Disclosed are methods of using planar or defocused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Disclosed are methods of producing ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Described herein are components, systems, and methods of use of an integrated sterilization system comprising a pass-through logistics cabinet, an ozone sterilization system, a floor sterilization robot, and systems for controlling such components. An integrated operating room sterilization system will allow mitigation or elimination of risks (e.g., infrastructural risks (e.g., OI risks), procedural risks (e.g., risk of infection and contamination) that are associated with a setting in a healthcare environment. The elimination of clutter, control of major components under a unified and intuitive user interface, and the logical elimination of potential accumulated risk events (e.g., OI risks) and procedural risks are deliberately addressed, in whole or in part, by the present disclosure. The present disclosure describes the following: a pass-through logistics cabinet, an ozone sterilization system, a floor sterilization robot, and systems for controlling such components.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

The present disclosure relates to devices and methods for increasing the probability of a successful organ donation by decreasing organs' warm ischemia time. Furthermore, the present disclosure relates to increasing the pool of eligible donors, including donors who had prior chest surgeries or prior abdominal surgeries. The present disclosure provides a catheter extending through a cannula, wherein the cannula delivers cold perfusion fluid and the catheter blocks the aorta, forcing the cold perfusion fluid to pass to organs in the donor's abdomen. The present disclosure further provides for advancing the catheter from a retracted position to an extended position, and creating a watertight seal at the cannula to prevent backflow of cold perfusion fluid.

An integrated and modular air and lighting plenum that is the primary directional lighting mounting apparatus and laminar flow diffuser of an HVAC system in a healthcare setting. The plenum provides laminar air flow from the ceiling to the room in which it is located in accordance with HVAC requirements for healthcare environment settings, by using a plurality of cylindrical airflow outlets. The use of cylindrical airflow outlets promotes laminar airflow by reducing sharp boundaries that induce turbulence (e.g., the corners of rectangular or square outlets) and creates a highly sterile environment around the patient and staff in the operating room. The surgical lights used in the integrated air and lighting plenum allow the beam direction, spot size, focal point, brightness, and color temperature of the emitted light to be controlled.

A method for maintaining and/or increasing body temperature of a patient may involve delivering heat to a first location on a limb of the patient, delivering heat to a second location on the limb, apart from the first location, and applying intermittent compression to a third location on the limb, located between the first location and the second location. A device for maintaining and/or increasing body temperature of a patient may include a sleeve for positioning over at least part of one of the patient's limbs, first and second heat delivery members coupled with the sleeve, and an intermittent compression member coupled with the sleeve between the first and second heat delivery members.

A single-use patient positioning and warming pad configured to be placed between a patient and an operating table during a surgical procedure is provided. The pad includes a viscoelastic foam body having a top portion and a bottom portion; a heating element at least partially disposed between the top portion and the bottom portion of the foam body; and an electrical connector having a proximal end portion enclosed within the foam body connected to the heating element and a distal end portion extending from the foam body, configured to directly or indirectly connect to a power source and/or control unit for the heating element. Optionally, the foam body is formed from a foam material having sufficient viscosity and resiliency to maintain positioning of the patient relative to the operating table during surgical procedures in which the operating table is moved to an inclined position.

The present disclosure provides an organ supporting device and a manufacturing system thereof. The organ supporting device includes a tube with a one or more bends to create two supporting regions for an organ. The supporting regions are connected via a connecting region. The tube is supplied with temperature control material, such as a cooling fluid, by a circulation component. The temperature of the organ and fluid are sensed by one or more sensors and the sensed temperatures are provided to a temperature control unit to increase or decrease the temperature of the temperature control material to maintain a temperature of an organ for in-vivo or ex-vivo surgical procedures.

An organ container has a contractible and expandable pouch-shaped body having an opening. Under no-load conditions, the opening has a maximum width smaller than a maximum width of the body. The opening is expandable up to a state in which the maximum width of the opening is greater than the maximum width of the body. The body has an inner surface that includes a first region having a smooth curved surface and a second region having an uneven shape. The uneven shape of the inner surface of the body allows a preservation solution to protrude into interstices between an organ and the inner surface and thereby improves a thermal insulating effect. Moreover, by providing the smooth first region, generation of remaining traces can be suppressed. Accordingly, it is possible to effectively suppress a temperature rise in the organ and to reduce damage to the organ.