Liquid dispenser for discharging pharmaceutical liquid having a discharge head and a cap, the cap body of which has a ventilation opening. The dispenser includes an injection-moulded pull-off portion which, in the delivery state, covers the ventilation opening and is connected to the cap body by a substance-to-substance bond. The pull-off portion, together with a tamper-evident portion, which, with the dispenser in the delivery state, prevents removal of the cap body, is part of a common segment which is detachable from the cap body of the cap. Alternatively, the ventilation opening is provided with a filter membrane for filtering the air which flows through it, and the cap body includes two part-bodies which together form a receiving space for the filter membrane.

A protective cap for a dispenser for discharging pharmaceutical and/or cosmetic liquids. The dispenser has a liquid reservoir and a discharge opening through which the liquid can be dispensed into a surrounding atmosphere. The protective cap has at least one ventilation opening for establishing communication between an interior and an outer surrounding area, and a sterile filter which covers the at least one ventilation opening is arranged on the protective cap in order to reduce or prevent an introduction of microbes into the interior of the protective cap via the at least one ventilation opening.

The invention relates to a device for dispensing an aqueous liquid through an interface membrane made partially hydrophilic and partially hydrophobic, made so that when in operation, during each operation of dispensing a metered amount of liquid, the streams of air and liquid flow alternately in a capillary channel (18) downstream from the membrane. Said interface membrane (7) is made of a filtering material which includes biocidal metal cations in the body thereof. Said device comprises a porous insert (8), which is permeable both to liquid and to air, which is arranged upstream from the membrane in the path of the fluids and which is made of a material including sites with negative charges capable of attracting biocidal metal cations from said membrane.

Drug delivery devices, sealing members for containers housed within such drug delivery devices, and related methods of assembly are disclosed. The drug delivery device may include a housing, a container disposed in the housing and having an interior volume, a drug disposed in the interior volume, and a septum. The container may have an opening formed in an end surface and which communicates with the interior volume. The septum may include a proximal end inserted through the opening into the interior volume of the container. Additionally, the septum may include a distal end having a flange disposed outwardly of the proximal end and contacting the end surface of the container. At least an end portion of the flange may be made of a material that is permeable to a gaseous sterilizing agent.

The container (1), particularly for medical products, pharmaceuticals, cosmetics, food or the like, comprises: an hollow body (2) at least partly compressible defining a chamber (3) for containing a fluid product (4) and provided with a neck (5); a closure element (6) made in a single body piece with the hollow body (2) and provided with an attachment portion (7) which, in a packaging configuration, is associated with the hollow body (2) along a predefined breaking line (8) adapted to allow the separation of the closure element (6) from the hollow body (2) in a configuration of separation in which on the hollow body (2) is formed a dispensing opening (9) of the fluid product (4); a dispensing valve (13) adapted to allow the outflow of the fluid product (4) through the dispensing opening (9); and a return valve (14) adapted to allow the one-way flow of air (15) towards the chamber (3), wherein the return valve (14) comprises filtering means (16) adapted to filter the air (15) entering the chamber (3).

The invention proposes a biological protection membrane which is mounted, in a device for dispensing liquid from a sterile packaging bottle, across a fluid-circulation duct, in the path of the liquid extracted from the bottle and the outside air which is drawn into the bottle. The membrane (7) is made partially of a hydrophilic material and partially of a hydrophobic material. Both the hydrophobic portion (23) and the hydrophilic portion (22) are made from a polymer base, laden in the body thereof with a biocidal agent that is active in the destruction of bacteria by the ionic oxidation effect. The circulation of fluids through the membrane (7) is organised so as to promote the ionic action on the flow of outside air in the hydrophobic material, and to drive the ionically charged active agent by the liquid passing through the membrane in the hydrophilic portion thereof. A porous buffer (8), inserted in the path of the fluids on the inside of the membrane, collects the active agent extracted from the membrane by the remaining liquid not dispensed, passing through the membrane from the outside towards the inside.

A system for storing pharmaceuticals or biological media comprising a bag including a flexible sidewall defining an opening; and a vent coupled with the flexible sidewall at the opening and defining a vent passageway between an internal volume of the bag and an external environment, wherein the vent is coupled with the bag at a location spaced apart from and above the opening.

Liquid dispenser for discharging pharmaceutical liquid having a discharge head and a cap, the cap body of which has a ventilation opening. The dispenser includes an injection-moulded pull-off portion which, in the delivery state, covers the ventilation opening and is connected to the cap body by a substance-to-substance bond. The pull-off portion, together with a tamper-evident portion, which, with the dispenser in the delivery state, prevents removal of the cap body, is part of a common segment which is detachable from the cap body of the cap. Alternatively, the ventilation opening is provided with a filter membrane for filtering the air which flows through it, and the cap body includes two part-bodies which together form a receiving space for the filter membrane.

Liquid dispenser for discharging pharmaceutical liquid having a discharge head and a cap, the cap body of which has a ventilation opening. The dispenser includes an injection-moulded pull-off portion which, in the delivery state, covers the ventilation opening and is connected to the cap body by a substance-to-substance bond. The pull-off portion, together with a tamper-evident portion, which, with the dispenser in the delivery state, prevents removal of the cap body, is part of a common segment which is detachable from the cap body of the cap. Alternatively, the ventilation opening is provided with a filter membrane for filtering the air which flows through it, and the cap body includes two part-bodies which together form a receiving space for the filter membrane.

A package for administration of fluid medicinal or nutritional substances features an outer bag with a sterile or sterilized inner chamber and inside chamber a bottle of medicinal or nutritional substance with a neck, a pierceable cap and a device for the withdrawal and/or reconstitution of the substance, placed below the cap of the bottle. The device comprises a perforation needle axially movable to the bottle and an outflow tube extending out of the bag equipped with an openable closure. The perforation needle is crossed longitudinally by a first channel connecting with the closure set open to the outflow tube, and a second channel with a side opening equipped with a hydrophobic filter configured to allow, after perforation of the cap, only air or other gaseous fluids to flow from inside the bottle into the inner chamber of the bag or vice versa.