Described herein are devices, systems, and methods for modifying blood flow and improving tissue oxygenation in an individual. More specifically, described herein are flow modifying implants, delivery systems, and methods of treatment using flow modifying implants. Also described herein are methods for preventing reperfusion injury in an individual using a flow modifying implant to prevent the reperfusion injury.

An endovascular prosthesis includes a stent-graft and an external coagulation inducer. The stent-graft includes a first portion of structural strut members and a first portion of a graft member, which, when the endovascular prosthesis is unconstrained in a radially-expanded state, together are shaped so as to define a blood-carrying tubular structure defining a lumen. The external coagulation inducer includes an extra-luminal skirt, which includes a second portion of the structural strut members and a second portion of the graft member, and is configured to assume: (i) when the endovascular prosthesis is removably disposed in a delivery sheath, a radially-compressed delivery state, in which the structural strut members of the first portion do not coincide with the structural stent members of the second portion, and (ii) when the endovascular prosthesis is unconstrained, a radially-expanded state, in which the extra-luminal skirt extends radially outward from an external surface of the stent-graft.

Spinal tissue distraction devices that include a member which has a pre-deployed configuration for insertion between tissue layers and a deployed configuration in which the member, by change of configuration, forms a support structure for separating and supporting layers of spinal tissue

A hair implant includes: (a) a hair strand anchor including: an anchor body; first and second hair chambers disposed within the anchor body; and at least one tunnel through the anchor body between the first and second hair chambers, where the tunnel is free of a hair; and (b) at least one hair strand having a portion thereof retained in at least one of the hair chambers; wherein the tunnel is configured to support collagen ligature growth after subcutaneous implantation by receiving and retaining collagen ligatures that anchor the hair implant to a hair implant recipient. Also disclosed is a hair implant including an anchor with first and second anchor bodies and at least one bridge connecting the anchor bodies and bridging at least one void between the anchor bodies, wherein the bridge supports and retains collagen ligature growth. Anchors, hair restoration and manufacturing methods are also disclosed.

Method and apparatus are disclosed for distracting tissue and particularly spinal tissue. The device and method may include insertion of at least one elongated member and an augmenting member to form a structure between the tissues to be distraction, such that a dimensional aspect of the structure is augmented upon movement of the augmenting structure.

Spinal tissue distraction devices that include a member which has a pre-deployed configuration for insertion between tissue layers and a deployed configuration in which the member, by change of configuration, forms a support structure for separating and supporting layers of spinal tissue.

A hair implant includes at least two strands including at least one of mammalian hair and synthetic hair; and an anchor, which: (a) includes silicone, (b) is configured for subcutaneous implantation, (c) includes a fracture line configured to facilitate fracturing of the anchor along the fracture line for ease of removal of the implant after subcutaneous implantation, and (d) is configured to provide a scaffold for collagen growth after subcutaneous implantation, wherein at least one of the at least two strands is joined to the anchor on one side of the fracture line and at least one of the at least two strands is joined to the anchor on an opposite side of the fracture line such that each fragment formed by fracturing the implant includes at least one of the at least two strands. Looped implants, a hair restoration method and an implant manufacturing method are also disclosed.

The present invention is directed to an adjustable corpectomy device which fits within the intervertebral distracted channel. The device includes a means for engaging an extendable member to accommodate the distracted channel. The corpectomy implant device is defined by a main body, a first expandable plate, and an opposing second expandable plate. Each expandable plate is adapted to fit within the main body in a compressed state, and extends away from the main body in a non-compressed, expanded state.

A pessary device includes a body and a finger-pull disposed on and extending from the body and is adapted to receive at least one finger of a user to facilitate removal of the pessary device. The finger-pull includes a loop extending from an outwardly facing surface of the body, in use, and an opposed anchoring section connected or integral with the outwardly facing surface. A method of producing a pessary device includes providing a finger-pull including a loop and an opposing anchoring section. The method includes forming a pessary body around the anchoring section, thereby securing the finger-pull to the pessary body.

Method and apparatus are disclosed for distracting tissue and particularly spinal tissue. The device and method may include insertion of at least one elongated member and an augmenting member to form a structure between the tissues to be distraction, such that a dimensional aspect of the structure is augmented upon movement of the augmenting structure.