A semiconductor structure capable of real-time spatial sensing of nanoparticles within a nanofluid is provided. The structure includes an array of gate structures. An interlevel dielectric material surrounds the array of gate structures. A vertical inlet channel is located within a portion of the interlevel dielectric material and on one side of the array of gate structures. A vertical outlet channel is located within another portion of the interlevel dielectric material and on another side of the array of gate structures. A horizontal channel that functions as a back gate is in fluid communication with the vertical inlet and outlet channels, and is located beneath the array of gate structures. A back gate dielectric material portion lines exposed surfaces within the vertical inlet channel, the vertical outlet channel and the horizontal channel.

Cell monitoring apparatus includes sensing chip and channel module. Sensing chip includes channel region, source and drain regions, and sensing film. The channel region includes first semiconductor material. The source and drain regions are disposed at opposite sides of the channel region, and include a second semiconductor material. Sensing film is disposed on the channel region at a sensing surface of the sensing chip. Channel module is disposed on the sensing surface of sensing chip. A microfluidic channel is formed between the sensing surface of the sensing chip and a proximal surface of the channel module. The microfluidic channel includes a culture chamber and a micro-well. The culture chamber is concave into the proximal surface of the channel module, and overlies the channel region. The micro-well is concave into a side of the culture chamber, and directly faces the sensing film.

Provided are devices and methods to detect the presence of volatile organic compounds related to the presence of a disease state in a biological sample. The devices may include a detection moiety such as a polynucleotide in electronic communication with a semiconductor such as graphene or a carbon nanotube.

Dual-gate ion-sensitive field effect transistors (ISFETs) for disease diagnostics are disclosed herein. An exemplary dual-gate ISFET includes a gate structure and a fluidic gate structure disposed over opposite surfaces of a device substrate. The gate structure is disposed over a channel region defined between a source region and a drain region in the device substrate. The fluidic gate structure includes a sensing well that is disposed over the channel region. The sensing well includes a sensing layer and an electrolyte solution. The electrolyte solution includes a constituent that can react with a product of an enzymatic reaction that occurs when an enzyme-modified detection mechanism detects an analyte. The sensing layer can react with a first ion generated from the enzymatic reaction and a second ion generated from a reaction between the product of the enzymatic reaction and the constituent, such that the dual-gate ISFET generates an enhanced electrical signal.

A chemical sensor module includes first to n-th (n is a natural number of 2 or greater) graphene sensors; and an exposure mechanism exposing the first to n-th graphene sensors to first to n-th aqueous solutions containing a sample substance and having different concentrations of phosphate ion, magnesium ion, or sulfate ion. The chemical sensor module identifies the sample substance from the difference in electrical characteristics of the first to n-th graphene sensors.

This invention is about a product of a flip chip thin film hybrid screen printed electrode. It combines a primary screen printed electrode (SPE) device and a thin film material coated chip, in order to make a hybridized product. The product is used as a test strip for electrochemical analysis, such as environmental, bio-electrochemical and biomedical sensors. The hybridized electrodes design takes the benefits of low cost of screen printing technology, and high sensitivity of thin film coating nanotechnology. This invention is also about applying a flip chip method to manufacture the hybrid electrode. A chip of thin film material coated solid state substrate is surface mounted to a preliminary perforated SPE by a flip chip method/process. This method/process is fast, easy, cheap, uniform, and suitable for large scale manufacturing.

A method for making a hydrophobic biosensing device includes forming alternating layers over a top and sides of a fin on a dielectric layer to form a stack of layers. The stack of layers are planarized to expose the top of the fin. The fin and every other layer are removed to form a cathode group of fins and an anode group of fins. A hydrophobic surface on the two groups of fins.

Provided is a semiconductor-based ion-responsive urine sensor (IRUS) capable of detecting an analyte in urine by a non-invasive method. When a urine sensor according to an aspect is used, it is possible to diagnose a patient accurately in a comfortable condition and to use the urine sensor for point-of-care (POC) diagnosis.

Techniques for increasing the lifespan of a nanopore DNA sensing device are disclosed. A related method may include forming a first electrode, forming a second electrode, disposing the first electrode and second electrode within an insulator, and disposing a lipid bilayer having a nanopore between the first electrode and second electrode. The forming of the second electrode may comprise forming a silver (Ag) layer, pressing a mold into the Ag layer to form a pattern in the Ag layer, removing the mold from the Ag layer, and exposing the Ag layer to an electrolyte.

The claimed invention is directed to a finFET biosensor with improved sensitivity and selectivity. Embodiments of the invention are also directed to finFET biosensor arrays, methods for operating finFET biosensors with improved sensitivity and selectivity, and methods of operating finFET biosensor arrays.