Endovascular stents and endovascular device platforms and related methods that allow for the modulation/regulation of vascular flow to treat certain disease states are provided. In particular, a covered endovascular stent is provided that, upon deployment, is configured to an installed shape. A balloon catheter comprising a stem and an angioplasty balloon on an end of the stem can be provided to expand the stent. The angioplasty balloon can have a dumbbell shape when inflated with a first head on a first end of the angioplasty balloon having a first outer diameter and a second head on a second end of the angioplasty balloon having a second outer diameter and a narrow center portion having a third outer diameter that is less than the first outer diameter of the first end and the second outer diameter of the second end of the angioplasty balloon. Thereby, the covered stent configured in the installed shape can comprise a dumbbell shaped tubular structure having a first inner diameter of a first end portion and a second inner diameter of a second end portion that are larger than a third inner diameter within a center portion of the tubular structure.

Apparatus and methods are provided for flaring a stent deployed within a branch vessel including an ostium communicating with a main vessel, a first end of the stent extending at least partially from the branch. A catheter is provided that includes a balloon having a reinforced region adjacent an unreinforced region. When the balloon is positioned at a desired location, e.g., within a stent, prosthetic valve, or other tubular prosthesis, the balloon may be inflated to a first pressure causing the reinforced and unreinforced regions to expand substantially simultaneously. Upon inflation of the balloon beyond the first pressure, the reinforced region of the balloon remains at the first diameter and the unreinforced region continues to expand, e.g., to flare one or more ends of the prosthesis.

Systems and methods for mitral valve repair having a docking station and a valve implant. The docking station is an anchoring device having a helix structure. The valve implant is made of an expandable frame and a valve, and is radially expandable to a diameter that is at least the same as an expanded diameter of the anchoring device. The method of delivering the docking station and valve implant is performed by inserting the components through device delivery catheters.

A multi-lumen stent graft including a tubular main body stent graft and a tubular connection stent graft; the main body stent graft includes a tubular main body stent; the main body stent includes a tubular main body covering and a main body support frame fixed on a wall of the main body covering; a main lumen and at least one sub lumen are separated axially by a separation covering within the main body stent; in a released state, a proximal end of the connection stent graft and the main lumen at a distal end of the tubular main body stent graft are fitted and connected together. The multi-lumen stent graft is not prone to endoleaks and displacement, which can simplify surgical operations, reduce the difficulty and risk of surgery, and has a wide range of applications.

A multi-lumen implantable device configured to deliver a therapeutic agent to a selected portion of a blood vessel is disclosed. As one example, an implantable device includes a first lumen configured to flow blood from an upstream end to a downstream end of the device when implanted in a blood vessel; a second lumen fluidly separated from the first lumen and configured for introducing a therapeutic agent to a selected, first portion of a wall of the blood vessel, between the upstream end and the downstream end of the device; and at least one sealing member configured to block the therapeutic agent from entering a second portion of the wall of the blood vessel, between the upstream end and the downstream end of the device.

An implantable prosthesis valve device and a method for implanting the same are provided. The device includes a frame body. The frame body includes a valve leaflet fixing portion for fixing prosthetic valve leaflets, and a first fixing portion located at one end portion of a frame. In an axial direction, the frame body further includes a first buffer portion located between the first fixing portion and the valve leaflet fixing portion, and a second buffer portion located between the other end portion of the frame body and the valve leaflet fixing portion, wherein at least one of the first buffer portion and the second buffer portion has an elasticity in the axial direction.

A braided stent having a plurality of retrieval and/or repositioning levers includes a stent body formed of a plurality of wires interbraided in a braided pattern. The repositioning and/or retrieval levers have a loop portion extending radially away from the stent body and first and second legs extending along the stent body. The levers are configured to be actuated radially inward toward the central longitudinal axis of the stent by a radially inwardly directed force to radially collapse the stent.

Systems and methods for the manufacture of an hourglass shaped stent-graft assembly comprising an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilatation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium. The encapsulated stents may also be used to treat pulmonary hypertension.

The invention is devices and methods to treat benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms infections (LUTS). The devices are intra-urethral implants placed in a patient in need thereof by minimally invasive procedures, preferably under local anesthesia in an office environment. The devices are sized and designed for atraumatic insertion and expansion within the urethra to engage and retract enlarged prostatic tissue proximate to the urethra that is leading to adverse symptoms associated with BPH. The methods include steps to deploy the implant devices of the invention using a delivery system of the invention and at target prostatic tissue that is visualized during the procedure and yields a reduction in the symptoms of BPH.