Pharmaceutical formulations to prevent or treat hemorrhagic shock are provided. The pharmaceutical formulations comprise an oxygenation complement comprising a hemoglobin-based oxygen carried (HBOC) and blood plasma. Related methods to prepare the pharmaceutical preparations are also provided. Furthermore, methods to prevent or treat hemorrhagic shock are provided.

Provided herein is a composition of matter comprising dried blood plasma substantially free of blood cell components; and a) a resuscitative mixture comprising at least one saccharide, at least one salt, and at least one high molecular weight, non-ionic, hydrophilic polymer, b) platelets or platelet-derived material, or c) both a) and b).

The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method. The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient. The present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above.

Disclosed are oxygen-containing particles, a manufacturing method therefor, and a use thereof. The oxygen-containing particles comprise a carrier that is safe for the human body and has a large number of micropores or pores distributed on the surface. The oxygen-containing particles further comprise a peroxide crystal attached to the surface of the micropores or pores of the carrier. The oxygen-containing particles in the present invention have the advantage of having microparticles in addition to a slow and controllable release of oxygen. The oxygen-containing particles can achieve local or systemic oxygen supply during embolization, implantation, perfusion and other operations. Furthermore, the oxygen-containing particles can also be used alone to supply oxygen for patients with pulmonary dysfunction.

The disclosure pertains to methods of treating pain. In certain embodiments, the methods comprise administering to a subject a Plasma Protein Fraction (PPF) in an amount that is effective to treat pain.

A composition including a plant medium and a poly-oxygenated metal hydroxide that comprises a clathrate containing oxygen gas molecules. The poly-oxygenated metal hydroxide may comprise of a poly-oxygenated aluminum hydroxide. The composition may include one or more nutrients. The composition may be in a solid form, a fluid form, or a combination thereof. The poly-oxygenated aluminum hydroxide is soluble in a fluid. In one embodiment, the poly-oxygenated metal hydroxide composition may have particles having a diameter of 212 μm or less, and which may be homogeneous.

Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing aging-related conditions such as cognitive disorders. The methods relate to a regimen of pulsed dosing of blood plasma or blood plasma fractions.

The present application discloses a microbubble dispersion system stabilized with polydopamine nanoparticles for highly-efficient intravenous oxygen supply and a method for preparing the same. The method includes: dissolving dopamine, chitosan quaternary ammonium salt and amino-rich polymer in water, adjusting the pH to be alkaline, and then introducing oxygen into the solution; under the strong shear force of a homogenizer, oxygen oxidizing dopamine, and the obtained polydopamine nanoparticles adhering to the interface of oxygen microbubbles during polymerization, forming a compact shell layer of polydopamine particles; finally, adding glutaraldehyde to solidify the shell layer of polydopamine particles adhered to the interface of microbubbles, and obtaining oxygen microbubbles stably dispersed in water by filtration, washing and redispersion. The oxygen microbubbles stabilized with polydopamine nanoparticles have excellent biocompatibility, can realize rapid and efficient delivery of oxygen, and thus have an important application value in the field of highly-efficient intravenous oxygen supply.

The disclosure pertains to methods of improving wound healing. In certain embodiments, the methods comprise administering to a subject a Plasma Protein Fraction (PPF) in an amount that is effective to treat a wound.

The invention relates to an isotonic crystalloid aqueous solution of the type containing Na.sup.+, K.sup.+ and Cl.sup.−, and to the use thereof as a vasodilator.