A fluid delivery system and process for fluid delivery is provided that is useful in in flow-injection based sensing measurements, wherein samples from a sample rack are introduced into a flow cell where sensing measurements are taken. The system and process utilize at least two holding lines where each holding line can retain one of the samples prior to injection of the thus retained sample into a flow cell. The introduction of the samples from the sample racks to the holding lines is alternated and the injection of the samples from the holding lines to the flow cell are alternated so that one holding line is loaded with one of the samples simultaneously with another sample being injected from the another holding line to the flow cell.

The invention relates to detecting cell biomarker signatures and integrated cell biomarker-morphological profiles by detecting resonance-light scattering of functionalized nanoparticles.

There are provided a localized surface plasmon resonance sensing chip in which a linewidth of an absorption spectrum originating from localized plasmon resonance is narrow and with which a peak wavelength shift of an optical spectrum accompanying a change in refractive index of a surface can be accurately measured, and a localized surface plasmon resonance sensing system using this sensing chip. A sensing chip 10 includes a base 14 having a flat-plate shape, a plurality of protruding portions 16, and a metal layer 18 covering each front surface of the plurality of protruding portions 16. The protruding portions 16 each have a shape like a semi-oblate spheroid which is one of three-dimensional parts obtained by dividing an oblate spheroid in half along an equatorial plane and are arranged such that a divided surface 16a of the semi-oblate spheroid faces a front surface 14a of the base 14. A sensing system includes the sensing chip 10, a light source irradiating a detection region of the sensing chip 10 with light, and a photodetector detecting the optical spectrum of light emitted from the light source and then reflected in or transmitted through the detection region of the sensing chip 10.

Provided is an optical device including a dielectric transparent substrate and a metallic layer having a thickness between about 20 nm and about 1000 nm disposed on the transparent substrate. The metallic layer comprises at least one localized group of cavities, each localized group being confined within a diameter smaller than about 5 um, and each localized group comprising at least two cavities, with a distance between two adjacent cavities in the localized group being between about 100 nm and about 2000 nm. Each cavity in the localized group is shaped as a through-hole in the metallic layer, the through hole having a polygonal cross-section having a polygon side length between 50 nm and 2000 nm.

Apparatuses and methods for spectroscopy using multiple resonance modes are provided. Multiple resonance modes may be used for bulk sensing and/or surface sensing applications. A plasmon waveguide resonance sensor is provided for multimode spectroscopy. The sensor includes a dielectric layer; and a metallic layer coupled to the dielectric layer. The sensor is configured to provide: a first resonance mode for bulk sensing, in response to light of a given wavelength; and a second resonance mode for surface sensing, in response to light of the given wavelength. The first and second resonance modes have different polarizations. Surface plasmon resonance assemblies are provided having a grating coupled to a surface plasmon resonance sensor, the grating being a dielectric grating or a metallic grating. The grating, in response to light, provides various resonance modes having at least two different polarizations for bulk and surface sensing.

The present invention generally relates, in some aspects, to systems and methods for making and using sensors or other devices, such as optical components. One aspect is generally directed to a sensor or other device comprising a nanometer-sized portion. In some embodiments, the sensor can be used to determine various characteristics such as temperature, humidity, an electric field, a magnetic field, an analyte, or the like. For instance, in one embodiment, a portion of a sensor device may be inserted into a cell and used to study the cell, e.g., using optical techniques such as surface plasma resonance. In some embodiments, such sensors or other devices may comprise metal, glass, or other materials, which can be prepared using etching or other techniques.

A tunable plasmon resonator, comprising a plasmon resonance layer made of graphene, a crystalline group-IV-semiconductor material or a crystalline group-III-V semiconductor material, and arranged on a carrier substrate, the plasmon resonance layer having a plasmon resonance region that is exposed to a sensing volume and a tuning device that is integrated into the plasmon resonator and arranged and configured to modify a density of free charge carriers in the plasmon resonance region or to modify an effective mass amount of the free charge carriers in the plasmon resonance region by applying of a control voltage to tuning control electrode(s) of the tuning device, thereby setting a plasmon frequency of plasmon polaritons in the plasmon resonance region to a desired plasmon frequency value within a plasmon frequency tuning interval, for resonance excitation of plasmon polaritons by incident electromagnetic waves of a frequency corresponding to the set plasmon frequency value.

This invention relates to the rapid determination of the viral titer by contacting a solution comprising viral particles, such as lentiviral particles, comprising a heterologous envelope protein, such as VSV-G, with an immobilised receptor that binds to the envelope protein, and determining the binding of the viral particles to be immobilised receptor using surface plasmon resonance (SPR).

Improved multilayered magneto-optic-plasmonic (“MOP”) films that are used in connection with surface plasmon detection that have a first layer comprising titanium, a second layer selected from a group consisting of gold and silver, a third layer comprising cobalt, and a fourth layer comprising gold are disclosed. In an embodiment, the film has a first titanium layer with a thickness of approximately 2 nm, a second gold layer with a thickness of 35 nm, a layer of cobalt having a thickness of approximately 8 nm and a fourth gold base layer having a thickness of approximately 10 nm.

An electricity measuring type surface plasmon resonance sensor includes: a plasmon resonance intensifying sensor chip in which a prism and a sensor chip including an electrode, a silicon semiconductor film, and a plasmon resonance film electrode arranged in this order are arranged in an order of the prism, the electrode, the silicon semiconductor film, and the plasmon resonance film electrode; and an electric measuring apparatus which directly measures a current or voltage from the electrode and the plasmon resonance film electrode.