A system for placement in at least one blood vessel includes a main graft body, one or more inflatable channels, and a filling structure. The one or more inflatable channels are attached to the main graft body. The filling structure is inflatable around at least a portion of the main graft body and at least a portion of at least one of the one or more inflatable channels. Various systems further include a graft extension that is insertable into a lumen formed by the main graft body, where the filling structure is inflatable around at least a portion of the graft extension. A method includes inserting a main graft body into a blood vessel, filling an inflatable channel attached to the main graft body, and filling a filling structure to inflate around at least a portion of the main graft body and at least a portion of the inflatable channel.

A method for treating regurgitation of blood flow through a diseased heart valve is provided. The diseased heart valve including an annulus, an anterior valve leaflet, a posterior valve leaflet and a subvalvular apparatus. The method includes providing an apparatus comprising a substantially annular support member, at least one infra-annular support member securely connected thereto, and at least one anchoring element associated with the at least one infra-annular support member. The method further includes attaching the substantially annular support member to the annulus of the diseased heart valve and attaching proximal and distal ends of a prosthetic chordae tendineae to the at least one anchoring element and a papillary muscle, respectively, so that the papillary muscle is caused to move medially.

Sphincter reinforcement devices are described. Sphincter reinforcement devices may be configured to be placed at least partially around a bodily passage at or near a sphincter. In one embodiment, a sphincter reinforcement device may comprise a ring including a tubular structure. The ring may be expandable. The tubular structure may be hollow. The tubular structure may have a first end and a second end. The first end may be configured to be coupled to the second end. The tubular structure may include a braided material.

Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Deployment systems and methods for using the deployment systems described herein facilitate implanting a two-part prosthetic heart valve that is arranged in a nested configuration during the transcatheter delivery and deployment processes.

Methods for treatment of aneurysms using a sequential manifold console to deploy multiple filling structures are provided herein. In one aspect, aneurysms are treated by simultaneously filling two double-walled filling structure using a sequential manifold console to guide a user in the steps to be followed in the procedure and to reliably achieve a consistent and durable aneurysmal treatment using a curable medium. The structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Pairs of filling structures delivered to the aneurysm from different access openings of a patient can be simultaneously prepared and pressurized from a single treatment console when treating abdominal aortic aneurysms using the described systems and methods.

The present technology relates to modular valve replacement systems for treating valve-related cardiac disorders. In select embodiments, the modular valve replacement system includes a fixation device and a permanent valve assembly. The fixation device and the permanent valve assembly are delivered separately, enabling use of smaller delivery systems and facilitating less-invasive implant techniques. The fixation device is implanted first and provides a mounting fixture for the subsequently delivered permanent valve assembly. In some embodiments, the permanent valve assembly is at least partially mechanically isolated from the fixation device after the permanent valve assembly is attached to the fixation device. In some embodiments, the fixation device includes a temporary valve assembly that prevents regurgitation until the permanent valve assembly is implanted.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

Docking stations are configured to retain and position a transcatheter heart valve in a circulatory system. The docking stations can comprise an expandable frame. The docking stations can include an enlarged first end portion having a first outer radial portion with a first major lateral dimension, an enlarged second end portion having a second outer radial portion with a second major lateral dimension, and a narrowed central waist portion having an inner radial portion with a third major lateral dimension smaller than the first and second major lateral dimensions. A retaining portion is at least partially defined by at least one of the first and second end portions, and a valve seat is at least partially defined by the waist portion. The docking station can be configured to adapt a native tricuspid valve to accept a smaller transcatheter heart valve.

A heart valve prosthesis stent comprises an inner stent and an outer stent. The outer stent comprises an outer body section and an outer skirt section which extends from the outer body section and is located on the radial outer side of the outer body section. The inner stent comprises an inner body section at least partially located in the outer stent and an inner skirt section protruding out of the radial outer side of the inner body section from an inflow end of the inner body section. The inner skirt section (32) outwardly protrudes out of the radial outer side of the inflow end of the outer body section, the outer skirt section, the inner skirt section and the section of the outer body section located between the outer skirt section and the inner skirt section jointly form an accommodating space with an outward opening.

Aortic repair devices and associated systems and methods are disclosed herein. An aortic repair device configured in accordance with embodiments of the present technology can include a base member configured to be implanted in an aorta proximate to a diseased portion of the aorta, such as an aneurysm or dissection. The base member can direct blood flow past the diseased portion of the aorta to perfuse a portion of the aorta distal of the diseased portion and/or various branch vessels. In some embodiments, one or more spanning members or other implants can be coupled (e.g., docked) to the base member during the same or a separate intravascular procedure to provide additional flow paths past the diseased portion.