A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

The present invention discloses a root canal dental paste that has include a first portion made from at least one antibiotic compound and partially set calcium based cement which forms a matrix to at least partially encapsulate the antibiotic compound. The first portion is then ground and combined with a second portion being a non-setting material and an antibiotic to form a paste.

The present invention is directed to a process for producing a sintered lithium disilicate glass ceramic dental restoration out of a porous 3-dim article, the process comprising the step of sintering the porous 3-dim article having the shape of a dental restoration with an outer and inner surface to obtain a sintered lithium disilicate ceramic dental restoration, the sintered lithium disilicate glass ceramic dental restoration comprisingSi oxide calculated as SiO2 from 55 to 80 wt.-%, Li oxide calculated as Li2O from 7 to 16 wt.-%, Al oxide calculated as Al2O3 from 1 to 5 wt.-%, andP oxide calculated as P2O5 from 1 to 5 wt.-%, wt.-% with respect to the weight of the dental restoration, the sintering being done under reduced atmospheric pressure conditions, the reduced atmospheric pressure conditions being applied at a temperature above 600 C. The present invention is also directed to a kit of parts comprising a porous 3-dim article having the shape of a dental milling block and a respective instruction of use.

The present invention relates to: composition for differentiating non-dental mesenchymal stem cells into odontoblasts comprising CPNE7 protein or gene; method for differentiating in vitro non-dental mesenchymal stem cells using the same; and also use thereof.

The present invention is directed to a process for producing a sintered lithium disilicate glass ceramic dental restoration out of a porous 3-dim article, the process comprising the step of sintering the porous 3-dim article having the shape of a dental restoration with an outer and inner surface to obtain a sintered lithium disilicate ceramic dental restoration, the sintered lithium disilicate glass ceramic dental restoration comprising Si oxide calculated as SiO2 from 55 to 80 wt.-%, Li oxide calculated as Li2O from 7 to 16 wt.-%, Al oxide calculated as Al2O3 from 1 to 5 wt.-%, and P oxide calculated as P2O5 from 1 to 5 wt.-%, wt.-% with respect to the weight of the dental restoration, the sintering being done under reduced atmospheric pressure conditions, the reduced atmospheric pressure conditions being applied at a temperature above 600 C.

The present invention is also directed to a kit of parts comprising a porous 3-dim article having the shape of a dental milling block and a respective instruction of use.

Provided is a dental glass ionomer cement composition whose hardened cement has a high strength, despite not including a (meth)acrylate monomer. The dental glass ionomer cement composition includes a filler in which a compound(s) having a carboxyl group(s) is/are bound to a surface of an inorganic powder via a silicon atom, the composition not including a (meth)acrylate monomer.

Provided is a curable composition that is for dentistry and that contains: a polymerizable monomer (A); an inorganic filler (B) having an average particle size of 0.1-1 m; an organic-inorganic composite filler (C) having an aggregate structure in which inorganic primary particles having an average particle size of 10-1000 nm are bonded together through a resin layer covering the surface of the particles, to form a void having a specific pore volume; and a polymerization initiator (D). In the organic-inorganic composite filler (C), a curved surface-shaped organic-inorganic composite filler (C1) formed of organic-inorganic composite aggregate particles having a curved surface shape, and an amorphous organic-inorganic composite filler (C2) formed of amorphous organic-inorganic composite aggregate particles having an edge portion, are mixed such that C1/(C1+C2) equals 0.2-0.8 in terms of the number of particles having a particle size of 5 m or more.

Provided is a curable composition that is for dentistry and that contains: a polymerizable monomer (A); an inorganic filler (B) having an average particle size of 0.1-1 m; an organic-inorganic composite filler (C) having an aggregate structure in which inorganic primary particles having an average particle size of 10-1000 nm are bonded together through a resin layer covering the surface of the particles, to form a void having a specific pore volume; and a polymerization initiator (D). In the organic-inorganic composite filler (C), a curved surface-shaped organic-inorganic composite filler (C1) formed of organic-inorganic composite aggregate particles having a curved surface shape, and an amorphous organic-inorganic composite filler (C2) formed of amorphous organic-inorganic composite aggregate particles having an edge portion, are mixed such that C1/(C1+C2) equals 0.2-0.8 in terms of the number of particles having a particle size of 5 m or more.

Delivery and/or injection systems, preferably for medical applications. Especially, a kit of parts for providing a dental composition able to self-hardening. The kit of parts includes a first waterproof container including an anhydrous calcium silicate phase; and a second container including an aqueous phase. The kit of parts may be used in delivery and/or injection systems so that it delivers a homogenous calcium silicate-based composition having a volume ratio between the calcium silicate phase and the aqueous phase ranging from 1 to 3. Also, the hardened material obtained from the kits of parts, the delivery and/or injection system.