A device for dark-field optical inspection of a substrate comprises: a light source for generating an incident beam that is projected onto an inspection zone of the substrate and that is capable of being reflected in the form of diffuse radiation; at least one first and one second collecting device; and a reflecting device for directing at least a portion of the diffuse radiation originating from a focal point of collection coincident with the inspection zone in the direction of the collecting devices, with a first and second reflective zone from which a first portion of the diffuse radiation is directed toward a first focal point, which is optically conjugated with the focal point of collection, and a second portion of the diffuse radiation is reflected toward a second focal point, which is optically conjugated with the collection focal point and distinct from the first focal point of detection.

A medical system includes a probe, an electro-optical measurement unit, and a processor. The probe is configured for insertion into a blood vessel of a brain, and includes two optical fibers, which include each an optical diffuser at distal ends thereof. One fiber is configured to guide an optical signal to a location along the blood vessel and to diffuse the optical signal so as to interact with a brain clot in the blood vessel. The other fiber is configured to collect the diffused optical signal that interacted with the brain clot at another location along the blood vessel. The electro-optical measurement unit is configured to transmit the optical signal to one optical fiber, and to receive and measure the diffused optical signal from the other optical fiber. The processor is configured to identify a composition of the brain clot by analyzing the measured diffused optical signal.

A method for stratifying a patient infected with a respiratory disease is disclosed. The method comprises providing (1510) a fluid sample (9) from the patient, producing (1520) a light signal from a laser (1), illuminating (1530) the fluid sample (9) with the light signal through a lens in a sensing probe (8), acquiring (1540) a spectrogram from the fluid sample (9), extracting (1550) a plurality of spectrogram features from the light signal, comparing (1560) the extracted plurality of spectrogram features with a model in a database to determine a degree of severity of the respiratory disease. A result is then output (1570) to indicate the degree of severity of the respiratory disease.

A system including a light source, sampling tray, and a plurality of fiber optics positioned to achieve high contrast to improve accuracy and eliminate the need to rotate the sample. A composite light image from the fiber optics is fed to a spectrometer which converts the reflected light into a fingerprint corresponding to the concentration of at least one substance in the sample. The fingerprint is processed by a statistical model to determine concentration level of the at least one substance in the sample and the concentration level is then displayed.

Embodiments of the invention generally relate to color and appearance metric measurements and, in particular, developing instrumentation to enable self-consistent image appearance measurements within instruments of unitary construction.

A scattering absorber measurement device includes a light source for outputting a plurality of light pulses having different wavelengths input to a scattering absorber, a photodetector for detecting each light pulse propagating inside the scattering absorber and output a detection signal, and a computation unit for calculating a reduced scattering coefficient and an absorption coefficient according to a time-resolved spectroscopic measurement method on the basis of the detection signal. The computation unit determines data related to a ratio of reduced scattering coefficients among wavelengths of the plurality of light pulses and calculates the reduced scattering coefficient and the absorption coefficient on the basis of a time-resolved measurement profile of each wavelength based on the detection signal and the data related to the ratio.

An optical apparatus for obtaining a reflectance spectrum includes a first means for generating a light, a second means for transferring and receiving the light on a substrate, a third means for collecting a diffusely reflected light, and a fourth means for separating the diffusely reflected light from a specular reflected light to obtain information about a concentration of a chromophore in the substrate. The second means is an optic probe made of Poly(methyl methacrylate) (PMMA) material including an inner rod and an outer rod, the inner rod is nested within the outer rod for collection and for illumination, the inner rod and the outer rod are coaxial, the inner rod is longer than the outer rod, the inner rod is isolated from the outer rod with a semi mirrored isolator, the reflected light is reflected from deep within the substrate by the inner rod.

An irradiation probe is, for example, an irradiation probe in which a plurality of optical fibers are bundled together, each of the optical fibers having, as at least a partial section in a longitudinal direction, a leakage section that outputs leakage light radially outward. Each of the optical fibers has directivity in which intensity of leakage light in a specific radial direction is higher than intensity of leakage light in another radial direction in a cross section intersecting an axial direction of the leakage section. The optical fibers are disposed apart from a central axis of the irradiation probe in radial directions different from each other, and the optical fibers are bundled together in a posture in which leakage light to the specific radial direction from the leakage section is directed radially outward of the irradiation probe.

Described herein is a protection factor evaluation system for determining a protection factor of a skin protection agent with a radiation source with exactly one LED, a detector unit with exactly one photodiode, a control unit and an evaluation unit. Furthermore, the invention relates to a method for determining a sun protection factor of a skin protection agent with the method steps of emitting radiation from precisely one LED of a radiation source, detecting remitted radiation with precisely one photodiode of a detector unit and evaluating the protection factor in an evaluation wavelength range, wherein the protection factor of the protection agent is evaluated from the radiation and a transmission spectrum, and wherein the data of the transmission spectrum for determining the protection factor are in silico and/or in vitro data.

The present disclosure provides systems and methods for characterizing and monitoring biological material. In one aspect, a method for characterizing biological material includes acquiring optical data associated with a biological material, and analyzing the optical data to determine optical properties of the biological tissue. The method also includes determining, using the optical properties, phase information corresponding to the biological material, and generating a report characterizing the biological tissue using at least the phase information.