The invention relates to a mechanical prosthetic heart valve (10) comprising an annular support (12) having an internal peripheral wall (14) centered about a longitudinal axis (X) and delimiting an internal passage, and at least two mobile leaflets (40), preferably three leaflets (40), arranged in such a way as to each be able to effect a rotational movement about an axis of rotation perpendicular to said longitudinal axis (X) so that the valve (10) can pass from a closed configuration to an open configuration and vice versa. Each leaflet comprises a central part (46), and two lateral winglets (48a, 48b) flanking the central part (46) symmetrically with respect to a plane of symmetry (Z) of the leaflet. Each winglet (48a, 48b) comprises one of two terminal portions (49a, 49b). The annular support (12) comprising two opposite edges (26, 28) and as many extensions (30) as the number of leaflets, which extend axially from one of the opposite edges (26, 28), a profiled recess (32) being created on two opposite sides of each extension (30), the recesses (32) acting as guide surfaces for the respective terminal portions (48a, 48b) of each leaflet (40) as the valve (10) passes from an open configuration to a closed configuration, and vice versa. A contact zone of each leaflet (40) in the open position with the internal peripheral wall (14) is less than 15% of the total width of the leaflet (40) extending between the extremities of the two terminal portions (49a, 49b).

Methods and assemblies for attaching leaflets to a frame of a prosthetic heart valve using a connecting skirt are disclosed. As one example, a prosthetic heart valve can include a frame, a valvular structure mounted within the frame and comprising a plurality of leaflets, each leaflet comprising tabs on opposite sides of the leaflet and a cusp edge portion, and a plurality of connecting skirts. Each connecting skirt comprises side base portions and a central portion connected to each of the cusp edge portion of a corresponding leaflet and struts of the frame, each connecting skirt further comprising side extension portions that extend away from the cusp edge portion along a length of the frame, where each side extension portion of each connecting skirt extends across struts of the frame, between cusp edge portions of adjacent leaflets and connects to an adjacent side extension portion of an adjacent connecting skirt.

A device for lowering intraocular pressure is disclosed herein. In an example, the device includes a continuous plate structure that enables aqueous humor to flow from a first end to a second end. The first end has a maximum width that is narrower than a maximum width of the second end. The continuous plate structure includes an uppermost surface opposite a lowermost surface, the uppermost surface including a plurality of open cells. The continuous plate structure also includes a fluid pathway including a plurality of open channels formed into the lowermost surface. The open channels are configured in an intersecting grid pattern extending from the first end to the second end of the continuous plate structure. The open channels provide for the flow of aqueous humor, thereby reducing intraocular pressure.

Described embodiments are directed toward prosthetic valve leaflets of a particular shape that allows redundant coaptation height in the leaflets when a planar segment is present in each leaflet.

A method of reducing regurgitation between native leaflets of an atrioventricular heart valve includes advancing a delivery catheter through a sheath, wherein the delivery catheter has a valve leaflet coaptation element mounted over a distal end portion. The coaptation element is positioned within the heart valve and is permitted to radially expand from a compressed configuration to an enlarged configuration for filling a gap between the native leaflets of the heart valve. After deployment, the position of the coaptation element is fixed relative to the heart valve, thereby reducing regurgitation between the native leaflets of the heart valve and improving heart function.

A collapsible and expandable stent body includes a generally tubular annulus section, one or more prosthetic valve elements mounted to the stent body, and a cuff attached to the stent body. The prosthetic valve is operative to allow flow in an antegrade direction but to substantially block flow in a retrograde direction. The prosthetic heart valve may include paravalvular leak mitigation features in the form of first and second sealing members. The sealing members are attached to the cuff and extend circumferentially around an abluminal surface of the stent body. The sealing members each have an open side facing in a first axial direction and a closed side facing in an opposite second axial direction. Flow of blood in the second axial direction will tend to force blood into the sealing members and cause the sealing members to billow outwardly relative to the stent body, helping to mitigate paravalvular leak.

A self-gripping hernia prosthesis including a layer of repair fabric and a plurality of tissue grips protruding from a surface of the repair fabric. The grip may be fabricated independent of the repair fabric and subsequently attached to the layer of fabric. A backing layer may be employed to secure each grip to the repair fabric. Each base may include a base that is located between the repair fabric and the backing layer. Alternatively, the base may be attached directly to the backing layer. The tissue grips may be configured to minimize entanglement with the repair fabric.

A stent includes a fluid-permeable stent body having longitudinally separated proximal and distal stent ends. The stent body has inner and outer stent body surfaces. The stent body defines at least one longitudinally extending primary lumen and at least two longitudinally extending secondary lumens laterally spaced from one another with at least a portion of the primary lumen interposed laterally therebetween. The secondary and primary lumens all are at least partially fluid-permeable between the inner and outer stent body surfaces. At least one fluid-impermeable and longitudinally extending berm is located directly laterally adjacent a corresponding secondary lumen. The berm prevents fluid flow laterally between at least a portion of the corresponding secondary lumen and a space laterally opposite the secondary lumen beyond the berm. A method of using the stent in at least partially extending a superior landing zone of an abdominal aortic aneurysm is also described.

Disclosed are methods and devices for isolating all three of the left subclavian, left common carotid and brachiocephalic arteries from embolic debris that might flow through the aortic arch, via a single access point. A system may include an elongate flexible tubular sheath, having a proximal end and a distal end, and an inner member extending through the sheath and moveable relative to the sheath. A left subclavian element may be supported by the inner member. A filter membrane may be configured to isolate the aorta from the brachiocephalic, left common carotid and left subclavian arteries when the left subclavian element is expanded within the left subclavian artery and the sheath is retracted to expose the membrane. The left subclavian element may include a self expandable frame, which may carry a left subclavian filter.

A medical device configured to perform an endovascular therapy can include an elongate manipulation member and an intervention member. The elongate manipulation member can include a distal end portion. The intervention member can include a proximal end portion and a mesh. The proximal end portion can be coupled with the distal end portion of the elongate manipulation member. The mesh can have a plurality of cells in a tubular configuration and being compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter and being self-expandable from the collapsed configuration to an expanded configuration. The mesh can include an anodic metal and a cathodic metal. The anodic metal and the cathodic metal can each form a fraction of a total surface area of the mesh.