Provided is a composition and method for delivery of bioactive agents to a cell or a subject. The composition includes nucleic acids derived from plants and the bioactive agents, and the nucleic acids are crossed linked by a cross-linking agent. Such composition is non-toxic, biocompatible and target specific. A method of making the composition is also provided.

The present invention relates to the field of medicine, specifically to the field of treatment of a malignant condition associated with infection with a bacterium that aggravates and/or induces proliferation of the malignant conditions.

Methods and apparatus are described for the partitioning of difficult to handle materials such as viscous and sticky materials. The partitioning is accomplished accurately and precisely using an apparatus to extrude the material in portions on or in receptacles disposed on a stage.

Traditional methods of hash production are very labor intensive, and the skills of the individual play a key role in defining the quality of the finished product. Hash production requires multiple steps and lacks automation, and thus, it is not easily scaled and very costly for commercial production. The present disclosure relates to hashish product comprising a cohesive mass of isolated cannabis trichomes and having substantially uniform characteristics and to a process of making same. The process comprises providing isolated cannabis trichomes; mixing the isolated cannabis trichomes under conditions sufficient to obtain a substantially homogeneous resinous mixture; and retrieving at least a portion of the mixture through an extrusion die to obtain the hash product.

Disclosed are various embodiments of lipid multiparticulate compositions comprising at least one active agent, a low flow point excipient, and a high flow point excipient.

The present disclosure relates to a composition comprising a complex that includes a curcuminoid-based compound and a steviol glycoside, or a curcuminoid-based compound and a licorice extract or a fraction thereof; and a use of the composition for enhancement of immunity according to an enhancement of activity or a cell number of immune cells and/or a use of the composition for prevention, improvement, or treatment of COVID-19.

The complex including curcumin and a steviol glycoside, or a licorice extract or a fraction thereof according to the present disclosure, which are food materials that have been registered with the Ministry of Food and Drug Safety and have received the Generally Recognized as Safe (GRAS) rating from the U.S. FDA, and whose safety has already been confirmed, inhibits symptoms of COVID-19 by activating Th1 cells, CD8 T cells, and NK cells. Therefore, the complex can be provided as a food and pharmaceutical composition for preventing, improving, or treating COVID-19.

A solvent-free method to extract THCA from cannabis, said method comprising: providing a source of THCA-containing cannabis plant; providing a source of natural oil; combining said source of THCA-containing cannabis and said source of natural oil into a blend; milling said blend; optionally, heating the blend during the milling; and extracting a THCA-containing liquid generated during the milling.

An organic acid salt of nicotinamide riboside (NR) is provided, where an organic acid is selected from the group consisting of malic acid, citric acid, royal jelly acid, and the like, and a molar ratio of the NR to the organic acid is 1:2 or 1:1. A compound composition of an organic acid salt of NR and a carrier is further provided, where the carrier is selected from the group consisting of niacin, glutamic acid, royal jelly acid, nervonic acid, microcrystalline cellulose (MCC), and apple cider vinegar powder. The present disclosure adopts an organic acid with strong acidity, and such an organic acid can form an intimate ion pair with NR and show some hydrophobicity, which improves the stability of NR. The carrier can prevent moisture penetration and improve the water resistance of the organic acid salt.

Provided in some embodiments are titration packages, kits, and methods of treating pulmonary arterial hypertension comprising prescribing and/or administering to a patient in need thereof 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof, via a titration scheme that comprises the up-titration of Compound 1, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, over a period of no more than about nine weeks until an optimized dose is administered.

A metabolic enhancing pharmaceutical composition can include xanthohumol and curcumin, and these components can be in extract form, for example. In another example, a method of enhancing the metabolic stability of a curcumin extract in the body can include combining a curcumin extract with an extract of xanthohumol from hops.