The present disclosure provides a kirigami-inspired injectable stent system. The stent systems and methods enable radial/circumferential and longitudinal delivery of an extended release of therapeutics within tubular structures of the body, such as the GI tract and trachea. According to some aspects, a kirigami-based injectable stent system is provided that can enable drug release through deposition of therapeutic-coated needles of the stent in the tubular mucosa, such as often found in the gastrointestinal tract or trachea.

A vaginal device and method of preventing urinary incontinence is disclosed. The device includes a longitudinal portion having a geometrical centre line, a first end and a second end, the first end being the innermost of the vaginal device during use, at least one supporting portion protruding from the longitudinal portion at the first end, the at least one supporting portion being configured to support against the urethra, through the vaginal wall, at a site located adjacent the maximal urethral pressure point, and a reference member protruding from the longitudinal portion at the second end, wherein the reference member during use is fixated against the vaginal introitus, holding the vaginal device securely fixated inside of the vagina and ensuring the at least one supporting portion is arranged at the intended site. The device further includes a section of the longitudinal portion, arranged between the supporting portion and the reference member, that has a decreasing cross-section towards the reference member and/or has at least one notch, groove and/or slot in an outer surface along an axial direction of the section.

A drainage stent delivery system is disclosed. The drainage stent delivery system includes a catheter body, a stent member, and a coupling member. In some embodiments the coupling member can include keyed connectors having a non-round shape to facilitate a 1:1 rotation ration of the catheter body and the stent member. In another embodiment, the coupling member can include a telescoping connector having an inner tube and a release wire disposed through the inner tube. A distal portion of the release wire has an outer diameter greater than an inner diameter of the inner tube such that the telescoping connector can be displace by the release wire. In another embodiment, the stent member includes a proximal retention member having arms that are outwardly extendable.

A joining arrangement between a main tube (3) and a side arm (5) in a side arm stent graft (1). The side arm (5) is stitched into an aperture (11) in the main tube and is in fluid communication with it. The aperture is triangular, elliptical or rectangular and the side arm is cut off at an angle to leave an end portion having a circumferential length equal to the circumference of the aperture. The side arm can also include a connection socket (76) comprising a first resilient ring (79) around the arm at its end, a second resilient ring (80) spaced apart along the arm from the first ring and a zig zag resilient stent (82) between the first and second rings. The zig-zag resilient stent can be a compression stent. Both the main tube and the side arm are formed from seamless tubular biocompatible graft material.

A flow diversion device for the treatment of intracranial aneurysms and other medical conditions is disclosed. The flow diversion device may include a generally tubular wire stent frame formed from a plurality of zig-zag shaped wire elements that are coupled together. The device further includes a base layer of graft material coupled to the wire stent frame and surrounding at least a portion thereof, the wire stent frame maintaining the base layer in an open condition. In some embodiments, the base layer may be formed of porous graft material having a plurality of slits formed in the longitudinal direction. The slits may have a different shape in a compressed configuration and an expanded configuration. The slits provide a passageway for a small blood flow to maintain the long-term patency of important small side branches, while also reducing blood flow to the aneurysm to promote occlusion and avoid potential rupture.

There is provided herein a bone anchored implant that is used to support a nasal prosthesis in patients with a missing external nose. The implant consists of central section (which is preferably generally triangular) suspended within the aperture of the nasal cavity by four fixation arms which extend radially to engage the surrounding maxillary bone. The triangular portion may support three fixation points, one at each corner of the triangular portion, which in turn, directly engage the nasal prosthesis either via magnets or mechanical locking interface. Extending radially from the triangular section, the four fixation arms may flatten to a clover leaf arrangement of three apertures which accommodate micro-screws that secure the implant to the surrounding maxillary bone.

The present invention relates to devices and methods for improving the function of a defective heart valve, and particularly for reducing regurgitation through an atrioventricular heart valve—i.e., the mitral valve and the tricuspid valve. For a tricuspid repair, the device includes an anchor deployed in the tissue of the right ventricle, in an orifice opening to the right atrium, or anchored to the tricuspid valve. A flexible anchor rail connects to the anchor and a coaptation element on a catheter rides over the anchor rail. The catheter attaches to the proximal end of the coaptation element, and a locking mechanism fixes the position of the coaptation element relative to the anchor rail. Finally, there is a proximal anchoring feature to fix the proximal end of the coaptation catheter subcutaneously adjacent the subclavian vein. The coaptation element includes an inert covering and helps reduce regurgitation through contact with the valve leaflets.

A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

The present disclosure discloses a swimming earplug, which comprises an ear cap and a bracket, wherein the ear cap is a soft rubber ear cap, an ear cap through hole is provided at the center of the ear cap, the ear cap through hole penetrates the front and rear ends of the ear cap, an insertion post is formed at the front end of the bracket, the insertion post is inserted into the ear cap through hole and snugly fitted with the ear cap through hole, a bracket, through hole is provided in the bracket, the front end of the bracket through hole extends to a front end face of the insertion post such that the bracket through hole and the ear cap through hole communicate with each other, a rear end opening of the bracket through hole is covered with a waterproof and breathable membrane, and the waterproof and breathable membrane is fixedly connected to the bracket. Through the present disclosure, it is possible to effectively prevent water from entering an ear, the wearing comfort is better, and outside sounds can be heard clearly.

A prosthesis configured to be implanted in a cornea of an eye, to interconnect host tissue with a corneal graft, is disclosed herein. The prosthesis can include a body and a slit. The body can extend between first and second ends. The body can define a section of maximum width between the ends. The body can narrow at the ends and converge to first and second tips. The slit can be defined in the body at the first end and can have a width. A portion of the body between the second tip and the section of maximum width can have a width that is less than the width of the slit, whereby the portion of the body between the second tip and the section of maximum width is receivable in the slit.