A sorbent tube apparatus (10) for high-pressure fluid sample analysis, the sorbent tube apparatus (10) comprising a pressurisable housing (32) having first and second fluid ports (48a, 48b) and defining a fluid chamber (34) therein; and a sorbent tube (12) mountable within the pressurisable housing (32), the sorbent tube (12) extending from one of the first and second fluid ports (48a) and spaced apart from the other of the first and second fluid ports (48b) to be in fluid communication with the fluid chamber (34), thereby enabling in use pressure equalisation between the sorbent tube (12) and fluid chamber (34). A method of analysing high-pressure fluid, an analytic probe apparatus, a further sorbent tube apparatus and method of preventing or limiting damage to a sorbent tube during high-pressure fluid sampling are also provided.

Provided herein in some embodiments is a column including a housing assembly and a cartridge assembly. The housing assembly can include a housing top, a housing bottom, and a housing siding. The housing siding can be fixedly coupled to the housing top and the housing bottom forming hermetic seals therebetween. The cartridge assembly can include a cartridge top, an outer frit, and an inner frit disposed within the outer frit. A toroidal space can defined by the cartridge top, the outer frit, the inner frit, and the housing bottom. The toroidal space can be configured to hold a stationary phase for radial flow column chromatography. Also provided herein in some embodiments is a process including assembling the cartridge assembly, assembling the housing assembly about the cartridge assembly, and pressure testing the column. In some embodiments, the process can further include charging the toroidal space with a stationary phase.

A planar separation component for gas chromatograph includes a substrate made of aluminum, a porous anodic aluminum oxide separation member, and a cover unit. The substrate has a planar body, and a first flow channel having a first inlet and a first outlet. The separation member is formed on the substrate, and has a channel-defining wall defining the first flow channel and a plurality of nanosized pores in spatial communication with the first flow channel. The cover unit is bonded to the planar body for covering the first flow channel. Methods for manufacturing the planar separation component and separating a mixture containing compounds different in boiling point using the planar separation component are also disclosed.

A gas chromatographic (GC) unit or module may include one or more microfluidic devices, a GC column, and a flow controller (FC) comprising an FC input port for controlling fluid flows and pressures. The GC unit may be reconfigurable to provide different functionalities. The GC unit may be fluidly coupled to various other fluidic devices, such as other GC units, sample inlets, GC detectors, and the like. Multiple GC units and other fluidic devices may be utilized to build GC devices and associated systems of flexible, reconfigurable, and scalable architecture, thereby enabling a variety of modes of operation useful for present and future GC method development.

A method for packing a chromatography column with chromatography media, comprising the steps of: providing a system comprising a column tube having a closed first end comprising an inlet/outlet, a media inlet adjacent a second end of the column tube and an adaptor positioned inside the column tube initially adjacent the second end of the column tube for sliding and sealing contact with an inner face of the column tube, the column tube and adaptor arranged initially such that they define an internal volume and such that the media inlet is in fluid connection with the internal volume; connecting a media slurry source to the media inlet; at least partially filling the internal volume with media slurry via the media inlet; forcing the adaptor towards the first end of the column tube to reduce the internal volume such that the media inlet is no longer in fluid connection with the reduced internal volume.

The invention relates to a method for providing an aseptic chromatography column, said method comprising the steps of: pre-sterilize an empty chromatography column; pre-sterilize a chromatography medium; introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thereby providing an aseptic chromatography column comprising chromatography medium.

The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

The invention relates to a system for packing chromatography columns with a chromatography medium and packing method for use in such columns. In particular, the invention relates to a method and system for packing chromatography columns where the column and chromatography media are pre-sterilized.

A method for providing an aseptic chromatography column includes the steps of pre-sterilizing an empty chromatography column, pre-sterilizing a chromatography medium, introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thus providing an aseptic chromatography column comprising chromatography medium.

A thermal conductivity detector includes: a first flow path (4) in which a filament (2) is arranged; a second flow path (6) provided separately from the first flow path (4); an introduction flow path (8) configured to fluidly communicate between an upstream of the first flow path (4) and an upstream end of the second flow path (6); a sample inlet (10) configured to introduce a sample gas to the introduction flow path (8); a first gas inlet (12) provided between the sample inlet (10) in the introduction flow path (8) and an upstream end of the first flow path (4); a second gas inlet (14) provided between the sample inlet (10) in the introduction flow path (8) and an upstream end of the second flow path (6); a carrier gas supply source (18); a selector (22) configured to selectively introduce the carrier gas from the carrier gas supply source (18) to one of the first gas inlet (12) and the second gas inlet (14); and a detection circuit (24) configured to detect a component in a sample gas via the filament (2), wherein when the carrier gas from the carrier gas supply source (18) is guided to the first gas inlet (12), a reference phase in which only the carrier gas flows through the first flow path (4) is formed, when the carrier gas from the carrier gas supply source (18) is guided to the second gas inlet (14), a sampling phase in which the sample gas flows through the first flow path (4) is formed, and wherein fluid resistance of the first flow path (4) and flow resistance of the second flow path (6) are designed such that a ratio of a difference between a reference flow rate and a sampling flow rate to each of the reference flow rate and the sampling flow rate becomes 15% or less, the reference flow rate being a flow rate of a gas flowing through the first flow path (4) in the reference phase, the sampling flow rate being a flow rate of gases flowing through the first flow path (4) in the sampling phase.