Enhanced stability for aztreonam is achieved by separate packaging of aztreonam and a physiologically acceptable liquid carrier therefor prior to constitution of an aztreonam solution suitable for administration by injection or inhalation. A manually activatable package having a chamber preferably containing anhydrous β-aztreonam powder and a separate chamber in the same package containing a solvent for the β-aztreonam powder for convenient constitution of β-aztreonam prior to administration is described.

A pre-filled medical delivery system can have a blow-fill-seal (BFS) module and a mixing assembly. The BFS module can have first and second chambers, first and second sealed ports, and first and second actuation members. Each chamber can have a respective liquid agent therein. Each sealed port and each actuation member can be in fluid communication with a respective one of the chambers. The mixing assembly can be constructed for coupling to the BFS module. When coupled to the BFS module, the mixing assembly can breach the seals of the first and second ports and provide fluid communication therebetween. The disclosed systems, when assembled, can combine the liquid agents from the first and second chambers of the BFS component and deliver the combination as a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) to a patient.

A multi-mix infusion bag is provided. The multi-mix infusion bag includes a lower portion and an upper portion. The lower portion has a lower chamber and the upper portion includes a plurality of chambers. Each chamber is separated and contains a fluid agent. The multi-mix infusion bag is configured to transfer each fluid agent within each chamber of the upper portion into the lower chamber for mixing. The multi-mix infusion bag may include dispensing devices associated with each chamber, wherein the dispensing devices operate to transfer the fluid agents into the lower chamber for mixing.

A mixing vial having a hollow interior chamber with a tubular portion having distal and proximal open ends and a stopper positioned in sealing relationship in the tubular portion, the stopper having a hollow interior chamber with an open end and a dislodgeable plug positioned in and sealing the open end.

The present invention of the system discloses a clear glass or plastic cylinder filled with small frosted glass beads. The cylinder is connected to two syringes by luer locks. The syringes force the blood sample through the cylinder running the sample over the frosted beads. The process includes rupturing of blood platelets based on contact between the surface area of the frosted glass rod and the blood, reducing processing time is as simple as increasing surface contact and increasing shear mixing.

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

A lyophilisate container (39) comprising a compartment; a wall (3119, 3129) limiting the compartment; and a lyophilisate arranged inside the compartment. At least a portion of the wall (3119, 3129) is semipermeable allowing vapour permeation in one direction out of the compartment through the wall (3119, 3129) and preventing vapour permeation in an opposite direction into the compartment through the wall (3119, 3129).

A method of manufacturing a flexible container (1) housing a drug substance, comprises: forming a first compartment (11) of the container (1) out of a flexible sheet-like material, filling a liquid (2) into the first compartment (11) of the container (1), sealing the first compartment (11), forming a second compartment (12) of the container (1) out of the flexible sheet-like material, filling a dry drug formulation (3) into the second compartment (12), and sealing the second compartment (12). The method further involves lyophilizing the drug formulation inside a tubular cartridge such that the dry drug formulation (3) is generated and held in the tubular cartridge, wherein filling the dry drug formulation (3) into the second compartment (12) comprises: introducing the tubular cartridge holding the dry drug formulation (3) through an opening of the second compartment (12) of the container (1) such that an open end of the tubular cartridge is positioned distant from the opening of the second compartment (12), providing the dry drug formulation (3) out of the open end of the tubular cartridge into the second compartment (12), and withdrawing the tubular cartridge out of the opening of the second compartment (12) of the container (1). The first compartment (11) is separated from the second compartment (12) by a frangible seal (14) which opens when the first compartment (11) is compressed.

A reagent preparation device (also called sterile and safe reagent preparation device) is disclosed for preparing a solution of a reagent, particularly a toxic chemical. The sterile and safe reagent preparation device comprises a liquid storage for storing a liquid (solvent or other fluid reactant); and a reagent (chemical or other reactant) container for containing a reagent. The liquid storage and the reagent container are configured to be detachably engaged. A method of making the sterile and safe reagent preparation device and a method of using the sterile and safe reagent preparation device are also disclosed in the present application.

The invention relates to a body (4) intended for being mounted to/on an outlet of a container with a fluid, adapted for receiving a container (1) for administering a solid medicinal product or a dietary supplement together with a fluid. The invention further relates to the container (1) for administering a solid medicinal product or a dietary supplement together with a fluid, intended for being placed, at least partly, in the body (4) intended for being mounted to a container with a fluid. The invention further relates to a device for administering a solid medicinal product or a dietary supplement together with a fluid, comprising the body (4) for receiving the container (1), intended for being mounted on a container with a fluid, and the container (1) for administering a solid medicinal product or a dietary supplement together with a fluid.