to the fluid circulating pad and to periodically provide compressed gas to the compression hood. The system can be used in a method that includes administering to an individual a dosage of a chemotherapeutic agent; cooling a scalp of the individual to a temperature of less than about 65? F.; and periodically administering compression to the scalp of the individual during the step of administering the dosage of the chemotherapeutic agent.

A composition for use in cooling therapy and treatment of chemically induced alopecia (CIA), said composition containing a reactive oxygen species (ROS) inhibitor.

The present invention is directed to a thermo-regulation device for treating an area with in need of thermal regulation. The invention includes a device configured to be fitted over an area in need of thermal regulation; wherein a plurality of cells are integral to the covering body, each cell is equipped with at least one of a plurality of reactants. Each cell of the present invention is in one configuration joined to a neighboring cell by a destructible barrier. The reactants are configured to produce a thermal event when combined with at least one other reactant.