A pharmaceutical packaging is provided including a glass, comprising at least the following components (given in mol % on oxide basis): SiO.sub.2:59-84, Al.sub.2O.sub.3:7-18.5, CaO:1-25, SrO:0-6.5, BaO:0-5, ZrO.sub.2:0-3, TiO.sub.2:0-5, B.sub.2O.sub.3:0-1, wherein the ratio (CaO+SrO+BaO)/Al.sub.2O.sub.3<2.8, wherein the ratio (CaO+SrO+BaO)/SiO.sub.2≦0.39, wherein the hydrolytic resistance according to DIN ISO 720 is class HGA 1, and wherein the glass, apart from unavoidable contaminations, is free of alkali oxides and magnesium oxides.

The present invention is directed to methods for filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to methods for detecting headspace in a container.

A strengthened glass container or vessel such as, but not limited to, vials for holding pharmaceutical products or vaccines in a hermetic and/or sterile state. The strengthened glass container undergoes a strengthening process that produces compression at the surface and tension within the container wall. The strengthening process is designed such that the tension within the wall is great enough to ensure catastrophic failure of the container, thus rendering the product unusable, should sterility be compromised by a through-wall crack. The tension is greater than a threshold central tension, above which catastrophic failure of the container is guaranteed, thus eliminating any potential for violation of pharmaceutical integrity.

A container assembly with improved mixing dynamics for mixing substances in preparation for injection by an injection device or for the dispersion of additives in the collection and analysis of biological samples is disclosed. In one configuration, the container assembly includes a first mixing element protruding into an interior of a container. With the container rotated about its longitudinal axis, the first mixing element forms at least one vortex which effectuates mixing of a first substance provided within the container interior and a second substance provided within the container interior.

An adapter assembly for establishing bidirectional fluid connection between a cartridge and a vial includes a housing having an open first end adapted to engage the cartridge and a second open end adapted to engage the vial. The adapter includes a needle assembly having a first tip and a second tip, with the needle assembly disposed within the housing and at least partially supported by a needle holder. The needle assembly is movable relative to the housing from an initial position in which the first and second tip are isolated from the cartridge and vial, to an end of use position, in which first tip is engaged with the vial and the second tip is engaged with the cartridge, establishing fluid communication therebetween. The needle assembly is maintained in the initial position by a locking structure which is released by rotationally advancing the needle holder relative to the housing.

A system is disclosed for inserting a pharmaceutical cartridge into a delivery device. Optionally the cartridge is inserted in an arbitrary orientation. Optionally, the system reorients the cartridge to a locked orientation. For example, a driver applies a torque to the cartridge to cause the reorienting. For example, said torque rotates the cartridge around an axis thereof until the cartridge reaches the locked orientation. Optionally, when the cartridge reaches the locked orientation an interference element on the cartridge interlocks with a complementary interference element on the delivery device to lock the cartridge in the locked orientation. Optionally when the cartridge is locked in the second orientation, the torque causes discharge the pharmaceutical.

Systems, devices, and methods are disclosed for pen that distributes viscous plant material, such as rosin, from a cartridge. The pen receives, from a button, input corresponding to a first control instruction. The pen has a motor configured to receive the first control instruction from the controller and, in response, drive a spindle that linearly displaces a plunger, wherein the linear displacement of the plunger causes plant material to be pushed out of a nozzle of the pen. The pen cartridge includes a rubber plug configured to be linearly displaced by the plunger to cause rosin to be disturbed from the cartridge.

A method of reducing static charge of a plastic container is provided. The method includes providing a PECVD coating of SiCOH, SiO.sub.x or SiOH to an external support surface of the container. The PECVD coating reduces static charge of the container compared to a reference container that is essentially identical to the container except that the reference container is uncoated.

A strengthened glass container or vessel such as, but not limited to, vials for holding pharmaceutical products or vaccines in a hermetic and/or sterile state. The strengthened glass container undergoes a strengthening process that produces compression at the surface and tension within the container wall. The strengthening process is designed such that the tension within the wall is great enough to ensure catastrophic failure of the container, thus rendering the product unusable, should sterility be compromised by a through-wall crack. The tension is greater than a threshold central tension, above which catastrophic failure of the container is guaranteed, thus eliminating any potential for violation of pharmaceutical integrity.

An injector including: a housing having an exterior wall, with pairs of slots formed therein, each pair of slots being diametrically opposed to each other; a needle hub having an exterior wall and an interior wall extending interiorly across the exterior wall, forming upper and lower compartments; a first needle extending upwardly from the interior wall, into the upper compartment, a second needle extending downwardly from the interior wall into the lower compartment, the interior wall having an opening forming a fluid passageway; a first cartridge and a second cartridge, each having a plunger and a pierceable cap; a base member having a base bottom wall with a plunger wall extending upwardly therefrom. The first cartridge is inserted into the base member such that the plunger seats on the plunger rod, and the second cartridge is in the housing with the pierceable cap of the second cartridge facing the first needle.