A minimally-invasive annuloplasty ring for implant at a mitral annulus. The annuloplasty ring has an inner core member with a C-shaped plan view that generally defines an oval with a major axis and a minor axis, and is symmetric about the minor axis. A posterior portion of the core member bisected by the minor axis has a thicker radial dimension than a pair of free end regions terminating on an anterior side of the core member. The radial thickness smoothly transitions between the posterior portion and the end regions. The inner core member may be covered with a fabric, and is a superelastic metal so that it can be straightened out and delivered through an access tube. The curvatures and thicknesses around the core member are selected so that the strain experienced when straightened does not exceed 7-8%.

An implant includes a primary structural element, and two clips coupled to the primary structural element, on opposite lateral sides of the primary structural element from each other, each of the clips having a first clip element and a second clip element. The implant is transluminally advanced to a heart valve of a subject. The implant is coupled to leaflets of the valve (i) by, for each of the clips, closing the clip around a central part of a respective leaflet of the valve by causing deflection between the first clip element and the second clip element, thereby sandwiching the central part of the respective leaflet between the first clip element and the second clip element, and (ii) such that the leaflets form a double orifice configuration, with the primary structural element disposed between the central parts of the leaflets. Other embodiments are also described.

A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments. The segments may be orthogonal or oblique to the outer surface of the tubular stent.

The present invention relates to an integrated radial silicone-filled cell-structured for human body implant and manufacturing method thereof, and more particularly, in a human body implant, to an integrated radial silicone-filled cell-structured human body implant comprising: a first silicone-filled cell including a silicone filling material, in which the silicone filling material is formed in the center of the implant; and a second silicone-filled cell surrounding an outer surface of the first silicone-filled cell, being formed radially around the center of the implant, and including a silicone filling material formed with a cross-linking density different from a silicone cross-linking density of the first silicone-filled cell.

Described herein are devices for placement in surgically created soft tissue spaces, potential spaces, or cavities. The implantable devices generally include a bioabsorbable body having an open framework that facilitates attachment of tissue thereto in a manner that helps avoid post-surgical deformities. Methods for using the implantable devices in oncoplastic surgery are further described.

A method is presented for tricuspid valve commissural annuloplasty for secondary tricuspid insufficiency. The method comprises suturing through a valve annulus, and bringing the valve annulus to its normal size while eliminating its regurgitation. The suturing comprises applying individual sutures on pledgets through the tricuspid valve annulus from a right ventricle side along anteroposterior and posteroseptal commissures on both sides of each of said commissures, spaced-apart from them; taking out needles of said sutures from a right atrium side and tying knots along the commissures between them.

An edentulous mouth insert appliance for mounting upon the edentulous gum of a patient, comprises a u-shaped frame formed of a rigid flexible material, with a portion to embrace the gum and a portion extending beyond the gum with an exposed surface to replicate a bite aligned with the corresponding occlusal plane. The frame has a base supporting a pair of inner and outer side walls spaced apart by the base a distance allowing the frame to encircle and cover the edentulous gum with a space between inner surfaces of the frame and the gum. A fill within the frame fills the space between the frame and the gum upon which the appliance is fitted, providing a void-free seal between the apparatus and the gum.

A horseshoe-shaped guide catheter for stent angioplasty of the ductus arteriosus in newborn and infants with ductal-dependent cardiopathies, characterized by a long, straight, hollow first section merged at the distal end thereof to a second section formed by a curved portion shaped as a circle section with radius (Ra) of 7.5 mm to 9 mm, arc (b) of 180° to 280° and distance (d) between the tip of the second section and the straight part of the first section without deformations of 7 mm and 15 mm. The angioplasty makes it possible to insert one or more stents that keep the ductus open in extrauterine life, improving survival of the newborn and young infants, allowing weight gain and undergo corrective surgery a few months later with safer and with better outcomes.

Embodiments of the present disclosure are directed to stents, valved-stents, and associated methods and systems for their delivery via minimally-invasive surgery.