Vascular filters and deflectors and methods for filtering bodily fluids. A blood filtering assembly can capture embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature. A blood deflecting assembly can deflect embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature.

Intraocular lens and methods for optimization of depth of focus and the image quality in the periphery of the visual field. The intraocular lens (600) comprises a central part and a peripheral part, the central part being the optical part (600) and the peripheral part comprising mechanical fasteners (603), and the central part comprises: an aspherical concave anterior surface (601), which is the surface closest to the iris of the eye once the lens (600) has been implanted in the eye, and an aspherical convex posterior surface (602), which is the surface closest to the retina of the eye once the lens (600) has been implanted in the eye, such that the radius of curvature of the posterior surface (602) of the central part is smaller than the radius of curvature of the anterior surface (601) of the central part, with a ratio between radii of between 2 and 6, and the mechanical fasteners (603) are arranged at an angle (605) of between 0° and 10° with respect to a plane passing through the joints between the central part and the peripheral part and which is perpendicular to the optical axis of the eye in which the lens (600) is intended to be implanted.

A shunt for draining ocular fluid of one embodiment includes a tubular body formed of a mesh material including bioactive glass fiber and collagen, the tubular body including an implantation member and a conduit through the implantation member. The implantation member and the conduit are formed integrally. Other embodiments are also contemplated.

A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

A transcatheter stent-valve having replacement leaflets that are attached along their free edges. The stent-valve frame has supports that extend distally of the replacement leaflets to two fastening sites. The replacement leaflets are attached along a leaflet base forming a linear attachment to the stent-valve frame. The free edges of the leaflets have cords attached; the cords attach the free edges of the leaflets to the fastening sites located on the supports. The stent-valve can be a single component stent-valve or it can be a second component of a dual component stent-valve.

Reversibly deformable corneal implants for replacing excised corneal tissue, the implants including an optical portion and an anchoring portion having different mechanical properties from each other.

A prosthetic capsular device configured to be inserted in an eye after removal of a lens, in some embodiments, can comprise a housing structure comprising capable of containing an intraocular device. The housing structure can comprise an anterior portion comprising an anterior opening, a posterior portion comprising a posterior opening, and a continuous lateral portion between the anterior portion and the posterior portion.

Accommodating intraocular lenses including an optic having an anterior element and a posterior element defining an optic fluid chamber, wherein the optic is aspheric across all powers throughout accommodation or disaccommodation. Intraocular lenses, optionally accommodating, where an optic portion is centered with a midline of a height of the peripheral portion, the height measured in the anterior to posterior direction.

Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve can include an annular frame having an inflow end, an outflow end and a central longitudinal axis extending from the inflow end to the outflow end. The valve can include a valvular structure including two or more leaflets, each of the two or more leaflets having a leaflet inflow edge positioned at least partially outside of the frame and a leaflet outflow edge positioned within the frame, wherein at least a portion of each of the leaflet inflow edges is unsupported by the frame.

The disclosure relates to winged graft devices, methods of manufacture, and methods of use to repair, e.g., repair perforations, in tympanic membranes, or to augment defective tympanic membranes.