The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

A sample analysis method includes directing a sample that contains one or more SVOC components to a GC column to temporally separate components present in the sample. Output gas from the GC column is expanded into a sample cell. The sample cell is held at a temperature and pressure that are lower than the temperature and pressure at an outlet of the GC column. The volume of the sample cell is sufficiently large for maintaining the one or more SVOC components in a gaseous phase. Infrared spectra of the components in the sample cell are obtained using a Fourier transform infrared spectrometry system.

A thermal desorption tube collection system uses a thermoelectric cooler to collect and concentrate gas samples. In some modes, the operation of the cooler is reversed to flow the concentrated sample directly into a separator such as a gas chromatography system. Components resolved in time by a thermal desorption separator accumulate in a sample cell and are analyzed by electromagnetic radiation-based spectroscopic techniques. Also presented are methods for analyzing biogas samples.

A system and method are disclosed for analyzing samples, which includes a spectrometry system for detecting components of a sample; a gas chromatography column for separating the components of a sample; a first sample unit for receiving a first sample from a sample source; and a second sample unit for receiving a second sample from a sample source. Each sample loop unit allows independent processing of samples in preparation for analysis.

Components resolved in time by a thermal desorption separator accumulate in a sample cell and are analyzed by electromagnetic radiation-based spectroscopic techniques.

Synthetic Cannabinoids are the most complex branch of designer drugs encountered in forensic chemistry. A screening method has been developed that can accurately identify the correct structural category of an unknown Synthetic Cannabinoid. Knowledge of this information is very important when no reference data or standards are available since certain sub-categories contain Schedule I Controlled Dangerous Substances. The Bridge portion of these molecules present a unique carbonyl band cluster within a small 200 wavenumber interval of the mid-infrared region that can only exist in vapor phase through GC/FTIR light-pipe technology or heated static vapor cell FTIR. This special relationship is not applicable to any other forms of solid phase vibrational spectroscopy (FTIR, RAMAN) including GC/FTIR solid-deposit techniques. The carbonyl frequency from the Bridge is used as the first step in the screening process which separates the entire forensically encountered class of Synthetic Cannabinoids into 35 sub-categories. Additional bands within the cluster from secondary functional groups, rotational isomerism, and fermi resonance add further refinement within these categories.

A method and system for detecting siloxanes using thermal desorption tubes and FTIR spectrometers with intervening gas chromatography systems.

A method and system for sample analysis involve a temporally-resolving separation of sample components. In the method, solvent vapors are condensed prior to entering a temporally-resolving separator, a GC column, for example, and solvent-depleted vapors are directed to the separator where constituents are resolved in time. A system for analyzing a sample comprises an injection port, a temporally-resolving separator (e.g., a GC column) and a conduit connecting the two. The injection port is at a temperature sufficiently high to vaporize the solvent and analytes present in a sample. The conduit is configured and/or operated to condense the solvent, while maintaining the analytes in the vapor phase.

Components resolved in time by a separator accumulate in a sample cell and are analyzed by electromagnetic radiation-based spectroscopic techniques. The sample cell can be configured for multiple path absorption and can be heated. The separator can be a gas chromatograph or another suitable device, for example a distillation-based separator. The method and system described herein can include other mechanical elements, controls, procedures for handling background and sample data, protocols for species identification and/or quantification, automation, computer interfaces, algorithms, software or other features.

Disclosed in the present invention is a system and method for supplying acetylene to an apparatus using acetylene, the system having at least one acetylene storage apparatus and an acetylene content analysis apparatus. The system and method disclosed in the present invention can utilize the capacity of an acetylene cylinder to a higher degree; before the solvent impurity concentration in acetylene gas reaches a level where it is no longer suitable, a more accurate understanding of the usable acetylene amount in the acetylene storage apparatus can be gained through detection, thereby reducing the number of times that the acetylene storage apparatus is refilled and replaced, and lowering the user's total costs.