The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency.

The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency.

Embodiments of the present invention provide improved livestock foot bath solutions that are capable of maintaining a low pH during longer periods of use in order to help prevent the metal salts from precipitating out of the solution and rendering the solution ineffective. Embodiments of the present invention provide improved livestock foot bath solutions that include one or more weak organic acids, such as polyprotic organic acids, in the aqueous solution, along with the dissolved metal salts. Embodiments of the invention may also include sulfuric acid, or some other strong acid, together with citric acid and the dissolved metal salts in the aqueous solution.

Embodiments of the present invention provide improved livestock foot bath solutions that are capable of maintaining a low pH during longer periods of use in order to help prevent the metal salts from precipitating out of the solution and rendering the solution ineffective. Embodiments of the present invention provide improved livestock foot bath solutions that include one or more weak organic acids, such as polyprotic organic acids, in the aqueous solution, along with the dissolved metal salts. Embodiments of the invention may also include sulfuric acid, or some other strong acid, together with citric acid and the dissolved metal salts in the aqueous solution.

Disclosed herein are methods for (a) inhibiting, reducing, slowing, or preventing, the aging of a subject, (b) for treating, inhibiting, reducing, or preventing an age-related disease in the subject, and/or (c) for increasing the lifespan of the subject which comprise administering to the subject one or more glutarate compounds, such as α-ketoglutate, and/or one or more glutamate compounds, such as 2-hydroxypentanedioate, and compositions thereof.

Disclosed herein are methods for (a) inhibiting, reducing, slowing, or preventing, the aging of a subject, (b) for treating, inhibiting, reducing, or preventing an age-related disease in the subject, and/or (c) for increasing the lifespan of the subject which comprise administering to the subject one or more glutarate compounds, such as α-ketoglutate, and/or one or more glutamate compounds, such as 2-hydroxypentanedioate, and compositions thereof.

The present disclosure provides a protein beverage composition for a sports drink that refreshing and hydrating whilst also providing the nutrients required to assist with muscle recovery and growth after exercise in the form of a whey protein isolate, as well as containing a nutrient mix specifically designed to combat the adverse effects of alcohol consumption on recovery. The nutrient mix contains iron in a from such as ferrous citrate, biotin vitamin B7, and a mix of electrolytes for keeping the drinker hydrated and nourished when used as a mixer or chaser for an alcoholic beverage. The composition can be provided in any number of flavours.

The present disclosure provides a protein beverage composition for a sports drink that refreshing and hydrating whilst also providing the nutrients required to assist with muscle recovery and growth after exercise in the form of a whey protein isolate, as well as containing a nutrient mix specifically designed to combat the adverse effects of alcohol consumption on recovery. The nutrient mix contains iron in a from such as ferrous citrate, biotin vitamin B7, and a mix of electrolytes for keeping the drinker hydrated and nourished when used as a mixer or chaser for an alcoholic beverage. The composition can be provided in any number of flavours.

The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

The present disclosure provides a nutritional formula comprising alpha-lactalbumin enriched whey protein concentrate; beta-casein enriched milk protein; mildly hydrolyzed milk protein; osteopontin; lactoferrin; oleic acid-palmitic acid-oleic acid triglyceride, wherein palmitic acid is at the SN-2 position of the glycerol backbone of the triglyceride; lactose, wherein the lactose is reduced lactose; lutein; docosahexanoic acid; arachidonic acid; galactooligosaccharides; and polydextrose. The provided nutritional formulas may be useful in providing nutrition and/or promoting postnatal development of a subject (e.g., promoting postnatal development of an infant's gastrointestinal functions, nutrient absorption, immune system development, etc.). Also provided are powder forms, reconstituted formulas, kits, methods, and uses that include or involve a nutritional formula described herein.