A nanobio-sensing device includes: a substrate; a source electrode and a drain electrode which are disposed on the substrate and spaced apart from each other; a sensing film which serves as a channel connecting the source electrode and the drain electrode and is in contact with at least a part of the source electrode and the drain electrode; a first gate electrode which is a floating gate, extends while one end of the first gate electrode is in contact with a part of the sensing film, and is capable of being in contact with a part of the source electrode and/or the drain electrode; and a second gate electrode which is in contact with the other end of the first gate electrode to form a first gate stacked structure.

The present invention is related to engineered nucleic acid bases for use in molecular electronics, such as nanosensors, molecular-scale transistors, FET devices, molecular motors, logic and memory devices, and nanogap electronic measuring devices for the identification and/or sequencing of biopolymers.

A method for detecting a species of bacteria in a sample solution. The method includes putting the sample solution in contact with an array of zinc oxide nanorods on a gate region of a field effect transistor (FET) biosensor, applying an alternating current (AC) voltage between source and drain electrodes of the FET biosensor, applying a first direct current (DC) voltage of V.sub.1 to the sample solution, measuring a first set of electrical impedance values (Z.sub.1) between the source region and the drain region, calculating a first impedance difference set (ΔZ.sub.1) between the Z.sub.1 and a respective first initial set of electrical impedance values (Z.sub.1.sup.0) associated with a bacteria-free reference solution, determining bacteria indicative factors including a first impedance difference peak value (ΔZ.sub.1m) and a respective peak frequency (f.sub.m), and detecting a presence of a first species of bacteria in the sample solution based on the bacteria indicative factors.

A carbon nanotube sensor device for detecting CO.sub.2 and methods of its production and use. A printable polyethylenimine (PEI)-functionalized carbon nanomaterial paste may be used to form the active sensing layer of the device, which is particularly sensitive to CO.sub.2. A separate printed heating layer may be used to maintain the working temperature of the sensor, as well as to remove and/or clear volatile gases from the sensor.

A gas sensor has a sensing structure that is used for generating, for a variety of gases, multiple corresponding electric signals. It has a plurality of measuring electrodes and a gas-sensitive film coating the measuring electrodes; and a micro-heating structure that is used for providing different heating temperatures for the sensing structure, and a silicon-based substrate and a heating layer disposed on the silicon-based substrate. The heating layer integrates heating electrodes of different sizes or different layouts to form a plurality of heating regions of different temperatures, and the plurality of measuring electrodes are respectively disposed in the corresponding heating regions. By integrating heating electrodes of different sizes or different layouts on a single micro-heating structure to form heating regions of different temperatures, a complex atmosphere detection function of a variety of sensing materials at different temperatures is achieved.

Disclosed are sensors that include a carbon nanotube channel and a non-fouling polymer layer, where the non-fouling polymer layer and the carbon nanotube channel do not directly contact each other and are separated by a dielectric layer. The disclosed sensors may be used, e.g., as biosensors for the accurate and sensitive detection of analytes within a sample. Also disclosed are methods of making and using the sensors.

Devices for sequencing biopolymers and methods of using the devices are disclosed. In one example, such a device has a nanopore, a plurality of wells and fluidic tunnels to allow a biopolymer to translocate in the device. In some embodiments, the device may include integrated electronics or micro-electromechanical systems, such as valves, bubble generators/annihilators or pressure pulse generators, to actively control fluidic/ionic/electric flows in the device.

A reinforced thin-film device (100, 200, 500) including a substrate (101) having a top surface for supporting an epilayer; a mask layer (103) patterned with a plurality of nanosize cavities (102, 102′) disposed on said substrate (101) to form a needle pad; a thin-film (105) of lattice-mismatched semiconductor disposed on said mask layer (103), wherein said thin-film (105) comprises a plurality of in parallel spaced semiconductor needles (104, 204) of said lattice-mismatched semiconductor embedded in said thin-film (105), wherein said plurality of semiconductor needles (104, 204) are substantially vertically disposed in the axial direction toward said substrate (101) in said plurality of nanosize cavities (102, 102′) of said mask layer (103), and where a lattice-mismatched semiconductor epilayer (106) is provided on said thin-film supported thereby.

An apparatus includes a biosensor integrated circuit (IC) chip with sensing zones and/or well structures configured to receive a liquid with biological analytes. The chip includes passivation and etch stop layers with an opening over a channel layer and an array of liquid gated field effect transistors with a 2D channel disposed on a dielectric oxide layer. A conductive drain and a conductive source form edge and/or top side contacts with opposite ends of the 2D channel. The chip further includes reference electrodes formed in a metal layer, configured to contact the liquid, and disposed at a horizontal distance apart from the graphene channels. The transistors are operable to enable a set of measurements to sense parameters of the biological analytes based on changes in a shape of Id-Vgs transconductance curves. A system and a method have similar structures and perform the functions of the apparatus.

In various embodiments of the present disclosure, a molecular electronics sensor array chip comprises: (a) an integrated circuit semiconductor chip; and (b) a plurality of molecular electronic sensor devices disposed thereon, each of said sensor devices comprising: (i) a pair of nanoscale source and drain electrodes separated by a nanogap; (ii) a gate electrode; and (iii) a bridge and/or probe molecule spanning the nanogap and connecting the source and drain electrodes, wherein the molecular electronic sensor devices are organized into an electronically addressable, controllable, and readable array of sensor pixels.