When injecting a sample into carrier-liquid channels (3A and 3B), injection shock is prevented. Septa 13 and 14 constitute the upper wall and the lower wall of a sample injection part (11) of the carrier-liquid channels (3A and 3B). A needle (27) can vertically penetrate the septum (13) on the upper wall side and also penetrate the septum (14) on the lower wall side. A needle moving unit (28) induces the needle (27) to penetrate the septum (14) on the lower wall side and induces the tip of the needle to face the inside of a sample vessel (26). A measurement pump (29) is operated for drawing and as a result a sample is drawn into the needle (27). Next, the needle (27) is extracted from the septum (14) on the lower wall side, the tip of the needle is induced to face the inside of the sample injection part (11), the measurement pump (29) is caused to discharge and as a result the sample within the needle (27) is injected.

A fractionating liquid chromatograph (1) includes a liquid delivery pump (200), a sampler (300) connected to the liquid delivery pump (200), a separation column (400) connected to the sampler (300), and a detector (500) connected to the separation column (400) and the sampler. The sampler (300) includes a needle that suctions or discharges a sample, and a flow path switching valve connected to the needle. The fractionating liquid chromatograph (1) further includes a controller (100) that sets a state of the flow path switching valve to a first state and a second state, the first state being a state in which the needle is connected to a storage unit for storing the sample, the second state being a state in which the needle is connected to the detector.

A fractionating liquid chromatograph (1) includes a liquid delivery pump (200), a sampler (300) connected to the liquid delivery pump (200), a separation column (400) connected to the sampler (300), and a detector (500) connected to the separation column (400) and the sampler. The sampler (300) includes a needle that suctions or discharges a sample, and a flow path switching valve connected to the needle. The fractionating liquid chromatograph (1) further includes a controller (100) that sets a state of the flow path switching valve to a first state and a second state, the first state being a state in which the needle is connected to a storage unit for storing the sample, the second state being a state in which the needle is connected to the detector.

A configurable injector for injecting a fluidic sample in a separation path of a sample separation apparatus includes a sample accommodation volume for accommodating the fluidic sample to be injected into the separation path, a valve arrangement fluidically couplable with the separation path, fluidically coupled with the sample accommodation volume, and being controllable for injecting the fluidic sample into the separation path, an input interface configured for receiving input data indicative of an injection profile of an injector to be emulated by the configurable injector, and a control unit configured for controlling the configurable injector, in particular the valve arrangement, so that the configurable injector is operated in accordance with the injection profile to thereby emulate the injector to be emulated.

A configurable injector for injecting a fluidic sample in a separation path of a sample separation apparatus includes a sample accommodation volume for accommodating the fluidic sample to be injected into the separation path, a valve arrangement fluidically couplable with the separation path, fluidically coupled with the sample accommodation volume, and being controllable for injecting the fluidic sample into the separation path, an input interface configured for receiving input data indicative of an injection profile of an injector to be emulated by the configurable injector, and a control unit configured for controlling the configurable injector, in particular the valve arrangement, so that the configurable injector is operated in accordance with the injection profile to thereby emulate the injector to be emulated.

The invention relates to a method for feeding a sample into an analysis branch of a liquid chromatography system, in particular a high-performance liquid chromatography system. A solvent or a solvent mixture from at least one solvent branch is supplied as volume flow {dot over (A)} into the analysis branch. At least one sample from at least one sample branch is fed as volume flow into the analysis branch within a predetermined time interval. The volume flow {dot over (A)} is reduced to an extent during the predetermined time interval, and a volume flow resulting from the sum of the volume flows {dot over (A)} and remains substantially constant in the analysis branch. The invention further relates to a sampler for carrying out a method of this kind.

The invention relates to a method for feeding a sample into an analysis branch of a liquid chromatography system, in particular a high-performance liquid chromatography system. A solvent or a solvent mixture from at least one solvent branch is supplied as volume flow {dot over (A)} into the analysis branch. At least one sample from at least one sample branch is fed as volume flow into the analysis branch within a predetermined time interval. The volume flow {dot over (A)} is reduced to an extent during the predetermined time interval, and a volume flow resulting from the sum of the volume flows {dot over (A)} and remains substantially constant in the analysis branch. The invention further relates to a sampler for carrying out a method of this kind.

Provided is a mechanism for connecting columns and needles, including: a base member 60 on which needles 61a and 61b with their tips directed upward are provided; and a column rack 10 having column holders for holding columns 10a and 10b in an upright position while allowing all upward shift of the columns, with an opening provided below each column holder. With the needles 61a and 61b positioned directly below the openings, the base member 60 is elevated until its upper surface comes in contact with the bottom of the column rack 10, whereby the needles 61a and 61b are inserted through the openings into the columns 20a and 20b. When the base member 60 is in contact with the column rack 10, the columns 20a and 20b are pushed by the needles 61a and 61b to a higher position within the column rack 10 than their original position.

Provided is a mechanism for connecting columns and needles, including: a base member 60 on which needles 61a and 61b with their tips directed upward are provided; and a column rack 10 having column holders for holding columns 10a and 10b in an upright position while allowing all upward shift of the columns, with an opening provided below each column holder. With the needles 61a and 61b positioned directly below the openings, the base member 60 is elevated until its upper surface comes in contact with the bottom of the column rack 10, whereby the needles 61a and 61b are inserted through the openings into the columns 20a and 20b. When the base member 60 is in contact with the column rack 10, the columns 20a and 20b are pushed by the needles 61a and 61b to a higher position within the column rack 10 than their original position.

The present invention discloses a general sample injector, comprising a sample injection port mechanism, a sample injector shell, a vaporizing chamber, a heater, a temperature control unit, a carrier gas channel, a septum purge channel, a flow splitting channel, a coolant channel, a multichannel flow control valve and a temperature control unit. The general sample injector, equivalent to a programmed temperature vaporizer injector combining splitting/no splitting with cold column head sample injection, gives full play to the advantages of various sample injection modes, overcomes a plurality of disadvantages, and has higher practicability and better flexibility.