The present teachings provide a device and methods of making and using thereof. Specifically, one aspect of the present teachings provides a self-expandable device with a braided structure comprising a shunt, a distal retention flange, and a proximal retention flange. Upon the device being deployed at a treatment location, the distal retention flange or the proximal retention flange transitions to have a diameter that is greater than the diameter of the shunt portion. And the shunt portion has a braid angle . Another aspect of the present teachings provide that the ratio of flange/shunt diameter equals or greater than 1/sin . Yet another aspect of the present teachings provides an axial constraining mechanism to reinforce the shunt portion.

Using a sling that includes a central portion and at least two arms extending from the central portion, a method of treating anal incontinence may include positioning the central portion posteriorly to the rectum and/or anus of a subject, and extending each arm of the sling to a respective obturator region. Using a sling having the same or similar structure, a method of treating pelvic organ prolapse may include positioning the central portion beneath the anorectum of a subject, and extending each arm of the sling to a respective thigh incision near the obturator region.

A hair implant suitable for subcutaneous implantation is provided having an anchor comprising an anchor body, and at least one collagen receiving structure selected from the group consisting of at least one tunnel disposed through the anchor body and an external surface feature of the anchor body. The anchor further comprises at least one hair strand projecting from a distal end of the anchor body, wherein the at least one collagen receiving structure is configured to support collagen ligature growth after subcutaneous implantation of the hair implant to anchor the anchor to a hair implant recipient, and the collagen receiving structure is free of hair. A fracture line in the anchor body allows the body to fragment, thereby releasing collagen ligatures and allowing the implant fragments to release and fall out of the skin. The at least one hair strand may comprise a primary hair element with emerging hair elements.

A tissue anchor delivery device includes a handle, an elongate shaft projecting from the handle, a carrier configured to linearly translate within the handle, an elongate pusher shaft disposed at least partially within a lumen of the elongate shaft, a pusher hub coupled to the pusher shaft, the pusher hub being movably disposed within the handle and releasably coupled to the carrier, an elongate needle movably disposed at least partially within a lumen of the pusher shaft, a needle hub coupled to the needle, the needle hub being movably disposed within the handle and releasably coupled to the carrier, a suture having one or more strands that pass through at least a portion of lumen of the needle, a tissue anchor associated with a distal portion of the suture, and an actuator configured to cause movement of the carrier.

An intracranial stent includes a proximal end portion having a first diameter, a distal end portion having a second diameter, and a central portion located between the proximal end portion and the distal end portion, the central portion having a third diameter, the third diameter being less than the first diameter and less than the second diameter. The intracranial stent includes patterns of interstices, interstices in the central portion having areas that are smaller than areas of the interstices in the proximal end portion and in the distal end portion when the intracranial stent is in the expanded state. The intracranial stent has an unexpanded state in which diameters of the proximal end portion, the distal end portion, and the central portion are smaller than the first diameter, the second diameter, and the third diameter, respectively.

Heart valve replacement often involves complications associated with paravalvular leaks. Vascular plug and occlusive devices, as well as heart valves particularly beneficial in treating the phenomenon of paravalvular leaks are described to address this issue.

Systems, apparatuses, and methods disclosed herein are provided for medical treatment, including transcatheter medical treatments and/or for treatment of dilated hearts (e.g., dilated left ventricle) or functional mitral valve regurgitation within a human heart. The systems, apparatuses, and methods disclosed herein may include applying one or more heart splints to the patient's heart to apply pressure to the heart to reshape the heart. Anchors disclosed herein may be utilized in plugs for treating openings in a septum between two chambers of a heart, e.g., ventricular septal defects (VSD), atrial septal defects (ASD), and patent foramen ovale (PFO). In addition, the anchors disclosed herein may be utilized to reshape an annulus of a patient's heart valve, including a tricuspid valve of a patient's heart. The anchors disclosed herein may also be utilized to reposition a heart valve leaflet to reduce heart valve leaflet prolapse.

An intracranial stent includes a proximal end portion having a first diameter when the intracranial stent is in an expanded state, a distal end portion having a second diameter when the intracranial stent is in the expanded state, a central portion located between the proximal end portion and the distal end portion, the central portion having a third diameter when the intracranial stent is in the expanded state, the third diameter being less than the first diameter and less than the second diameter, and a proximal transition portion extending from the proximal end portion to the central portion, the proximal transition portion having a substantially frustoconical shape such that the proximal transition portion transitions from the first diameter to the third diameter. The intracranial stent also includes a distal transition portion extending from the distal end portion to the central portion, the distal transition portion having a substantially frustoconical shape.

A cardiac device comprises a first anchoring element configured to be attached to a first side of a tissue wall, a second anchoring element configured to be attached to a second side of the tissue wall, and a cinching device. The cinching device is configured to attach to the first anchoring element and the second anchoring element and apply force to the first anchoring element to move the first anchoring element towards the second anchoring element and at least partially compress the tissue wall.

Systems, apparatuses, and methods disclosed herein are provided for medical treatment, including transcatheter medical treatments and/or for treatment of dilated hearts (e.g., dilated left ventricle) or functional mitral valve regurgitation within a human heart. The systems, apparatuses, and methods disclosed herein may include applying one or more heart splints to the patient's heart to apply pressure to the heart to reshape the heart. Anchors disclosed herein may be utilized in plugs for treating openings in a septum between two chambers of a heart, e.g., ventricular septal defects (VSD), atrial septal defects (ASD), and patent foramen ovale (PFO). In addition, the anchors disclosed herein may be utilized to reshape an annulus of a patient's heart valve, including a tricuspid valve of a patient's heart. The anchors disclosed herein may also be utilized to reposition a heart valve leaflet to reduce heart valve leaflet prolapse.