Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The workstation and/or an operator of the workstation can be located outside a vicinity of an MRI device or other medical imaging device, and drive means for positioning the instrument can be located within the vicinity of the MRI device or the other medical imaging device. The instrument can be an MRI compatible laser probe that provides thermal therapy to, e.g., a tissue in a brain of a patient.

In a method, apparatus and medical imaging system to generate image data based on magnetic resonance (MR) thermometry data, planning data of a region of an examination subject that is to be depicted thermometrically are provided to a processor. Through the processor, segmentation data based on the planning data are generated MR thermometry data are provided to the processor, which generates image data on the basis of the MR thermometry data, using the segmentation data.

In a method for filtering magnetic resonance (MR) image data, complex MR image data is acquired from a region to be imaged, and a sliding window averaging is applied to the complex MR image data to generate filtered MR image data. For each window position of the sliding window averaging: a phase variation of the complex MR image data of individual image points of a sliding window is estimated with a model using a linear phase progression, and filtered complex MR image data is generated based on the estimated phase variation of the complex MR image data. The generation of the filtered complex MR image data uses an average formation of the complex MR image data of the individual image points of the sliding window.

The present disclosure describes methods and systems, including computer-implemented methods, computer program products, and computer systems, for measuring wettability of a rock sample. One method includes: at each temperature of a plurality of temperatures, obtaining a first Nuclear Magnetic Resonance (NMR) surface relaxation time for a rock sample having a saturation level; determining a first temperature sensitivity based on the first NMR surface relaxation times and corresponding temperatures; at each temperature of the plurality of temperatures, obtaining a second NMR surface relaxation time for the rock sample that is saturated with oil; determining a second temperature sensitivity based on the second NMR surface relaxation times and corresponding temperature; and determining a wettability of the rock sample based on the first temperature sensitivity and the second temperature sensitivity.

The present disclosure describes methods and systems, including computer-implemented methods, computer program products, and computer systems, for measuring wettability of a rock sample. One method includes: at each temperature of a plurality of temperatures, obtaining a first Nuclear Magnetic Resonance (NMR) surface relaxation time for a rock sample having a saturation level; determining a first temperature sensitivity based on the first NMR surface relaxation times and corresponding temperatures; at each temperature of the plurality of temperatures, obtaining a second NMR surface relaxation time for the rock sample that is saturated with oil; determining a second temperature sensitivity based on the second NMR surface relaxation times and corresponding temperature; and determining a wettability of the rock sample based on the first temperature sensitivity and the second temperature sensitivity.

A pH calculating apparatus according to an embodiment includes processing circuitry that obtains a Z spectrum generated from a CEST imaging process by using, for a subject, a contrast agent containing types of substances having mutually-different responsiveness to pH during chemical shift imaging and including fall points of signal values corresponding to the types of substances; obtains information related to the subject; calculates a pH dependent value by using MR signal values corresponding to the fall points of the signal values; selects a standard curve indicating a pH value corresponding to the pH dependent value in accordance with the information, from among standard curves prepared in advance in accordance with the information; and determines a pH value based on the selected standard curve and the pH dependent value.

A system for guiding a medical intervention is disclosed. The system employs a device guide that operates on the surface of a sphere that is centered on a selected target.

In some embodiments, the present disclosure pertains to a method of delivery of an active agent to a target tissue, in a subject in need thereof comprising positioning a high intensity focused ultrasound transducer to enable delivery of ultrasound energy to the target tissue. Such a method comprises energizing the high intensity focused ultrasound transducer; imaging at least a portion of the target tissue; and discontinuing delivery of ultrasound energy. Further, such a method may comprise administering the active agent to the subject under the conditions of thermal stimulation. In another embodiment, the present disclosure relates to a method of treating a tumor in a subject in need thereof comprising administering a therapeutic agent to the subject and providing thermal stimulation to the tumor. In some embodiments, there is provided a method for increasing the efficacy of a therapeutic agent in a target tissue.

An MRI phantom having an MRI compatible temperature measurement device having an MRI compatible body containing an MRI compatible fluid, wherein the device senses accurate temperature measurement within an MR Scanner environment using image processing of the contrast in signal between the areas of the image around the device and the fluid contained within the body of the device. The MRI Phantom may further include an internal expansion bladder device accomodating internal changes in pressure within the phantom, wherein the internal expansion bladder device includes frames supporting a pair of spaced membranes defining a chamber filled with a compressible gas.

A system and method to analyze image data. The image data may be used to assist in determine the presence of a feature in the image. The feature may include a bubble.