An assembly includes a delivery apparatus and a self-expandable prosthetic heart valve including radially extendable atrial protrusions and radially extendable ventricular protrusions. The prosthetic valve further includes a valve member supported by an annular body having the atrial protrusions and the ventricular protrusions coupled thereto. The delivery apparatus includes a first (distal) capsule portion and a second (proximal) capsule portion for retaining the prosthetic valve in a radially compressed, delivery state. The first capsule portion can be moved distally to allow the ventricular protrusions to expand, and the second capsule portion can be proximally retracted to allow the atrial protrusions to expand and transition to prosthetic valve to a radially expanded state. When implanted, the atrial protrusions are configured to engage an atrial side of a native heart valve, and the ventricular protrusions are configured to engage the ventricular side of the native heart valve.

A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.

Apparatus and methods are described including a valve frame (20) configured to support a prosthetic valve within a native atrio-ventricular valve. The valve frame (20) includes an atrial part (26) and a cylindrical part (22), to which the prosthetic valve leaflets (23) are coupled. A plurality of chord-recruiting arms (24) extend at least radially from the ventricular end of the cylindrical part (22). The chord-recruiting arms (24) are coupled to the ventricular end of the cylindrical part via stitches (82), and the stitches (82) are configured to act as hinges, such that upon being released from a radially-constrained configuration, while the cylindrical part (22) is held in an at least partially radially-constrained configuration, the chord-recruiting arms (24) are configured to extend radially outwardly by pivoting about the stitches (82) with respect to the cylindrical part (22). Other applications are also described.

A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising a plurality of circumferentially extending rows of angled struts, including first, second, and third rows of angled struts forming rows of diamond-shaped cells, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is disposed between the frame and the cusp edge portions, the skirt being sutured to selected struts of the frame along diagonal paths extending from an inflow end portion toward an outflow end portion. Each diagonal path along which the skirt is sutured to the frame extends along the first, second, and third rows of angled struts.

A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising first, second, and third rows of angled struts that define two circumferentially extending rows of diamond-shaped cells that extend continuously around the frame, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is connected to and disposed between the frame and the cusp edge portions of the leaflets, the skirt being connected to consecutive struts in the first, second, and third rows of struts with sutures. The compressed prosthetic heart valve can be mounted around the balloon and radially expanded to the expanded configuration with the balloon inside a patient's body.

A prosthetic heart valve having an inflow end and an outflow end includes a stent having a collapsed condition, an expanded condition, and cells arranged in circumferential rows. The stent has an anterior side configured to be disposed adjacent an anterior native valve leaflet and a posterior side configured to be disposed adjacent a posterior native valve leaflet. A valve assembly having a plurality of leaflets is disposed within the stent and a flange is disposed about the stent. The flange includes a flared portion adjacent the inflow end and a body portion extending from the flared portion to the outflow end, the flange extending between a first set of attachment points adjacent the inflow end, and a second set of attachment points adjacent the outflow end.

A medical assembly implanting a transcatheter heart valve in the heart at a valve deployment site and related methods of implantation and delivery. An anchor is endovascularly introduced into the heart and implanted to a cardiac wall with an anchor delivery system and delivery cable. A second delivery system introduces a tether which coupled to the implanted anchor and a transcatheter heart valve. The transcatheter heart valve includes either a top or bottom brim which is positioned to conform to the atrial floor at the deployment site.

An annuloplasty system is disclosed comprising an annuloplasty implant and a delivery device, the annuloplasty implant comprising first and second supports being adapted to be arranged on opposite sides of native heart valve leaflets. The delivery device comprising a locking structure to interlock with a correspondingly mating first locking structure of a delivery device connector of the annuloplasty implant, the locking structure comprising a first locking side to lock rotational movement of the annuloplasty implant, when interlocked with the delivery device, around an axial direction of the annuloplasty implant, and a second locking side to lock movement of the annuloplasty implant along said axial direction, when interlocked with the delivery device. A method of repairing a defective heart valve is also disclosed.

An implantable cerclage sacrocolpopexy medical device includes an elongate strip of flat, flexible material extending longitudinally from a first end to an opposite second end; a surgical needle attached to the first end of the elongate strip; and a loop at either the first end or the second end of the elongate strip. The medical device is positioned circumferentially around the cervix. The end of the elongate strip opposite the end having the loop is passed through the loop and attached to the sacrum or sacrospinous ligament.

A vascular stent, including an inner stent tube as well as a proximal support and a distal support which are arranged on an outer wall of the inner stent tube. When the vascular stent is in a compressed configuration, the proximal support and the distal support are both folded and close to the outer wall of the inner stent tube; when the vascular stent is expanded from the compressed configuration to an expanded configuration, a free end of the proximal support expands towards the distal end of the vascular stent, and a free end of the distal support expands towards the proximal end of the vascular stent. The vascular stent can be anchored to a main stent tube in a blood vessel by the proximal support and the distal support, preventing the vascular stent from shifting or becoming dislodged after being transplanted into the main stent tube.