The present invention is a thin film patch to be attached to the skin and used for skin treatment or skin care. In particular, a water-soluble polymer compound is formed by means of melt spinning, melt blowing or electrospinning, into a water-soluble non-woven fabric of which the average diameter of fiber is 5 μm or less. The water-soluble non-woven fabric is coated with a coating agent comprising an active ingredient with a skin treatment or skin care effect; therefore, a thin film having the total thickness of 50 μm and the basis weight of 20 gsm or less is formed, wherein the water-soluble non-woven fabric has an electrically conductive material deposited thereon to have electrical conductivity and is connected to an electrode so that a current can be applied thereto.

Unit dosage forms, devices, and kits for topical delivery of topical immunosensitizers are provided. These include dermal patches, glass swabs, and kits containing a dermal patch and a glass swab. Among other advantages, the unit dosage forms, devices, and kits presented herein deliver a more consistent and controlled volume of drug solution, prevent underdosing and overdosing, prevent or discourage repeat dosing, and provide a more consistent skin area to which the drug solution is applied.

Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

A method for creating a consolidated compound for delivering an immunomodulatory and imiquimod to a patient, comprising diluting immunomodulator extract to a desired dilution by transferring a desired quantity of the concentrated immunomodulator to an associated sterile container, the associated sterile container having a defined volume of diluted immunomodulator after dilution thereof, providing a viscous encapsulation material, selecting a prescribed amount of concentrated immunomodulator, the prescribed amount defined as that amount of the diluted immunomodulator extract required to provide a number of doses equal to the number of dispensable increments from the container containing the viscous encapsulation material, introducing the selected amount of each of the diluted immunomodulator extract into the viscous encapsulation material, introducing an amount of imiquimod into the viscous encapsulation material, and mixing the introduced amount of each of the diluted immunomodulator extracts and the introduced amount of imiquimod with the viscous encapsulating material.

The present invention relates to a cutaneous device (2) for the storage and release of molecules, in particular therapeutic molecules, comprising: —a support (6), —a matrix (8) configured to store and release the molecules as a function of the temperature, and —an electro-resistive layer, disposed between the support and the matrix, intended to be subjected to a voltage and comprising at least one thin microporous and/or nanoporous metal layer. The present invention also relates to a transcutaneous delivery device and the corresponding methods of manufacture and use.

An exemplary nasal inhaler band is fitted on the upper lip below the nasal openings of a user. The device provides minimal restriction of ambient airflow into the nostrils during inhalation, while also providing a flow of beneficial vapors into such airflow. A main body of the device has an outer layer adapted to hold vapor-releasing solids, liquids or gels. The outer layer is air-permeable and absorbent. The main body also has a base layer contacting the upper lip. The base layer is impermeable, so that volatile solids, liquids or gels do not come into contact with the user's skin. The main body is held in position in contact with the nose and upper lip by elastic straps extending back from ends of the main body to wrap around the user's ears.

Provided is a patch including at least one pressure-absorbing member, the pressure absorbing member formed of a resilient material and having at least a first surface, the at least first surface is configured with a plurality of projections extending therefrom and a plurality of channels crossing one another at a plurality of intersections, an outermost surface of said plurality of projections lies along a projections plane of the pressure-absorbing member, the projections being deformable when subjected to pressure applied to the patch, so as to absorb at least some of the applied pressure.

A transfer sheet including a thin-film layer having an average mass of 0.01 g/m.sup.2-10 g/m.sup.2, and a support layer having a support surface in contact with the thin-film layer and including fibers on the support surface. The thin-film layer includes contact portions in contact with the fibers and a non-contact portion separated from the fibers, the contact portions include at least one portion in contact with at least one of the fibers such that the at least one portion extends along a surface of the at least one fiber in contact therewith, and the thin-film layer has an average film thickness in the at least one portion which is less than an average film thickness of the thin-film layer in the non-contact portion.

Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween. The impregnating liquid fills spaces between said solid features, the surface stably contains the impregnating liquid between the solid features, and the impregnating liquid is substantially held in place between the plurality of solid features regardless of orientation of the surface.