This disclosure relates to hyperpolarized probes for use in magnetic resonance studies of biological systems.

A medical testing system comprises a housing, at least one magnet assembly configured around a probe configured to accept a human finger, formed in the housing wherein the at least one magnet assembly creates a permanent magnetic field around the probe, an RF signal generator configured to create a temporary magnetic field perpendicular to the permanent magnetic field in the housing, and an NMR coil assembly wherein a change in the permanent magnetic field induces a voltage in the NMR coil assembly.

There is provided a Nuclear Magnetic Resonance (NMR) measurement cell for use with a solution enabling the introduction of a gas into said solution. The measurement cell includes at least a detection volume designed to be installed in a static magnetic field of an NMR spectrometer, and includes in said detection volume, a gas introduction zone, a measurement chamber for the solution at a distance from the gas introduction zone and a network of conduits for the solution formed to set up fluid communication between the gas introduction zone and the measurement chamber. The gas introduction zone includes at least one gas inlet in the network of conduits, to generate bubbles in the gas introduction zone only. There is also provided a method of manufacturing such a measurement cell and a measurement assembly including such a measurement cell.

In one aspect, the disclosure relates to a nuclear magnetic resonance transceiver including: (a) a variable-frequency electromagnetic signal generator with (i) a frequency input and (ii) an EM signal output; (b) an electronic frequency controller including (i) a frequency output coupled to the frequency input of the variable-frequency EM signal generator, (ii) an intermediate frequency set-point input, and (iii) an intermediate frequency measurement input; (c) an NMR transmission probe with an EM signal input coupled to the EM signal output of the variable-frequency EM signal generator; (d) an NMR receiving probe with an EM signal output; and (e) an electronic mixer with (i) a first input coupled to the EM signal output of the NMR receiving probe, (ii) a second input coupled to the EM signal output of the variable-frequency EM signal generator, and (iii) a mixed EM signal output coupled to the frequency measurement input of the frequency controller.

A method and microfluidic device to perform reservoir simulations using pressure-volume-temperature (PVT) analysis of wellbore fluids.

Systems and methods are provided for producing hyperpolarized materials for use during a magnetic resonance imaging (MRI) or nuclear magnetic resonance (NMR) process. The system and methods include the use of microfluidic and/or microreactor methods in one or more of the stages of parahydrogen production, enriched substrate production, and spin order transfer from the parahydrogen to a substrate.

A method and apparatus for polarizing nuclear or electronic spins is disclosed. An analyte is passed near a surface that has a plurality of spin defect centers implanted within 10 nm of the surface. The spin defect centers are exposed to a magnetic field and illumination to produce polarized spins. The polarized spins then induce spin polarization in the analyte.

The disclosure relates to a system and a method of analysing a physiological condition in an analyte. In particular, the disclosure pertains to systems, components of such systems, and methods of analysing a physiological condition in an analyte using hyperpolarization (HP) and magnetic resonance (MR) techniques.

An NMR spectroscopy system for studying a region of a sample to be analysed, includes a magnetoresistive transducer made up of superposed planar layers, which receives a response signal of the sample; a system for making an AC current flow, at a supply frequency f.sub.c, through the transducer; a system for generating a magnetic field H.sub.0 that is constant and uniform throughout a zone of interest in which the sample and transducer are placed; and an exciting coil to generate a magnetic field H.sub.1 that is uniform throughout the zone of interest and that varies at a resonant frequency f.sub.1; the field H.sub.0 is substantially perpendicular to the layers of the transducer. The system further includes a regulating system to ensure that the field H.sub.0 and the planar layers remain orthogonal, and a system for detecting a signal of frequency f.sub.cf.sub.1, f.sub.1f.sub.c or f.sub.c+f.sub.1.

This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.