A measurement mechanism that has a body, a vacuum chamber located on the body and in which a measurement process is performed is disclosed. A first sample and a second sample between which a heat transfer occurs are placed in the vacuum chamber and contact each other. A piston that provides the first sample and the second sample to continuously contact each other, a measurement unit that contacts the first sample and the second sample, and a cooler located below the first sample and the second sample is also disclosed.

The present disclosure relates generally to thermal analyses having direct application of thermal energy to a sample.

A sensing and analysis system on a chip for sensing and analyzing chemical or biological analytes includes a chromatography column having an inlet and an outlet formed on the chip for temporal separation of components of analytes and at least one whispering gallery mode (WGM) optical resonator for sensing of the components. The chromatography column is formed on a first wafer layer. Each WGM optical resonator includes a hollow sealed enclosure formed at or over the inlet or the outlet of or elsewhere along the chromatography column such that a gas flowing through the chromatography column fills the hollow sealed enclosure. Each WGM optical resonator further includes an optical waveguide aligned with the sealed hollow enclosure for evanescent wave light coupling.

Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

The present disclosure provides devices and methods for diagnosing, monitoring the disease progression of, and/or evaluating the risk for developing a disease by detecting thermostable variants of proteins and/or metabolites in biological samples using differential scanning calorimetry. Also disclosed herein are methods for monitoring the efficacy of a particular therapeutic regimen in patients in need thereof.

A measuring arrangement and method for a thermal analysis of a sample, having a crucible for storing a sample in the crucible, as well as a sensor for measuring a sample temperature of the sample when the crucible is arranged on the sensor. To provide for a high level of reproducibility of measurements in the case of such a measuring arrangement and a method for the thermal analysis performed with the measuring arrangement, the measuring arrangement has an anti-rotation protection for the crucible, in order to provide a predetermined rotational position of the crucible with respect to the sensor when the crucible is arranged on the sensor. The invention includes a method for the thermal analysis of a sample, which is performed using such a measuring arrangement.

A measuring arrangement for a thermal analysis of a sample, having a crucible for storing a sample in the crucible, as well as a sensor for measuring a sample temperature of the sample when the crucible is arranged on the sensor. To reduce the risk of damages to or even the destruction of used components as a result of chemical or physical reactions, it is provided according to the invention that the measuring arrangement further has a washer arrangement, which is inserted between the crucible and the sensor and which has a first layer, which contacts the crucible, of a first material and a second layer, which contacts the sensor, of a second material, which differs from the first material. The invention further proses a method for the thermal analysis of a sample, which is performed by using such a measuring arrangement.

An apparatus is provided for sensing an analyte in a fluid. The apparatus includes a fluid collecting device configured to collect the fluid containing the analyte; a fluid input in fluid communication with the fluid collecting device configured to input the fluid containing the analyte into the fluid collecting device, an analyte interactant in fluid communication with the fluid collecting device, wherein the analyte interactant, when contacted by the analyte, reacts to cause a first change in thermal energy within the fluid collecting device; a modulator that causes a second change in thermal energy; a thermal sensing device comprising at least one pyroelectric device thermally coupled to the fluid collecting device to generate a first signal in response to at least one of the first change in thermal energy and the second change in thermal energy; a control device operatively coupled to the thermal sensing device and the modulator that generates a second signal, wherein the second signal comprises information useful in characterizing the analyte. A related method also is disclosed.

Provided are a method and a device for acquiring a temperature and a computer-readable storage medium. The method for acquiring a temperature includes: building a temperature acquisition model, wherein the temperature acquisition model is configured to acquire, based on an operating parameter of the radioactive substance treatment system input to the temperature acquisition model, a temperature of different parts of the radioactive reactant in the radioactive substance treatment system under a condition of the parameter; inputting a current operating parameter of the radioactive substance treatment system into the temperature acquisition model during the treatment for the radioactive substance; and acquiring a current temperature of different parts of the radioactive reactant in the radioactive substance treatment system output by the temperature acquisition model.

A measuring device, in particular a calorimeter, is described which comprises: i) a sensor device which is configured for capturing a measurand with respect to a sample and which comprises: ia) a base region, and ib) a sample storing region which protrudes from a main surface of the base region and which is configured for storing a sample reception; ii) a sensor interior in which the sensor device is at least partially arranged; iii) a rinsing gas supply device which is configured for providing a rinsing gas into the sensor interior; and iv) a gas-conducting element which covers the sensor interior and which comprises: at least one opening through which the protruding sample storing region at least partially extends, such that a slit between a side wall of the protruding sample storing region and the gas-conducting element remains.