A tunable colorimetric sensor/optical filter is based on a lithography-free, asymmetric Fabry-Perot cavity. The sensor has a thin-film structure formed by a lossy, porous nanoplasmonic top film deposited on an actively tunable spacer middle layer, and a reflective base layer (either a metal or semiconductor). The structure is fabricated using wafer-scale PVD processes, and the middle layer responds to the presence of a stimulus in the local environment, by expanding in thickness resulting in a shift in resonance wavelength and thus an obvious change in color of the sensor, which color change is detectable by the naked-eye. Such layered geometries exhibit vibrant, macroscopic structural coloration owing to the broadband optical absorption of the top film, enabling the change in spacer thickness to be transduced visually, circumventing the need for sophisticated optical equipment for signal readout to observe the presence of the environmental stimulus.

Devices and methods for calculating various coagulation characteristics associated with a patients liquid test sample. The presently disclosed and claimed inventive concept(s) relate to an improved device(s) and method(s) for conducting coagulation assays on a patients liquid test sample, including, without limitation, a patients whole blood sample.

Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.

The disclosure relates to methods and systems for the analysis of compounds in a crystalline state and/or undergoing crystallization. Two-dimensional correlation (2DCOS) and co-distribution analysis (2DCDS) analysis plots can be generated and analyzed. Asynchronous plots can aid in establishing a sequential order of events. Positive cross peaks that correlate with auto peaks associated with aggregation can be identified. The auto peaks can be referenced to quickly discern the regions of the molecule most perturbed, which would indicate a driver for the crystallization state of the molecule. One can define which functional group types (e.g., region) are most perturbed (positive, intense auto peak) and observe how the different auto peaks begin to have greatest intensity change. These changes in auto peaks in the synchronous plots for the different stages of crystallization can provide information as to the dynamics of the process from amorphous to crystalline state.

According to one embodiment, a method is for generating a calibration curve based on results of photometry on a plurality of standard samples each containing a detection target in a known concentration. The concentration differs between the standard samples. The method includes obtaining the results of photometry on the standard samples at different photometry timings, to generate the calibration curve.

The present invention relates to portable devices for point-of-care diagnostics that can perform measurements on a sample (e.g., blood, serum, saliva, or urine) and relay data to an external device for, e.g., data analysis. The device can comprise a paper-based diagnostic substrate and a base substrate that include electronic circuitry and electronic elements necessary for performing the measurements. The device can also comprise an antenna for near field communication with an external device. Another aspect of the invention relates to methods of using these devices.

Systems and methods for a color board for use in reagent strip testing are disclosed. One implementation may include a color board surface, a first colored reference element printed on the color board surface, and a second colored reference element printed on the color board surface. The color board may also include a test region on the color board surface configured to receive at least one reagent pad. The color board may also include a unique code, and the code may reflect specific chromatic properties associated with each of the first colored reference element and the second color reference element at a time of printing. The unique code may be machine readable to enable a machine to later normalize a comparison color, for determining chromatic properties of the at least one reagent pad.

This invention publicly announces a quantificational testing method of semen liquefaction ability. By following the steps of sample preparation, image collection, image quantificational analysis and curve analysis to analyze the quantificational testing of semen liquefaction ability; indirectly indicate the semen liquefaction ability by observing the color depth change in the sperm sampled cover black area; to analyze the quantification of semen liquefaction by observing the level of change in grey level value versus time; thus, to efficiently, subjectively and standardly test the semen liquefaction ability and avoid human errors.

An integrated microfluidic chip, wherein at least one integrated reaction unit is provided on its substrate, and the integrated reaction unit comprises at least a sample cell (1), a mixing cell (2) and a reaction cell (3) connected through liquid channels (6). In one aspect, one end of the sample cell (1) is provided with a sample inlet (4), and the chip further comprises an internal air circulating system/circuit. One end of the internal air circulating system/circuit is connected with the mixing cell (2), while the other end comprises at least a first circulation branch circuit connected with the end of the sample cell (1) distal to the sample inlet (4).

A method for analyzing biological material includes reading in a measurement signal, a first reference signal and a second reference signal. The method further includes determining noise in the measurement signal in order to produce noise data, applying the noise data to the first reference signal and to the second reference signal in order to generate an adjusted first reference signal and an adjusted second reference signal, and transforming the measurement signal, the adjusted first reference signal, and the adjusted second reference signal into a frequency distribution form in order to produce a measurement signal distribution, a first reference distribution and a second reference distribution. Additionally the method includes performing a cluster analysis using the measurement signal distribution, the first reference distribution, and the second reference distribution to determine, in accordance with a result of the cluster analysis, whether the biological material has the first property or the second property.