A Fourier spectrophotometer includes: a light source; an interferometer configured to obtain first and second interferograms whose intensity distributions are inverted from each other from the light emitted from light source; a multiplexing optical system configured to multiplex the first and second interferograms to irradiate the sample with a resultant interferogram; a demultiplexing optical system configured to demultiplex the first and second interferograms contained in the light passing through the sample; a light receiver configured to output a first light reception signal obtained by receiving the demultiplexed first interferogram and a second light reception signal obtained by receiving the demultiplexed second interferogram; and a signal processing device configured to perform processing for obtaining a noise-removed spectrum of the wavelength component in the analysis wavelength band by using the first and second light reception signals.

Disclosed herein are systems and methods for quantifying bacteriophage virulence, measuring phage-host dynamics and parameters, including phage-host range, phage interactions with biological samples and with immune systems, and label-free bacterial detection/diagnostics, that are amenable to automation, high-throughput, and functional in complex media. In some embodiments, a label-free interferometry system transduces the light reflected by a sensor and any molecules attached thereto to a real-time signal comprising a sensorgram from which infectivity parameters such as binding kinetics and lysis time can be derived.

A colorimetric sensor for detecting an analyte of interest in a fluid sample includes a photonic structure integrated with a receptor, wherein the photonic structure may be configured such that, when an analyte contacts the receptor within the photonic structure, a refractive property of the photonic structure changes thereby to cause a detectable color change in the photonic structure. The photonic structure may comprise an optical absorber indicator, wherein the receptor may be associated with the optical absorber indicator, such that, when the analyte contacts the receptor, the analyte causes a color change of the optical absorber indicator via a photo-induced electron transfer mechanism. The optical absorber indicator may comprise the photo-induced electron transfer mechanism.

Systems and methods for improved interferometric imaging are presented. One embodiment is a partial field frequency-domain interferometric imaging system in which a light beam is scanned in two directions across a sample and the light scattered from the object is collected using a spatially resolved detector. The light beam could illuminate a spot, a line or a two-dimensional area on the sample. Additional embodiments with applicability to partial field as well as other types of interferometric systems are also presented.

Methods for determining MHC class II binding activity of a preparation comprising lymphocyte activation gene-3 (LAG-3) protein, or a fragment, derivative, or analogue thereof, is described. The methods comprise determining binding of the LAG-3 protein, fragment, derivative, or analogue to MHC class II molecules using bio-layer interferometry (BLI). Such methods can be used as a quality control assay in good manufacturing practice (GMP) grade production of such compounds. Probes and kits for carrying out the methods are also described.

A method and system for measuring a sample property (X) by means of photonic circuit (10). The photonic circuit (10) comprises at least two photonic sensors (11, 12) configured to modulate the light according to respective output signals (S1,S2) with periodically recurring signal values (V1, V2). The photonic sensors (11, 12) comprise a low range sensor (11) with a relatively low range or high sensitivity for measuring a change (X) of the sample property (X) and a high range sensor (12) with a relatively high range or low sensitivity to measure the change (X) of the sample property (X). The sample property (X) is calculated by combining the output signals (S1, S2) of the sensors (11, 12). Particularly, the second output signal (S2) of the high range sensor (12) is used to distinguish between recurring signal values (V1) in the first output signal (S1) of the low range sensor (11).

Systems and methods for improved interferometric imaging are presented. One embodiment is a partial field frequency-domain interferometric imaging system in which a light beam is scanned in two directions across a sample and the light scattered from the object is collected using a spatially resolved detector. The light beam could illuminate a spot, a line or a two-dimensional area on the sample. Additional embodiments with applicability to partial field as well as other types of interferometric systems are also presented.

The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly includes a light source to emit light signals; a light detector to detect light signals; a coupler to optically couple the light source and the light detector to a waveguide tip; a monolithic substrate having a coupling side and a sensing side; and a lens between the waveguide tip and the monolithic substrate. The lens relays optical signals between the waveguide tip and the monolithic substrate.

A defect detection method includes the following processes: a) stroboscopically illuminating the entire surface of an object within an examination area of the object while inducing a first elastic wave across the examination area on the object, and controlling the phase of the elastic wave and the timing of the stroboscopic illumination to collectively measure a back-and-forth displacement of each point within the examination area in at least three phases of the elastic wave; b) identifying a surface location which is the location of a defect on the examination area, based on the back-and-forth displacement of each point within the examination area in the at least three different phases; and c) injecting a second elastic wave into a region inside the surface location from a limited area including the surface location, and determining the location and/or size in the depth direction of the defect, based on a response wave.

The present disclosure concerns a photonic integrated circuit (10) and a method for interrogating a ring resonator (3) comprised therein. The circuit (10) comprises an optical port (4) for coupling light (L) into and out of the circuit (10). The circuit (10) further comprises a first waveguide (1) for receiving light (L1) from the optical port (4), and a second waveguide (2) for sending back light to the optical port (4). The ring resonator (3) is arranged between the first waveguide (1) and the second waveguide (2) for coupling a resonant wavelength () of the light therein between. The optical port (4) comprises a polarization splitting coupler for coupling light of a first polarization (P1) to and from the first waveguide (1) and coupling light of a second polarization (P2), orthogonal to the first polarization (P1), to and from the second waveguide (2).