The present invention is directed to an absorbable hemostatic nonwoven patch that utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; with the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.

A transfer dressing that can secure and/or prevent undesired movement of epidermal skin grafts transfer substrates is described. The transfer dressing can include a transfer substrate and one or more adhesive appendages that are configured to secure the transfer substrate to a recipient site (e.g., periwound area) in order to hold the transfer substrate in place and/or facilitate handling of the transfer substrate. The transfer substrate can be comprised of a fenestrated surface configured to facilitate harvesting and transfer of epidermal skin grafts.

Dry adhesive materials, particularly in the form of a film or tape, for adhering one or more wet surfaces comprising: (i) one or more hydrophilic polymers; (ii) one or more amine coupling groups, and (iii) one or more cross linkers. The dry adhesive material, when placed in contact with the one or more wet surfaces, absorbs liquid from the one or more wet surfaces, swells to form temporary crosslinking with the wet surface, and forms covalent crosslinking with the one or more wet surfaces.

In some aspects, the present invention provides an active dressing for transfer of superficial epidermal biopsies to a wound site, where the dressing can enhance keratinocyte out growth from the biopsies at the wound site and improve the rate of re-epithelization. In some embodiments, the dressing can include a perforated dehydrated amniotic membrane sheet that is coupled to a backing sheet having suitable adhesive properties. The perforations can have appropriate dimensions and distributions for capturing and transferring the skin biopsies. Without being limited to any particular theory, the amniotic membrane sheet can enhance the re-epithelization of the wound site to which the biopsies are transferred, e.g., by supplying signaling proteins and extra-cellular matrix (ECM) components.

A dressing for treating a tissue site, particularly a peritoneal or abdominal site, is disclosed. The dressing may comprise: first and second layers, each being made from a liquid-impermeable material and being at least partially fenestrated, the layers being coupled together to define a chamber therebetween; and disposed within the chamber a third layer comprising a manifold having a central region, and a perimeter region containing perforations arranged in a pattern defining a plurality of sub-regions. The first and second layers can be coupled using a plurality of welds or bonds through the perimeter region perforations. Optionally, the manifold does not comprise, and the chamber does not contain, any manifolding elements extending outward from an outer edge of the perimeter region.

Described herein are dressings comprising a composite island comprising a polyurethane or foam layer coupled to an absorbent layer comprising non-woven gelling fibers. Also described herein are dressings comprising an absorbent layer comprising carboxymethyl cellulose fibers and a backing layer coupled to the absorbent layer. In the respective dressings, the absorbent layer is not elastically deformable under tissue treatment conditions, whereas the polyurethane or foam layer and the backing layer are substantially elastically deformable under tissue treatment conditions. The coupling of the absorbent layer to the polyurethane/foam layer or backing layer renders the coupled structure or the entire dressing substantially elastically deformable under tissue treatment conditions. Methods of eliminating, minimizing, or reducing edema are also described herein.

A wound dressing provides a tenacious occlusive seal against the skin of a wearer, even in the presence of excessive blood or heavy perspiration. The preferred embodiment combines an adhesive backing layer with a hydrogel island providing superior hydrophilic gel adhesion. The product performs under extreme temperatures (i.e., 32-140 F.), and may be used to hold other dressings in place. The preferred embodiments are entirely translucent, and include a large pull-tab for easy removal. Two dressings may be packaged in a pliable re-sealable protective pouch, thereby forming a portable kit. Different vented embodiments are disclosed. A preferred structure includes a cover layer peripherally bonded to backing and hydrogel layers having a central aperture therethrough. The cover layer has one or more vent holes, and pressure is released through the central aperture and out the vent hole(s).

This invention provides a hydrogel surgical dressing product having a designed multi-dimensional flexible hydrophilic structure-linkage composite, comprising: a hydrogel cushion layer, and a multiple of hydrophilic microsphere, wherein said multi-dimensional flexible hydrophilic structure-linkage composite comprising a hydrophilic multi-dimensional flexible structure-linkage membrane, and a multiple of structure-linkage holes positioned into said hydrophilic multi-dimensional flexible structure-linkage membrane, and the sizes of structure-linkage holes changed with the degree of compelling force, resulting in a multi-dimensional flexible structure-linkage relationship and a consolidating structure.

Dry adhesive materials, particularly in the form of a film or tape, for adhering one or more wet surfaces comprising: (i) one or more hydrophilic polymers; (ii) one or more amine coupling groups, and (iii) one or more cross linkers. The dry adhesive material, when placed in contact with the one or more wet surfaces, absorbs liquid from the one or more wet surfaces, swells to form temporary crosslinking with the wet surface, and forms covalent crosslinking with the one or more wet surfaces.

Method for the manufacture of a wound care product in which a fabric containing hydroactive constituents, in particular fibres, is processed, whereby the processing of the fabric comprises the application of an antimicrobial means onto the hydroactive constituents.