A microtome including a microtome housing having a base portion, a front portion and a top portion, a microtome storage member associated with the top portion of the microtome housing, and a sample sectioning assembly associated with the front portion of the microtome housing, the sample sectioning assembly operable to cut sections from a sample.

A plastic film used for the purpose of depositing and transporting of thin slices of samples in the field of light microscopy.

A sample sectioning device including a housing having a base member, a cutting mechanism positioned on the base member and operable to cut sections from a sample, a sample holder dimensioned to hold a sample and operable to move with respect to the cutting mechanism during a cutting operation, and a waste removal assembly positioned below the cutting mechanism and the sample holder, the waste removal assembly having a first member and a second member that are dimensioned to remove waste produced during the cutting operation.

Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.

A method of producing thin sections using a microtome is disclosed. A hand wheel (32) is manually driven for producing a first thin section, and wherein the rotational movement of the hand wheel (32) is detected by an encoder (38), and a profile of the rotational movement is determined. The determined profile is stored and selected for production of at least a second thin section. A motor (24) is driven for generating a cutting movement between a cutting unit (16) and a sample holder (12) in accordance with the respective stored profile selected for producing the second thin section. A microtome (10) to carry out this method is also disclosed.

Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.

A microtome chuck including a mounting portion having a mating surface operable to removably attach the mounting portion to a sample sectioning device, and an electrical contact operable to electrically connect the mounting portion to a power source. The chuck further including a sample receiving portion coupled to the mounting portion, the sample receiving portion having a sample receiving surface dimensioned to receive a sample, a light source coupled to the sample receiving portion, the light source operable to emit a light from the sample receiving surface and through a sample positioned along the sample receiving surface, and circuitry electrically connecting the light source to the electrical contact of the mounting portion.

A sample sectioning device including a housing having a base member, a cutting mechanism positioned on the base member and operable to cut sections from a sample, a sample holder dimensioned to hold a sample and operable to move with respect to the cutting mechanism during a cutting operation, and a waste removal assembly positioned below the cutting mechanism and the sample holder, the waste removal assembly having a first member and a second member that are dimensioned to remove waste produced during the cutting operation.

A microtome including a microtome housing having a base portion, a front portion and a top portion, a microtome storage member associated with the top portion of the microtome housing, and a sample sectioning assembly associated with the front portion of the microtome housing, the sample sectioning assembly operable to cut sections from a sample.

A sample sectioning device including a cutting mechanism that is operable to cut sections from a sample, a sample holder operable to move relative to the cutting mechanism, the sample holder having a first side and a second side, the first side faces the cutting mechanism and is dimensioned to receive a sample, a light source coupled to the sample holder, wherein the light source is operable to emit a light from the first side of the sample holder and through a sample positioned on the first side, and a generator operable to generate an electrical energy for providing power to the light source.