The invention relates to a device comprising a first optical Mach-Zehnder interferometric sensor (MZI1) with a large FSR, wherein a plasmonic waveguide (107) thin-film or hybrid slot, is incorporated as transducer element planar integrated on Si3N4 photonic waveguides and a second optical interferometric Mach-Zehnder (MZI2), both comprising thermo-optic phase shifters (104, 106) for optimally biasing said MZI sensor (MZI1) and MZI as variable optical attenuator VOA. It further comprises an overall chip (112), being remarkable in that it comprises a set of Photonic waveguides (103) with a high index silicon nitride strip (303, 603), which is sandwiched between a low index oxide substrate (SiO2) and a low index oxide superstrate (LTO); Optical coupling structures (102, 109) at both ends of the sensor acting as the optical I/Os; an Optical splitter (102) and an optical combiner (109) for optical splitting at the first junction (102) of said first sensor (MZI1) and optical combining at the second junction (109) of said first MZI (MZI1); a variable optical attenuator (VOA) with said additional second MZI (MZI2), which is nested into said MZI1 (sensor)), deploying an optical splitter and an optical combiner for optical splitting at the first junction of said additional second MZI (MZI2), and optical combining at the second junction of said second MZI (MZI2); a set of Thermo-optic phase shifters (104, 106) to tune the phase of the optical signal in the reference arm (104, 106) of each said MZI (MZI1, MZI2-VOA); wherein Thermo-optic phase shifters are formed by depositing two metallic stripes parallel to each other on top of a section of the photonic waveguide and along the direction of propagation of light; and a plasmonic waveguide (107) in the upper branch (103) of said first MZI (MZI1), that confines light propagation through coupling to Surface Plasmon Polaritons (SPP) at the metal-analyte interface, and method associated thereto.

A surface enhanced luminescence analyte interrogation stage may include a substrate and an array of pillars projecting from the substrate. Each of the pillars may include a polymeric post formed from a first material and a cap on the polymeric post. The cap has a plasmonic surface and is formed from a second material different than the first. A sacrificial coating covers the cap of each of the pillars.

The invention relates to a sensor module (1) for multiparametric analysis of a medium (105) and to the uses thereof. The sensor module (1) according to the invention is characterised by a combination of photonic and non-photonic measurement principles with parameter-sensitive coatings (103) on a substrate (100). A plurality of properties of a medium (105) can be detected over wide parameter ranges, wherein the most suitable method can be used for the corresponding parameter, at least for example with regard to the accuracy, the long-term stability, the resolution, the reproducibility, the energy consumption, the manufacturing costs, the necessary space requirements.

A foldable digital microfluidic (DMF) device using a flexible electronic platform and methods of making same is disclosed. The foldable DMF device includes a flexible polyimide substrate with thin copper features that is foldable to provide opposing substrates. The foldable DMF device further includes a flexible polyimide dielectric layer also with thin copper features. In some embodiments, the structure for forming the presently disclosed foldable DMF device is based on the use of blind vias. In some embodiments, the foldable DMF device includes one droplet actuation layer. In other embodiments, the foldable DMF device includes multiple droplet actuation layers. Additionally, a method of making the foldable DMF device is provided.

Various embodiments may provide an optical fiber for sensing an analyte. The optical fiber may include a dielectric core wall defining a hollow space. The optical fiber may also include a cladding layer surrounding the dielectric core wall and spaced apart from the dielectric core wall. The optical fiber may further include a plurality of supports extending from the cladding layer to the dielectric core wall. A thickness of the dielectric core wall may be greater than a thickness of each of the plurality of supports. The dielectric core wall may be configured to carry an optical light for sensing the analyte.

A two-piece optical prism includes a prism having a groove and prism having arc faces, where the prism having a groove has at least one first arc face and groove having at least one second arc face, and the prism having arc faces is placed in the groove of the prism having a groove and has at least one third arc face. The present invention can be used in the surface plasmon resonance optical system for the angle, range adjustment and control of incident light (e.g. laser light), capable of constituting an optical wide-angle, multi-angle incident system to carry out the wide-angle, multi-angle scanning detection of surface plasmon resonance, increasing the system dynamic detection range and sensitivity; and further reducing a detection chip.

The present invention includes a prism having a light incidence surface and a film formation surface, a metal film disposed on the film formation surface, and a trapping body secured to the metal film. Excitation light is irradiated from an excitation light irradiation part onto an analysis chip installed in a chip holder, and excitation light reflected by the analysis chip is detected. The information outputted by the excitation light irradiation part is acquired.

The invention relates generally to systems and methods for assaying a biological sample suspected of comprising a target biomolecule using cascading amplification.

Provided herein are methods of assessing or validating a cleaning procedure of a biotherapeutic manufacturing process, said method comprising analyzing by a surface plasmon resonance (SPR)-based assay the binding activity of a cleaned sample to a ligand which binds to a biotherapeutic produced by the manufacturing process. In various embodiments, the cleaning procedure comprises one or more steps to inactivate and/or degrade the biotherapeutic. In various instances, the method demonstrates that greater than about 99.99% degradation of the therapeutic is achieved by the cleaning procedure comprising the one or more steps to inactivate and/or degrade the biotherapeutic.

The invention relates to a sensor module (1) for multiparametric analysis of a medium (105) and to the uses thereof. The sensor module (1) according to the invention is characterised by a combination of photonic and non-photonic measurement principles with parameter-sensitive coatings (103) on a substrate (100). A plurality of properties of a medium (105) can be detected over wide parameter ranges, wherein the most suitable method can be used for the corresponding parameter, at least for example with regard to the accuracy, the long-term stability, the resolution, the reproducibility, the energy consumption, the manufacturing costs, the necessary space requirements.