A rotary valve 1 comprising a stator 3 and a rotor 5, wherein the stator comprises a plurality of connection ports (17a-17l) and orifices (19a-19l) and the rotor comprises a plurality of pairs of rotor valve orifices (23a-23h) joined by transfer channels (25a-25d). The rotor is able to be placed in different working positions whereby fluids can be fed to, for example, chromatography columns and/or can be bypassed through or around the valve. The invention also relates to a system comprising two components such as chromatography columns and a rotary valve.

A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve. The operations of the auxiliary and inject valves are coordinated in such a manner as to reduce sample carry-over and system pressure perturbations occurring during sample injection.

Described is a rotary valve that includes a stator, a rotor and a plurality of sample channels. The stator includes a stator surface having an inlet port, an outlet port and a plurality of selectable ports. The rotor includes a rotor surface having a first rotor channel and a second rotor channel. The rotor is configurable in a plurality of rotor positions, each of which couples the inlet port to one of the selectable ports through the first rotor channel and couples the outlet port to another one of the selectable ports through the second rotor channel. The two selectable ports are coupled to each other through one of the sample channels. The rotor has a bypass state defined by a rotor position, or angular range of rotor positions, at which the inlet port is coupled to the outlet port through the second rotor channel.

The present invention relate to a reactor comprising: (i) a first reagent release mechanism, (ii) a second reagent release mechanism, and (iii) a reaction area fluid pathway, wherein the reaction area fluid pathway comprises a pathway extension valve, wherein adjusting the pathway extension valve varies the length of the reaction area fluid pathway, and wherein the pathway extension valve comprises a single valve.

A multiple channel selector valve includes a stator and a rotor that is rotatable with respect to the stator. The rotor face includes first and second fluid flow paths for transferring fluids to selected sets of passages in the stator. The fluid flow paths in the rotor face are specifically configured to accommodate high fluid flow rate regimes while reducing flow restriction.

A fluid supply device for providing a mobile phase for a sample separating device includes, a supply conduit for providing a fluid which forms at least a part of the mobile phase, a fluid valve which is fluidically coupled with the supply conduit and, depending on its switching state, enables or prevents a passing of the fluid from the supply conduit, an elastic buffer unit which is fluidically coupled upstream of the fluid valve with the supply conduit and which is configured for buffering the fluid, and a fluid conveying unit for conveying the fluid which passes the fluid valve.

Systems for use with liquid chromatography for provision of continuous flow or gradient flow in connection with two pumps providing mobile phase to a valve.

A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

Provided are two-dimensional chromatography systems and methods for separating and/or analyzing complex mixtures of organic compounds. In particularly, a two-dimensional reversed-phase liquid chromatography (RPLC)—supercritical fluid chromatography (SFC) system is described including a trapping column at the interface which collects the analytes eluted from the first dimension chromatography while letting the RPLC mobile phase pass through. The peaks of interest from the RPLC dimension column are effectively focused as sharp concentration pulses on the trapping column, which is subsequently injected onto the second dimension SFC column. The system can be used for simultaneous achiral and chiral analysis of pharmaceutical compounds. The first dimension RPLC separation provides the achiral purity result, and the second dimension SFC separation provides the chiral purity result (enantiomeric excess).