Valve with two-piece stator assembly for use with liquid chromatography or other analytical systems. A separate and removable stator plate is provided with a mounting device to provide a two-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate.

An injector is configured for injecting a fluidic sample from an injector path into a mobile phase in a separation path between a fluid drive and a sample separation unit of a sample separation device. The injector includes a control unit configured for generating a first overpressure in a blocked first partial path of the injector path by a first pressure source, for generating a second overpressure in a blocked second partial path of the injector path by a second pressure source, for subsequently fluidically coupling the first partial path with the second partial path for generating an expansion stroke for releasing a gas bubble in the injector path, and for rinsing the released gas bubble from the injector path.

A sample delivery system for liquid chromatography is provided. The sample delivery system includes: a sample receptacle; a sample aspiration cannula for aspirating a sample located in the sample receptacle, the sample aspiration cannula being directed using a drive in a direction towards the sample receptacle so that a tip at a distal end of the sample aspiration cannula is immersed in the sample; and a guide element for the sample aspiration cannula provided above the sample receptacle, the guide element being designed as a washing device. The sample aspiration cannula can be retracted using the drive at least so far from the sample receptacle such that the distal end of the sample aspiration cannula may be cleaned in the washing device.

A controller (50) of a liquid chromatograph (1) is configured to execute, as an analysis operation in an analysis unit (3), a sample injection step of bringing a high-pressure valve (10) into a loading state, sucking a sample from a tip of a needle (12) to hold a sample in a sampling channel (2), then connecting the sampling channel (2) to an injection port (16) and bringing the high-pressure valve (10) into an injecting state, and supplying a mobile phase from a liquid supplier (6), thereby injecting a sample held in the sampling channel (12) into an analysis channel (4), and an analysis step of separating components of a sample injected into the analysis channel (4) in a separation column (14) by bringing the high-pressure valve (10) in the loading state and supplying the mobile phase from the liquid supplier (6) after the sample injection step is ended. In a case where at least a predetermined condition is satisfied, after the analysis step is ended, the controller is configured to execute, as the analysis operation, a system cleaning step of cleaning a liquid flowing route from the sampling channel (2) to the analysis channel (4) by connecting the sampling channel (2) to the injection port (16) and bringing the high-pressure valve (10) into the injecting state, and supplying the mobile phase and/or a cleaning liquid from the liquid supplier (6).

A multiple channel selector valve includes a stator and a rotor that is rotatable with respect to the stator. The rotor face includes first and second fluid flow paths for transferring fluids to selected sets of passages in the stator. The fluid flow paths in the rotor face are specifically configured to accommodate high fluid flow rate regimes while reducing flow restriction.

A flowpath switch valve is configured for extended service life by spreading the region, of the sliding surfaces of a stator and a rotor, that is subject to wear over the entirety of the sliding surfaces. The stator has fixed stator flowpaths, and the rotor has rotor flowpaths. A flowpath switch valve, depending on the rotor rotation state, realizes connection patterns that include: a first connection pattern wherein a rotor flowpath 241 connects a fixed stator flowpath 31 and a fixed stator flowpath 32; a second connection pattern wherein the rotor flowpath 241 connects the fixed stator flowpath 31 and a fixed stator flowpath 36; a third connection pattern wherein a rotor flowpath 242 connects the fixed stator flowpath 31 and the fixed stator flowpath 32; and a fourth connection pattern wherein the rotor flowpath 242 connects the fixed stator flowpath 31 and the fixed stator flowpath 36.

A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit. The sampling unit receives a fluidic sample, and the sampling volume temporarily stores an amount of the received sample. The retaining unit receives and retains from the sampling volume at least a portion of the stored sample, and has different retention characteristics for different components of the sample. A switching unit is coupled to the sampling path, a sampling fluid drive, a mobile phase drive, and a separating device. In a feed injection configuration of the switching unit, the mobile phase drive, the separating device, and the sampling path are coupled together in a coupling point for combining a flow from the sampling fluid drive containing the fluidic sample retained by the retaining unit with a flow of the mobile phase from the mobile phase drive.

Examples of the present disclosure describe systems and methods for detecting and mitigating stack pivoting exploits. In aspects, various “checkpoints” may be identified in software code. At each checkpoint, the current stack pointer, stack base, and stack limit for each mode of execution may be obtained. The current stack pointer for each mode of execution may be evaluated to determine whether the stack pointer falls within a stack range between the stack base and the stack limit of the respective mode of execution. When the stack pointer is determined to be outside of the expected stack range, a stack pivot exploit is detected and one or more remedial actions may be automatically performed.

The present invention relates to a method of loading a fluid into a fluidic element, wherein the method is performed in a fluidic system comprising the fluidic element, wherein the method comprises determining a volume that has flown into the fluidic element since a start time t.sub.start, and at a switching time t.sub.switch, switching the fluidic system to an operating state to stop flow into the fluidic element. The present invention also relates to a fluidic system configured for performing the method, and to a corresponding computer program product.

A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions. A first position of the at least two positions of the at least one valve increases the gradient delay volume of the chromatography system relative to when the at least one valve is in a second position.