A system for polishing capsules includes a brush located at least partially inside a wall arranged around an axis (Z). The brush has bristles arranged around the axis (Z) to form a helical conveying ramp for the capsules. The lengths of the bristles of the brush are distinct and a protrusion is mechanically coupled to the wall to bend at least some of the bristles of the brush when the latter is in rotational movement around the axis (Z).

A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form and at least one liquid fill phase. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. Method and apparatus for manufacturing the multi phase soft gelatin dosage forms are also described. The solid phase, liquid phase or coatings may comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, therapeutic substances, functional excipients or combinations thereof.

A capsule shell contains 40 to 99% by weight of a core-shell polymer and 1 to 60% by weight of a cellulose. The core-shell polymer contains 50 to 90% by weight of a core, containing polymerized units of 65 to 75% by weight of ethyl acrylate and 25 to 35% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 45 to 55% by weight of ethyl acrylate and 45 to 55% by weight of methacrylic acid.

A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form and at least one liquid fill phase. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. Method and apparatus for manufacturing the multi phase soft gelatin dosage forms are also described. The solid phase, liquid phase or coatings may comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, therapeutic substances, functional excipients or combinations thereof.

A method for producing starch soft capsules comprises the following steps: preparing a mixture comprising starch, plasticizer and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C.; and shaping the film to form a soft capsule. Soft capsules produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device to enable shaping of the starch material to form a film, and a heating device to perform a heat treatment to destructure the starch during and/or after the shaping. It comprises a rotary die device.

A long release capsule for extended delivery of a drug to a patient in an ingestible capsule, including systems and method for producing the same are described herein. The long release capsule includes a buoyancy compartment to cause the capsule to float and a drug compartment with openings to release the drug at a predetermined rate. The capsule is either enteric in nature or coated with an enteric coating and floats in gastric fluid for a controllable period of time. At the end of the period of time the coating dissolves and the capsule fragmentizes and sinks within the gastric fluid.

Provided is a gelatin supply device for a softgel encapsulation machine, the device having multiple spreader boxes provided on a guide having adjustment holes arranged in an arc shape to form multiple gelatin sheets, the device being further provided with a printing unit between the provided spreader boxes to print an information mark on an upper surface of a gelatin sheet while forming the gelatin sheet, the device forming a shell of a capsule by covering the information mark with another gelatin sheet.

Various methods and apparatuses are presented for an ingestible capsule that includes a digital, ingestible sensor component—or ingestible sensor—embedded into the capsule. The ingestible sensor component may be configured to activate upon coming into contact with conductive fluid, such as a body's stomach fluid. Once activated, the ingestible sensor component may be configured to perform various tasks, such as transmitting one or more signals and obtaining biometric data about the body that ingested the capsule.

A pullulan empty hard capsule and a preparation method therefor. The empty hard capsule includes the following components: 82-89 wt % of pullulan having a pH of 6-7, 1-1.4 wt % of gelling agent, 0.8-1.4 wt % of coagulant aid, 0.01-0.04 wt % of humectant, 0.01-0.04 wt % of surfactant, and 10-14 wt % of purified water. The preparation method for the pullulan empty hard capsule includes: weighing the components; dissolving the gelling agent, the coagulant aid, the humectant, the surfactant, a light-screening agent, a food coloring with 80-90° C. purified water, putting the dissolved substances into a gel dissolving barrel, stirring till the gelling agent is dissolved, adding the pullulan having a pH of 6-7 while stirring, after the pullulan is completely dissolved, cooling, preparing a capsule by means of a glue dipping method, and drying.

Provided is a device (1) for drying a columnar structure (30) supported upright on a supporting surface (2a), wherein a feeding part (5a) for feeding drying gas toward the supporting surface (2a) and a discharge part (6b) for discharging the fed drying gas are both provided in an opposing surface (6a) facing the supporting surface (2a). A plurality of feeding parts (5a) and a plurality of discharge parts (6b) are preferably provided, and the plurality of discharge parts (6b) are preferably symmetrically disposed around one feeding part (5a).