Disclosed are a mutually independent dual online liquid chromatography device and a control method thereof. The mutually independent dual online liquid chromatography device according to the present disclosure includes a first pump configured to inject a first solvent or a mixed solution containing the first solvent and a second solvent; a second pump configured to inject the first solvent or the mixed solution containing the first solvent and the second solvent; a sample inlet valve to which the first pump and a sample injector configured to inject a sample are connected; a first column valve to which a first sample separation column is connected; a second column valve to which a second sample separation column is connected; and a column selection valve to which the second pump is connected, and interposed between the sample inlet valve, and the first column valve and the second column valve to inject the sample fed from the sample inlet valve onto any one of the first sample separation column and the second sample separation column to separate and analyze the sample in one sample separation column while allowing for wash and equilibration, sample injection and isocratic elution of the other sample separation column.

Disclosed are a mutually independent dual online liquid chromatography device and a control method thereof. The mutually independent dual online liquid chromatography device according to the present disclosure includes a first pump configured to inject a first solvent or a mixed solution containing the first solvent and a second solvent; a second pump configured to inject the first solvent or the mixed solution containing the first solvent and the second solvent; a sample inlet valve to which the first pump and a sample injector configured to inject a sample are connected; a first column valve to which a first sample separation column is connected; a second column valve to which a second sample separation column is connected; and a column selection valve to which the second pump is connected, and interposed between the sample inlet valve, and the first column valve and the second column valve to inject the sample fed from the sample inlet valve onto any one of the first sample separation column and the second sample separation column to separate and analyze the sample in one sample separation column while allowing for wash and equilibration, sample injection and isocratic elution of the other sample separation column.

A field flow fractionator (FFF device) 1 classifies particles in a liquid sample by applying a field to a liquid sample supplied from a sample injection device 5. A detector 6 detects the particles in the liquid sample classified by the FFF device 1. A bypass flow path 8 supplies the liquid sample from the sample injection device 5 to the detector 6 without via the FFF device 1. A rotary valve (flow path switching unit) 4 switches a flow path to guide the liquid sample from the sample injection device 5 to the FFF device 1 or a bypass flow path 8. The bypass flow path 8 is provided with a concentration adjusting device 9 for adjusting the concentration of the liquid sample from the sample injection device 5. In a case where a sample with the same quantity as the sample supplied to the FFF device 1 is supplied to the bypass flow path 8 at the time of analysis, the sample is diluted by the concentration adjusting device 9 such that a detection signal from the detector 6 falls within a dynamic range.

A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

Injector (40) for injecting a fluidic sample into a mobile phase in a sample separation apparatus (10), the injector (40) comprising a main flow path (100) between a fluid drive (20) and a sample separation device (30), wherein the fluid drive (20) is adapted to drive the mobile phase and the sample separation device (30) is adapted to separate the fluidic sample that is injected into the mobile phase, a discharge device (104) for discharging an, in particular predetermined, amount of the mobile phase from the main flow path (100), and a supply device (102) for supplying an, in particular predetermined, amount of the fluidic sample and/or of a solvent into the main flow path (100), wherein the discharged amount and the supplied amount compensate each other at least partially.

Injector (40) for injecting a fluidic sample into a mobile phase in a sample separation apparatus (10), the injector (40) comprising a main flow path (100) between a fluid drive (20) and a sample separation device (30), wherein the fluid drive (20) is adapted to drive the mobile phase and the sample separation device (30) is adapted to separate the fluidic sample that is injected into the mobile phase, a discharge device (104) for discharging an, in particular predetermined, amount of the mobile phase from the main flow path (100), and a supply device (102) for supplying an, in particular predetermined, amount of the fluidic sample and/or of a solvent into the main flow path (100), wherein the discharged amount and the supplied amount compensate each other at least partially.

A gas sampler includes a connection portion connectable to an introduction piping connected to a sample tank, a switching valve for switching a connection state between the connection portion and a sample loop, a pump, and a control device. A buffer flow path between the sample loop and the pump is configured to be selectively connectable to any one of a plurality of buffer tanks different in volume. A volume of the buffer flow path is greater than a volume of the introduction piping by a predetermined amount. The control device operates the pump in a state in which the switching valve is in a closed state to set an inside of the buffer flow path to a negative pressure, and thereafter stops the pump and make the switching valve in an open state to fill the sample loop with a sample gas by using the negative pressure of the buffer flow path.

A gas sampler includes a connection portion connectable to an introduction piping connected to a sample tank, a switching valve for switching a connection state between the connection portion and a sample loop, a pump, and a control device. A buffer flow path between the sample loop and the pump is configured to be selectively connectable to any one of a plurality of buffer tanks different in volume. A volume of the buffer flow path is greater than a volume of the introduction piping by a predetermined amount. The control device operates the pump in a state in which the switching valve is in a closed state to set an inside of the buffer flow path to a negative pressure, and thereafter stops the pump and make the switching valve in an open state to fill the sample loop with a sample gas by using the negative pressure of the buffer flow path.

A diaphragm valve for gas analysis applications is provided. The valve includes a valve cap provided with a plurality of process conduits extending therethrough, a valve body engageable with the valve cap and having a body interface provided with a recess, a diaphragm positioned between the valve cap and valve body and having a process groove for circulating fluid therein, the process groove engaging the recess, a plunger assembly provided within the valve body, the plunger assembly comprising a plurality of plungers movable between a closed position wherein the plunger engages the diaphragm, and an open position wherein the plunger is spaced from the diaphragm, and an actuating assembly comprising a gas inlet to allow the injection of actuating gas therein, the actuating assembly comprising a purging system for purging a region located between the diaphragm and the body interface, whereby the actuating gas is used for purging the region.