A method for determining a state of a fluidic system can include measuring back pressures in the fluidic system at different times and determining a state of the fluidic system. The determination is based on at least the measured back pressures and on additional status information indicative of at least one status of the fluidic system at at least one of the different times.

The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. The valve (202) comprises a first position (304) wherein the inlet port is in fluid communication with the outlet port via a first fluid path comprising the detector and the column, wherein the detector is arranged upstream the column. The valve comprises a second position (404) wherein the inlet port is in fluid communication with the outlet port via a second fluid path comprising the detector and the column, wherein the detector is arranged downstream the column.

Tests of channels of a system as a whole can be easily performed without adding a complicated mechanism. A liquid feeding part includes a liquid feeding channel to feed a mobile phase, a drainage channel to release pressure in the liquid feeding channel, an analysis channel that discharges the mobile phase into the sample introduction part, and a channel switching valve that selectively connects the liquid feeding channel to one of the drainage channel and the analysis channel. The channel switching valve is configured to be able to provide a tight stopper state in which the liquid feeding channel is connected to neither the analysis channel nor the drainage channel.

A multidimensional chromatographic assembly includes a chromatographic medium selector module, which receives a sample from an injector module and moves the sample through one of at least two chromatographic media of a chromatographic medium module using at least one eluent from at least one fluid moving module. At least a portion of the sample is re-circulated through the same or the second chromatographic medium using a multi-configuration fluid diverting module, which isolates a selected portion of the chromatographed eluent containing at least a portion of the sample in at least one fluid holding compartment and later moves the isolated portion through one of the chromatographic media in an iterative manner until all attributes of the isolated portion in question are analyzed. A detector module, which is located between the chromatographic medium selector module and the fluid diverting module, acquires data each time a portion of the sample passes through the detector module and provides data for a multidimensional chromatogram. The configurable portion (the rotor) of the fluid diverting module comprises movable flow-paths with two termini, which lie on a circular perimeter, concentric to the axis of rotation of the rotor, on the interfacial plane where the rotor meets the stationary portion of the fluid diverting module (the stator), and a connecting coplanar groove, spatial disposition of which is either concave or convex to the circular perimeter with only the termini intercepting the perimeter. The entire assembly is controlled by a controller, which receives data from the detector module and sends instructions to all modules during the multidimensional analysis with or without human intervention.

A target component is collected using a preparative separation and purification device having a holder for holding a trap column in which the target component has been captured, a liquid feeder for feeding a first solvent having compatibility with the water remaining in the trap column and a second solvent having low compatibility with water and high compatibility with the first solvent into the trap column, a flow-path switch for connecting the exit end of the trap column to a waste liquid flow path and a collection flow path, and a control unit for controlling the flow-path switch so that solution including water flows into the waste liquid flow path.

A gas analyzer includes: a column that separates a component in a sample gas; a valve that switches, between a test sample gas and a standard sample gas, the sample gas to be supplied to the column; a valve that adjusts an introduction amount of the sample gas to be supplied to the column; a detector that detects, by gas chromatography, the component in the sample gas separated by the column; and a control device. The control device controls the valve to allow the introduction amount to be a predetermined amount, calculates a peak area value of a chromatogram obtained by the detector when the introduction amount is the predetermined amount, and calculates a correspondence between the introduction amount and the peak area value.

The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.

A liquid analysis device (HPLC device) includes a main flow path provided with a first buffer portion, a first switch valve, an HPLC column, a second switch valve, and a second buffer portion; and a bypass flow path that bypasses the HPLC column. A controller, by controlling a pump, the first switch valve, and the second switch valve, switches between a first path that allows at least a portion of a fluid held in the first buffer portion to flow into the second buffer portion through the main flow path and a second path that allows a fluid held in the second buffer portion to flow into the first buffer portion through the bypass flow path spanning between the first switch valve and the second switch valve in the main flow path.

A monitoring analysis device includes an acquirer that sequentially acquires reaction products produced by a reactor, an analyzer that sequentially analyzes the reaction products acquired by the acquirer, a pre-processor that performs a pre-process to be performed before an analysis of the reaction products by the analyzer, and a controller that controls the pre-processor such that the pre-process for a second analysis to be performed subsequently to a first analysis is performed during the first analysis by the analyzer.

A gas analyzer includes: a column that separates a component in a sample gas; a valve that switches, between a test sample gas and a standard sample gas, the sample gas to be supplied to the column; a valve that adjusts an introduction amount of the sample gas to be supplied to the column; a detector that detects, by gas chromatography, the component in the sample gas separated by the column; and a control device. The control device controls the valve to allow the introduction amount to be a predetermined amount, calculates a peak area value of a chromatogram obtained by the detector when the introduction amount is the predetermined amount, and calculates a correspondence between the introduction amount and the peak area value.