In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

Drug delivery devices, sealing members for containers housed within such drug delivery devices, and related methods of assembly are disclosed. The drug delivery device may include a housing, a container disposed in the housing and having an interior volume, a drug disposed in the interior volume, and a septum. The container may have an opening formed in an end surface and which communicates with the interior volume. The septum may include a proximal end inserted through the opening into the interior volume of the container. Additionally, the septum may include a distal end having a flange disposed outwardly of the proximal end and contacting the end surface of the container. At least an end portion of the flange may be made of a material that is permeable to a gaseous sterilizing agent.

A dispenser comprises a cylinder in fluid communication with a one-way valve and an inlet in fluid communication with the cylinder. A lumen and a flow control member deliver fluid from a container to the inlet. A piston draws fluid through the flow control member and inlet into the cylinder upon movement of the piston in a first direction, and expels the fluid through the one-way valve upon movement of the piston in a second direction. The dispenser may be activated by either a “dual-action” mode of operation where an activating member is moved to retract the piston and provide the stored energy and then an-actuator is depressed to release the stored energy to the piston or a “single-action” mode of operation where an actuator is depressed in a single direction which concurrently retracts the piston, provides the stored energy and then releases the stored energy to piston.

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constintuent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

Provided is a pressure equalizing device for facilitating drug reconstitution in a closed system. The pressure equalizing device includes a container for attachment to a receptacle, to permit pressure equalization between the container and the receptacle. The container includes a first chamber and a second chamber. The device further includes a vent channel extending between the first chamber and a distal opening of the vent channel. In accordance with the invention, when the receptacle is connected to the pressure equalizing device, the vent channel establishes direct fluid communication between the first chamber and the receptacle. Additionally, a longitudinal axis of the pressure equalizing device is configured to be aligned with or parallel to a longitudinal axis of the receptacle when the pressure equalizing device is attached to the receptacle.

A fluidic group (21) couplable to a first container (24) adapted to contain a drug and a second container (22) adapted to contain an ingredient, comprising: a syringe (154) comprising a movable piston (150) defining a chamber (162a) having a variable volume; a first (171, 172) and a second (25) coupling group selectively fixable to the second (22) and, respectively, to the first (24) container; a forking element (166) having a first (166′), a second (166″) and a third (166′″) inlet in fluid communication with each other and, respectively, with the first coupling group (171, 172), with the second coupling group (25) and with the chamber (162a); a first one-way valve (168) interposed between the first coupling group (171, 172) and the forking element (166) and controllable to allow the passage of the ingredient from the second container (22) to the chamber (162a); and a second one-way valve (176) interposed between the second coupling group (25) and the forking element (166) and controllable to allow the passage of the ingredient from the chamber (162a) to the first container (24).

An insulin storage and dispensing system for housing a standard insulin bottle and securely keeping the bottle in place when using a syringe to access the port on the top of the bottle to fill the syringe while providing accessibility in the form of a convenient mounting assembly for mounting on a refrigerator, an interior cabinet door or wall.

Liquid drug transfer devices with universal drug vial adapters for use with a drug vial of a small drug vial and a large drug vial. Some universal drug vial adapters employ the same generally opposite upright flex members for clamping a small drug vial and a large drug vial. Other universal drug vial adapters include a set of minor flex members for clamping a small drug vial and a set of major flex members encircling the set of minor flex members for clamping a large drug vial whereupon the large drug vial underlies the set of minor flex members. Liquid drug transfer devices with a universal injection port connector for attachment on an injection port of an infusion bag.

A fill adapter for filling a reservoir and a related method are disclosed herein. The fill adapter includes a button assembly actuator and a pump chamber plunger actuator hingably attached to the button assembly actuator, wherein the actuation of the button assembly actuator actuates the pump chamber plunger actuator and wherein the pump chamber plunger actuator actuates a pump chamber membrane before the at least one button assembly is actuated.

A vial for storing multiple doses of a substance to be dispensed into one or more syringes or other delivery devices. The vial has a body, a variable-volume storage chamber within the body for storing multiple doses of the substance therein, and a one-way valve connectable in fluid communication with a syringe or other delivery device. The one-way valve is moveable relative to the body between first and second positions (i) one of which permits the valve to open so that substance from the variable-volume storage chamber can flow therethrough and into the syringe or other delivery device connected in fluid communication therewith, and (ii) one of which prevents the valve from opening.