A cap and seal system for a liquid medicament container. The system comprises a cap formed from a substantially rigid material, and has a retention component integrally formed therewith. A seal is formed from a material which is less hard than the cap and positioned within the cap such that, when the retaining component retains the cap on a container in use the seal is positioned such that it forms a fluid tight seal between the cap and the container. A recess is formed in the seal through which a liquid outlet channel can pass in use to access the contents of the container via the cap and the seal.

A vial adaptor can include a connector interface and/or a piercing member. The vial adaptor can include a regulator assembly. The regulator assembly can include a regulator base, a regulator nest coupled with the regulator base, and/or a storage chamber formed at least partially by one or both of the regulator base and regulator nest. The regulator assembly can include a cover connected to one or both of the regulator base and regulator nest and fitted around a radially outward portion of one or both of the regulator base and regulator nest. In some cases, the regular assembly includes a flexible enclosure connected to the regulator nest and configured to transition between a contracted configuration and an expanded configuration. In some cases, the flexible enclosure is inhibited from transitioning to the expanded configuration prior to removal or modification of the cover from the regulator assembly.

A container adapter for a medical delivery device is disclosed. The medical delivery device has a container seat for holding a container, a dosage chamber, a dosing mechanism and a lock mechanism adapted to prevent operation of the dosing mechanism when no container is held in the container seat and to allow operation of the dosing mechanism when the container is held in the container seat. The container adapter includes an adapter container seat arranged to hold a container, a joint structure arranged to be detachably positioned in the container seat of the medical delivery device and to connect the adapter container seat to the dosing mechanism, and an unlock member adapted to activate the lock mechanism. A delivery assembly and a method of delivering a liquid to a patient from different containers is also disclosed.

A method includes: depositing whole blood into at least one separator tube; subjecting the at least one separator tube to a first centrifugal force to cause a combination of the first centrifugal force and separator gel within each separator tube of the at least one separator tube to separate plasma of the whole blood from red and white blood cells of the whole blood within the at least one separator tube, wherein the plasma includes α2M molecules; transferring one or more portions of the plasma from within the at least one separator tube and into at least one isolator; and subjecting the at least one isolator to a second centrifugal force to cause a combination of the second centrifugal force and a filter within each isolator of the at least one isolator to isolate the α2M molecules from other components of the plasma within the at least one isolator.

A medical device for making foam includes a syringe having a plunger for dispensing a liquid from a liquid dispensing port, and a mixing chamber including a mixing chamber inlet, a mixing chamber outlet, a liquid flow channel extending between the mixing chamber inlet and the mixing chamber outlet, and a gas inlet channel that intersects with the liquid flow channel. The system has a gas cartridge containing the gas, a first gas conduit connected with the syringe, and a second gas conduit connected with the gas inlet channel. An actuator is coupled with the gas cartridge for releasing the gas into the first and second gas conduits. The released gas in the first gas conduit forces the plunger toward the liquid dispensing port for dispensing the liquid from the liquid dispensing port and into the liquid flow channel while the released gas in the second gas conduit flows into the gas inlet channel of the mixing chamber for mixing with the liquid in the liquid flow channel.

The invention provides a drug mixing and injection system, in particular an adapter for said system enabling the preparation of drug formulations. In a first aspect, the invention relates to an adapter for a drug mixing and injection system comprising a first subunit (110) adapted to hold a vial (113) and a reservoir (115) with injectable liquid, a second subunit (120) comprising a valve (115) and an outlet port (122), at least one internal adapter channel (131), a first cannula (134) between the vial (113) and the internal adapter channel (131), wherein the adapter (100) has a resting position and an activated position. In another aspect, the invention relates to a drug mixing and injection system (200) comprising the adapter of the first aspect of the invention, a vial and a reservoir with injectable liquid. In a further aspect, the invention relates to a method of preparing an injectable drug formulation by use of the drug mixing and injection system (200) of the above mentioned aspect of the invention comprising activation of the system and transferring an injectable liquid from the reservoir to the vial, mixing the drug and transfer the resulting injectable drug formulation back to the reservoir, bringing the valve to a second position and transferring the injectable drug formulation to the outlet port.

A device for connecting tubes for a drug delivery system includes a connecting portion having a first tube channel, a second tube channel, a connecting heating element, and a carriage assembly. The first tube channel is adapted to receive a first tube, and the second tube channel is adapted to receive a second tube. The connecting heating element is positioned adjacent to and/or intersecting the first and second tube channels and is adapted to selectively heat at least a portion of the first and second tube. The carriage assembly moves the heated first and second tubes into end-to-end contact with each other to couple the first and second tubes together.

An injection system comprising a syringe barrel; a first sealing element and a second sealing element moveably disposed in the syringe barrel; an injection chamber between them; a puncture element extending from the first sealing element to deliver an injection agent from the injection chamber into a biological space, wherein one or more of the syringe barrel, the first or the second sealing element are configured to prevent proximal movement of the first sealing element past a pre-selected location, while allowing the second sealing element to come in contact with the first sealing element, the system is configured such that, when a force is applied on the second sealing element in a distal direction, in response to a first opposing force, the puncture element advances and in response to a second opposing force, the puncture element remains stationary and the injection agent is conveyed through the puncture element.

An adapter for connection with a fluid container includes an outer housing having a distal end, a proximal end, and a substantially cylindrical sidewall extending between the distal end and the proximal end, an inner member including a body rotatably inserted within the outer housing, a connector extending from the body configured to connect the adapter to a fluid container, and at least one grasping member extending from the inner member, the grasping member being configured for grasping by a user of the adapter, a first locking arrangement engageable with a distal end of the inner member and configured to restrict the inner member from rotating relative to the outer housing in a first direction, and a second locking arrangement engageable with a proximal end of the inner member and configured to restrict the inner member from moving in a proximal direction relative to the outer housing.

Various embodiments are provided herein for checking proper inclusion and sequencing of drug modules in a combinatorial drug delivery device.